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ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2

Summary

Gene Symbol

ST6GALNAC2

Aliases

ST6GalNAII
STHM

Organism

Homo sapiens (human)

External Links

NCBI Gene

10610

GGDB ID

gg057

HGNC

10867

mRNA

NM_006456

map

17q25.1

Protein

NP_006447

OMIM

610137

KEGG Gene ID

hsa:10610

PubChem

10610

Alliance of Genome Resources

HGNC:10867

Annotation

Keyword

3D-structure
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UJ37	GalNAc alpha-2,6-sialyltransferase II ST6GalNAc II SThM Sialyltransferase 7B

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein glycosylation	IDA	29251719
protein O-linked glycosylation	IDA	10742600
protein O-linked glycosylation	IBA
O-glycan processing	TAS
viral protein processing	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

protein sialylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

protein sialylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

protein sialylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

protein sialylation

macromolecule glycosylation [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

sialylation [inference]

protein sialylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

protein sialylation

viral process [inference]

viral protein processing

Displaying 1 entry
GO Term	Evidence Code	PMID
Golgi membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	TAS
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	IDA	10742600 29251719
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	IBA
sialyltransferase activity	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

sialyltransferase activity

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sialyltransferase

Functional Category

H: Coenzyme transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
sialyltransferase activity
transferase activity

Displaying **all 2** entries
InterPro
GT29-like superfamiliy
Glycosyl transferase family 29

GlycoGene Database (GGDB)

GGDB ID

gg057

Gene Symbol

ST6GALNAC2

Reactions

Displaying **all 2** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
CMP-Neu5Ac	G00031MO	Ser/Thr	G56682BC	Ser/Thr	10742600
CMP-Neu5Ac	G65562ZE	Ser/Thr	G01614ZM	Ser/Thr	10742600

Displaying **all 2** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
CMP-Neu5Ac	G00031MO	Ser/Thr	G56682BC	Ser/Thr	10536037 10742600
CMP-Neu5Ac	G65562ZE	Ser/Thr	G01614ZM	Ser/Thr	10536037 10742600

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Donor	Acceptor	Reducing terminal(Acceptor)	Reference
CMP-Neu5Ac	G49108TO	benzyl	11062056
CMP-Neu5Ac	G00056MO	octyl	10742600
CMP-Neu5Ac	G46677TE	ceramide	11062056
CMP-Neu5Ac	G57321FI	Ser/Thr	10536037
CMP-Neu5Ac	G05212BT		11062056

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	XP_221134	XM_221134
Mus musculus	NP_033206	NM_009180

KEGG BRITE Database

Orthology

K06616

Name

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7B) [EC:2.4.3.3]

References

10742600

Reactions

Displaying **all 2** entries
KEGG Reaction	Enzyme	Acceptor	Product
R12704	2.4.3.3	G00031MO	G28694FA
R05914	2.4.3.3 2.4.3.7	G65562ZE	G01614ZM

Rhea

RHEA:11136

a β-D-galactosyl-(1→3)-N-acetyl-α-D-galactosaminyl derivative + CMP-N-acetyl-β-neuraminate

a β-D-galactosyl-(1→3)-[N-acetyl-α-neuraminyl-(2→6)]-N-acetyl-α-D-galactosaminyl derivative + H⁺ + CMP

Enzyme

2.4.3.3

PMID

Ortholog

Displaying entries **11 - 20** of 58 in total

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Species	Gene ID	Orthologous MAtrix
Taeniopygia guttata	100224588	TAEGU06932
Pongo abelii	100436103	PONAB12480
Loxodonta africana	100673802	LOXAF07188
Cavia porcellus	100725069	CAVPO24670
Otolemur garnettii	100964755	OTOGA14746
Pan paniscus	100991286	PANPA18008
Papio anubis	101023130	PAPAN15130
Saimiri boliviensis boliviensis	101053227	SAIBB19522
Felis catus	101098908	FELCA30951
Gorilla gorilla gorilla	101131207	GORGO32899

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements