GlyCosmos Portal

GlyCosmos Diseases

List of diseases involving glycan related genes. The information of each database of Glyco-Disease Genes Database (GDGDB), DisGeNET, and Alliance of Genome Resources is integrated into one list.

Database	Last Updated
Alliance of Genome Resources	February 28, 2024
DisGeNET	February 14, 2024
Glyco-Disease Genes Database (GDGDB)	January 25, 2017

Disease ID	Disease Name	Gene Symbol ▲	Gene ID
DOID:3376	bone osteosarcoma	AADAC PTEN VCP	13 5728 7415
DOID:3361	childhood osteosarcoma	AADAC PTEN VCP	13 5728 7415
DOID:4896	bile duct adenocarcinoma	AADAC STS	13 412
DOID:10763	hypertension	AAH1 ABAT ABO ACE ACSM3 ACT1 ACTC1 ADA ALDH2 ALOX12 ALOX5 ARG1 ARG2 ATP6AP2 ATP6AP2 Abo2 Abo3 Abo Abo Actc1 Actc1 Ada Ada Alox12 Alox5 Alox5 Arg1 Arg1 Arg2 Arg2 BNA5 CAR1 CAT CD14 CG31743 CHGA CHI3L1 CHST12 COMT CTS2 CYP11A1 CYP11B1 CYP11B2 CYP19A1 CYP1A1 CYP1B1 CYP2C9 CYP2J2 CYP2R1 CYP4A11 CYP4A22 CYP4F2 CYP4F8 Chst12 Chst12 Cht10 DDAH1 Ddah1 Ddah1 ENO1 ENO1 ENO2 ENO2 ENTPD2 EPHX2 Entpd2 Entpd2 Ephx2 Ephx2 FADS1 FAH FOL2 FZO1 Fah Fah GCH1 GCK GLCE GPX1 GPX3 Gch1 Gch1 HDAC6 HDAC8 HK2 HOS1 HSD11B1 HSD11B2 HSD17B4 HSD3B1 HSD3B2 HSPA8 HSPG2 Hdac8 Hdac8 Hsepi Hspa8 Hspa8 ICAM1 INPPL1 Idgf1 Idgf2 Idgf3 Idgf4 Inppl1 Inppl1 KL KYNU Kl Kl Kynu Kynu LDHA LGALS3 LIPE LIPG LPL Lipe Lipe Lipg Lipg Lpl Lpl MFN2 MGM1 MTHFD1 Marf Mfn2 NUDT1 Nudt1 Nudt1 OGG1 OGG1 OLR1 OPA1 Ogg1 Ogg1 Ogg1 Opa1 Opa1 PIK3CA PIK3CB PIK3CD PIK3CG PKM PLC1 PLCD1 PON1 PTGDS PTGIS PTGS2 Plcd1 Plcd1 Pon1 Pon1 Pu RHO1 RHO2 RHOA Rhoa Rhoa SHMT1 SLC2A3 STS Sts Sts TBXAS1 VCAM1 abo.1 abo.2.L abo.2 abo.3.L abo.3 abo.4.L abo.4 actc1 ada ada ar cat-4 chst12 chst12a cht-1 daf-2 fah-1 fzo-1 gbgt1l2 gbgt1l3 gbgt1l4 gbgt1l5 gbgt1l8 hdac8 hdac8 inppl1a kynu-1 nudt1 opa1 trol	100 100005565 10013 100145561 100301568 100497509 10159 108698211 108698863 1113 1116 11283 11464 11486 116682 11684 11689 117260 117273 11846 11847 11848 120227 12496 1312 13850 14085 14528 1543 1545 15481 1559 1573 1579 1583 1584 1585 1588 16332 1636 16591 16890 16891 16956 170731 171116 173990 175410 17766 179472 18 180628 180883 180918 18294 18799 18979 2023 2026 2053 20905 217 2184 23576 239 240 24165 24468 24539 24655 24800 25290 25330 26035 2643 2645 28 284541 2876 2878 291437 29215 29221 29244 29275 29383 296504 304322 3099 31581 31806 31926 325179 326156 3283 3284 3290 3291 3295 3312 3339 3355116 3383 34978 34979 34981 35569 363481 3636 37415 383 384 387 387303 3939 394698 3958 3991 3992 4023 406727 406740 407076 41104 412 436919 447881 4521 4522 45320 492332 495825 496434 4968 4973 4976 5290 5291 5293 5294 5315 5333 5444 548703 549437 549858 550054 55501 55869 563897 564156 566487 5730 5740 5743 59031 6296 64157 64467 6470 65030 65038 6515 65270 6916 69219 70 70315 70789 7412 74143 80908 81528 83504 84024 847 850504 850933 851977 852477 8529 853169 853183 854386 854942 855581 855634 855860 855993 856181 856294 856579 8942 929 9365 9388 954 9927
