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intu inturned planar cell polarity protein [ Danio rerio (zebrafish) ]

Gene ID: 100007575, updated on 9-Dec-2024

Summary

Official Symbol
intuprovided by ZNC
Official Full Name
inturned planar cell polarity proteinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-110914-91
See related
Ensembl:ENSDARG00000077639 AllianceGenome:ZFIN:ZDB-GENE-110914-91
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to be involved in several processes, including cilium assembly; limb development; and regulation of smoothened signaling pathway. Predicted to act upstream of or within cell projection organization; establishment of planar polarity; and vesicle-mediated transport. Predicted to be located in cell projection; cell surface; and cytoskeleton. Predicted to be active in cilium and cytoplasm. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy and orofaciodigital syndrome XVII. Orthologous to human INTU (inturned planar cell polarity protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See intu in Genome Data Viewer
Location:
chromosome: 7
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (7709571..7766926, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (7478036..7533539, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene aminoadipate aminotransferase Neighboring gene INO80 complex subunit B Neighboring gene small nucleolar RNA U3 Neighboring gene small nucleolar RNA U3

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization  
involved_in cilium assembly  
acts_upstream_of_or_within cilium assembly  
involved_in cilium assembly  
acts_upstream_of_or_within establishment of planar polarity  
involved_in limb development  
involved_in nervous system development  
involved_in nervous system development  
involved_in regulation of smoothened signaling pathway  
acts_upstream_of_or_within vesicle-mediated transport  
Component Evidence Code Pubs
located_in cell projection  
located_in cell surface  
is_active_in cilium  
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytoplasm  
located_in cytoskeleton  

General protein information

Preferred Names
protein inturned
Names
inturned planar cell polarity effector homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001353932.1NP_001340861.1  protein inturned

    Status: VALIDATED

    Source sequence(s)
    CABZ01030293, CABZ01030294
    UniProtKB/TrEMBL
    A0A0H2UJB2, A0A8M1PT24
    Related
    ENSDARP00000101586.3, ENSDART00000113131.4
    Conserved Domains (1) summary
    cl00117
    Location:199263
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    7709571..7766926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068222130.1XP_068078231.1  protein inturned isoform X1

    UniProtKB/Swiss-Prot
    E7FCN8
    UniProtKB/TrEMBL
    A0A8M1PT24
    Related
    ENSDARP00000142182.1, ENSDART00000173376.2
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