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ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor 6 [ Loxodonta africana (African savanna elephant) ]

Gene ID: 100658524, updated on 11-Apr-2024

Summary

Gene symbol
ARHGEF6
Gene description
Rac/Cdc42 guanine nucleotide exchange factor 6
See related
EnsemblRapid:ENSLAFG00000005561
Gene type
protein coding
RefSeq status
MODEL
Organism
Loxodonta africana
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta
Orthologs
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Genomic context

See ARHGEF6 in Genome Data Viewer
Location:
chromosome: X
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_04 current mLoxAfr1.hap2 (GCF_030014295.1) X NC_087369.1 (159337041..159448035, complement)
102 previous assembly Loxafr3.0 (GCF_000001905.1) Unplaced Scaffold NW_003573509.1 (4476486..4587962)

Chromosome X - NC_087369.1Genomic Context describing neighboring genes Neighboring gene vestigial like family member 1 Neighboring gene CD40 ligand Neighboring gene U6 spliceosomal RNA Neighboring gene small nucleolar RNA SNORD61 Neighboring gene uncharacterized LOC135228801 Neighboring gene RNA binding motif protein X-linked

Genomic regions, transcripts, and products

General gene information

Gene Ontology Provided by RefSeq

Component Evidence Code Pubs
located_in cytoplasm PubMed 
located_in lamellipodium PubMed 

General protein information

Preferred Names
rho guanine nucleotide exchange factor 6

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_030014295.1-RS_2024_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mLoxAfr1.hap2

Genomic

  1. NC_087369.1 Reference mLoxAfr1.hap2

    Range
    159337041..159448035 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023539463.2XP_023395231.1  rho guanine nucleotide exchange factor 6 isoform X3

    UniProtKB/TrEMBL
    G3SWH3
    Related
    ENSLAFP00000026912.2, ENSLAFT00000033457.2
    Conserved Domains (7) summary
    cd12060
    Location:162219
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    cd00160
    Location:276451
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:482579
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00307
    Location:3105
    CH; Calponin homology (CH) domain
    pfam16523
    Location:705791
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:609702
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:115160
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
  2. XM_023539466.2XP_023395234.1  rho guanine nucleotide exchange factor 6 isoform X6

    UniProtKB/TrEMBL
    G3SWH3
    Related
    ENSLAFP00000042098.1, ENSLAFT00000052394.1
    Conserved Domains (7) summary
    cd12060
    Location:162219
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    cd00160
    Location:276451
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:482579
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00307
    Location:3105
    CH; Calponin homology (CH) domain
    pfam16523
    Location:659745
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:603656
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:115160
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
  3. XM_023539464.2XP_023395232.1  rho guanine nucleotide exchange factor 6 isoform X1

    UniProtKB/TrEMBL
    G3SWH3
    Conserved Domains (7) summary
    cd12060
    Location:162219
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    cd00160
    Location:276451
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:482579
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00307
    Location:3105
    CH; Calponin homology (CH) domain
    pfam16523
    Location:712798
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:609709
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:115160
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
  4. XM_023539467.2XP_023395235.1  rho guanine nucleotide exchange factor 6 isoform X8

    UniProtKB/TrEMBL
    G3SWH3
    Conserved Domains (7) summary
    cd12060
    Location:162219
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    cd00160
    Location:245419
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:450547
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00307
    Location:3105
    CH; Calponin homology (CH) domain
    pfam16523
    Location:673759
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:577670
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:115160
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
  5. XM_023539465.2XP_023395233.1  rho guanine nucleotide exchange factor 6 isoform X4

    UniProtKB/TrEMBL
    G3SWH3
    Conserved Domains (7) summary
    cd12060
    Location:162219
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    cd00160
    Location:245419
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:450547
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00307
    Location:3105
    CH; Calponin homology (CH) domain
    pfam16523
    Location:680766
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:577677
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:115160
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
  6. XM_010600039.3XP_010598341.1  rho guanine nucleotide exchange factor 6 isoform X2

    UniProtKB/TrEMBL
    G3SWH3
    Related
    ENSLAFP00000004669.4, ENSLAFT00000005565.4
    Conserved Domains (8) summary
    cd12060
    Location:162219
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    smart00033
    Location:5105
    CH; Calponin homology domain
    cd00160
    Location:276451
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:482579
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:499580
    PH; PH domain
    pfam16523
    Location:708794
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:604705
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:115160
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
  7. XM_010600040.3XP_010598342.1  rho guanine nucleotide exchange factor 6 isoform X5

    UniProtKB/TrEMBL
    G3SWH3
    Related
    ENSLAFP00000025955.2, ENSLAFT00000036901.2
    Conserved Domains (8) summary
    cd12060
    Location:162219
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    smart00033
    Location:5105
    CH; Calponin homology domain
    cd00160
    Location:245419
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:450547
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:467548
    PH; PH domain
    pfam16523
    Location:676762
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:572673
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:115160
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
  8. XM_064277644.1XP_064133714.1  rho guanine nucleotide exchange factor 6 isoform X7

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