DOID:10534	stomach cancer	AAH1 ABCC1 ACE ADA ADAR AKR1B1 AKR1C3 ANXA4 Ada Ada Adar Adar B4GALNT2 BST2 CACNA2D1 CACNA2D3 CALR CD1D CDA CDD1 CDH13 CYP1A1 CYP2E1 Calr Cda Ces1f DhpD EEF2 EFT1 Eef2 Eef2 GDA GLDC GPX1 GPX3 GUD1 Gda HDAC1 HDAC2 Hdac2 IDH2 KRAS Kras Kras MUTYH Mutyh Mutyh PARP1 PIK3CA PIK3CB PIK3CD PIK3CG PKD1 PTEN PTGS2 Parp1 Parp1 R09H10.3 RAC1 RECK RGN RPD3 Rac1 Rac1 Ras85D Rgn Rgn SDHB ST3GAL6 SULF1 SULF2 TEP1 ZK697.8 ada.S ada ada adr-2 eEF2 eef2.1.L eef2b hda-1 parp-1 parp1 rgn.L rgn rgn	100 1012 103 10402 11486 124872 13629 142 14544 15182 1543 1571 1636 16653 170841 176022 179959 187757 191414 19353 1938 19733 231 23213 234564 24165 24525 25106 25591 266823 2731 2876 2878 29565 3066 307 326929 3355109 3418 35422 363875 373659 380348 3845 38565 403070 40528 41140 41166 4363 436919 444167 448549 4595 496434 5290 5291 5293 5294 5310 55799 55959 560788 56417 5728 5743 5879 6390 684 70603 72269 781 811 81635 8434 850946 851360 851993 855386 855581 855595 8644 9104 912 9615 978
DOID:2841	asthma	AAH1 ABO ACE ACSL3 ADA ADH5 ALOX5 ARG1 ARG2 Abo2 Abo3 Abo Abo Ada Ada Alox5 Alox5 Arg1 Arg1 Arg2 Arg2 CAR1 CAT CD14 CD209 CHAT CHI3L1 CHIA CTS2 CYP2E1 Chia1 Chia Chil3 Cht10 Cht2 DCN EPHX1 Ephx1 Ephx1 HDAC1 HDAC2 Hdac2 ICAM1 IL18R1 IL1RL1 Idgf1 Idgf2 Idgf3 Idgf4 Il18r1 Il1rl1 Il1rl1 LGALS3 LTA4H MBL2 ORMDL1 ORMDL2 PARP1 PLA2G4A PLA2G7 PRG2 PTGS2 Parp1 Parp1 Pla2g4a Pla2g7 RHO1 RHO2 RHOA RPD3 Rhoa Rhoa SFTPA1 SFTPA2 SFTPC SFTPD abo.1 abo.2.L abo.2 abo.3.L abo.3 abo.4.L abo.4 ada.S ada ada arg2.S cht-1 gbgt1l2 gbgt1l3 gbgt1l4 gbgt1l5 gbgt1l8 hda-1 paf-2 parp-1 parp1 pla2g4a pla2g4aa	100 100005565 100145731 100301568 100497509 108698211 108698863 1103 1116 113901 11486 11689 117273 11846 11847 11848 12655 128 13849 142 15182 1571 16182 1634 1636 17082 179959 180628 180704 18783 2052 2181 240 24165 25290 25315 25556 25591 266823 27159 27226 28 29095 29215 29221 296504 30554 3066 30835 31926 3355109 3355116 3383 34978 34979 34981 379198 38223 383 384 38565 387 387303 3958 4048 4153 436919 444167 447881 495825 496434 5321 549437 549858 550054 5553 560788 563897 566487 5743 6440 6441 65270 653509 729238 7941 80908 81600 847 851977 855386 855581 855634 855993 856294 8809 9173 929 94101
DOID:13406	pulmonary sarcoidosis	AAH1 ABO ADA Abo2 Abo3 Abo Abo Ada Ada CHI3L1 CTS2 IL18R1 Idgf1 Idgf2 Idgf3 Idgf4 Il18r1 SFTPA1 abo.1 abo.2.L abo.2 abo.3.L abo.3 abo.4.L abo.4 ada.S ada ada cht-1 gbgt1l2 gbgt1l3 gbgt1l4 gbgt1l5 gbgt1l8	100 100005565 100301568 100497509 108698211 108698863 1116 11486 16182 180628 24165 28 296504 31926 34978 34979 34981 387303 436919 444167 447881 495825 496434 549437 549858 550054 563897 566487 65270 653509 80908 851977 855581 8809
