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hydroxyacylglutathione hydrolase

Summary

Gene Symbol

HAGH

Organism

Myotis lucifugus (little brown bat)

External Links

NCBI Gene: 102419338
KEGG Gene ID: mlf:102419338
PubChem: 102419338

Annotation

Keyword

Hydrolase
Metal-binding
Mitochondrion
Reference proteome
Signal
Transit peptide
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
G1NU33	Glyoxalase II

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione	IEA	22301074
glutathione metabolic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

ketone catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

aldehyde catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

small molecule catabolic process [inference]

ketone catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

organic substance catabolic process [inference]

ketone catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

aldehyde catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

methylglyoxal metabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

aldehyde catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

lactate metabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

cellular ketone metabolic process [inference]

methylglyoxal metabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

ketone catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

cellular catabolic process [inference]

ketone catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

aldehyde catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

lactate metabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

cellular ketone metabolic process [inference]

methylglyoxal metabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

ketone catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

small molecule catabolic process [inference]

ketone catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

organic substance metabolic process [inference]

cellular aldehyde metabolic process [inference]

methylglyoxal metabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

aldehyde catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

lactate metabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

glutathione metabolic process

cellular ketone metabolic process [inference]

methylglyoxal metabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

ketone catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

organic substance catabolic process [inference]

ketone catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

aldehyde catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

organic hydroxy compound metabolic process [inference]

lactate metabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

methylglyoxal metabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

aldehyde catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

lactate metabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

cellular ketone metabolic process [inference]

methylglyoxal metabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

ketone catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

cellular catabolic process [inference]

ketone catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

aldehyde catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

Displaying 1 entry
GO Term	Evidence Code	PMID
mitochondrion	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying 1 entry
GO Term	Evidence Code	PMID
hydroxyacylglutathione hydrolase activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

thiolester hydrolase activity [inference]

hydroxyacylglutathione hydrolase activity

Gene Ontology information from NCBI Gene and UniProt.

Rhea

H₂O + (R)-S-lactoylglutathione

H⁺ + (R)-lactate + glutathione

Enzyme

3.1.2.6

PMID

H₂O + an S-(2-hydroxyacyl)glutathione

H⁺ + glutathione + a 2-hydroxy carboxylate

Enzyme

3.1.2.6

PMID

Ortholog

Displaying entries **51 - 59** of 59 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Podarcis muralis	114584919		PODMU03152
Podarcis muralis	114584923		PODMU03152
Sinocyclocheilus grahami	107586173		SINGR01220
Equus asinus asinus	106836218		EQUAS28089
Chelonoidis abingdonii	116814824		CHEAB02270
Athene cunicularia	113485478		ATHCN15197
Propithecus coquereli	105813151		PROCO03408
Corvus moneduloides	116452000		CORMO04938
Carlito syrichta	103272853		CARSF04045

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024