DOID:9352	type 2 diabetes mellitus	AAH1 ACE ACOT2 ADA AKR1B1 ALDH2 ALDOB ALOX12 ATG26 Ada Ada Alox12 BI4 C27A7.3 CAT CD38 CEL CHI3L1 CPT1A CTS2 CYB5R4 CYP11A1 CYP11B2 CYP1A1 CYP2C19 CYP2C8 CYP2C9 CYP2E1 Cd38 Cd38 DAG1 DCN DNM1 DNM1L Dg Dnm1l Dnm1l ENPP1 Enpp1 Enpp1 FOL2 FUCA1 FZO1 Fuca1 Fuca1 Fuca G6PC1 G6PD G6pc1 G6pc1 GCH1 GCK GCKR GFPT1 GFPT2 GGT1 GLO1 GLO1 GPD2 GPX3 Gch1 Gch1 Gckr Gckr HK2 HPSE HSD11B1 HSD11B2 HSD17B3 HSD3B1 ICAM1 IGF2R INPPL1 INSR Idgf1 Idgf2 Idgf3 Idgf4 Inppl1 Inppl1 KL Kl Kl LIPC LIPE LPL Lerp Lipc Lipe Lipe Lpl Lpl MFN2 Marf Mfn2 NAMPT NPP1 NPP2 Nampt Nampt OGA OGG1 OGG1 OGT OXCT1 Oga Oga Oga Ogg1 Ogg1 Ogg1 Ogt Ogt PARP1 PCK1 PDHX PIK3C2A PIK3C2G PIK3CB PIK3CD PKLR PLA2G7 PLAUR PNPLA3 PON1 PON2 PPP1R3A PPP1R3C PRKAA2 PTGDS PTGIS PTGS2 Parp1 Parp1 Pla2g7 Pnpla3 Pon1 Pon1 Pon2 Pon2 Pu REG3G SDC2 SDHB SELL SELP SLC2A2 SLC2A3 SLC2A4 SNF1 SPHK1 SRD5A1 Sdc UGT1A10 UGT1A1 UGT1A6 UGT1A7 UGT1A8 UGT1A9 Ugt1a1 Ugt1a1 Ugt1a6 Ugt1a6a Ugt1a6b Ugt1a7c Ugt1a7c Ugt301D1 Ugt302K1 Ugt303A1 Ugt304A1 Ugt316A1 Ugt35A1 Ugt35C1 Ugt35D1 Ugt35E1 Ugt35E2 Ugt36A1 Ugt36D1 Ugt36E1 Ugt36F1 Ugt37A2 Ugt37A3 Ugt37B1 Ugt37C1 Ugt37C2 Ugt37D1 Ugt37E1 Ugt49B1 Ugt49B2 Ugt50B3 VCAM1 W03G11.3 ada.S ada ada ar atgl-1 cat-4 cht-1 daf-2 dnm1l drp-1 enpp-1 fzo-1 gckr.L inppl1a ogt-1 ogt.1 ogt paf-2 parp-1 parp1 rho-7 sxc ugt-62 ugt1a1 ugt1a6 ugt1a7 ugt1ab	100 100135191 100384891 100489505 10059 10135 1056 10724 108155 10855 10965 1116 113992 114114 11486 11684 116939 12494 130120 1374 142 14377 14528 1543 15450 154516 154968 1557 1558 1559 1571 1583 1585 1605 16332 1634 1636 16591 16890 16956 170731 173990 175410 175591 175910 176000 177336 179472 179663 179665 180628 180704 18294 18605 189173 18979 217 229 231 231103 239 24165 24375 24539 246614 24861 2517 25330 2538 2539 25591 25634 25658 25668 26295 2643 2645 2646 266823 2673 2678 27226 2739 2820 2878 29244 296851 297508 3099 31581 31806 31926 325179 3283 3290 3291 3293 330260 3355109 337685 3383 3482 34978 34979 34981 35105 35137 35138 35139 35486 36281 3636 3643 36773 37415 37420 37447 3772574 393896 394432 394435 394436 398839 3990 3991 40079 4023 406731 41334 41573 41574 42518 42538 43223 436919 43708 44058 444167 496434 4968 5019 5105 51167 5167 5286 5288 5291 5293 5313 5329 53501 53502 53503 53504 53506 53507 53511 53512 53513 53583 53584 5444 5445 54575 54576 54577 54578 54600 54658 5506 5507 553157 5563 560788 564156 5730 5740 5743 59027 6383 6390 6402 6403 65038 6514 6515 6517 6715 71665 74006 7412 76055 7941 80339 8050 81528 83504 84024 847 8473 850391 850686 850886 851977 852088 852477 853183 854582 854942 85496 855009 855581 856699 8877 9365 94284 952 9927 9945
DOID:850	lung disease	AAH1 ACE ADA Ada Ada CAT CNTN2 GPX3 IL18R1 Il18r1 Rrp1 SFTPA1 SFTPA2 SFTPC SFTPD ada ada	100 11486 16182 1636 24165 2878 33500 436919 496434 6440 6441 653509 6900 729238 847 855581 8809
DOID:2297	leptospirosis	AAH1 ACHE ADA Ada Ada MBL2 ada ada	100 11486 24165 4153 43 436919 496434 855581