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ncstn.S nicastrin S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 108700373, updated on 27-Dec-2024

Summary

Official Symbol
ncstn.S
Official Full Name
nicastrin S homeolog
Primary source
Xenbase:XB-GENE-17339043
Locus tag
XELAEV_18042802mg
See related
EnsemblRapid:ENSXLAG00005022959 AllianceGenome:Xenbase:XB-GENE-17339043
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Summary
Predicted to act upstream of or within Notch signaling pathway and protein processing. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; hidradenitis suppurativa; and schizophrenia. Orthologous to human NCSTN (nicastrin). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See ncstn.S in Genome Data Viewer
Location:
chromosome: 8S
Exon count:
17
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8S NC_054386.1 (99208641..99227770, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8S NC_030739.1 (94174759..94192876, complement)

Chromosome 8S - NC_054386.1Genomic Context describing neighboring genes Neighboring gene VANGL planar cell polarity protein 2 S homeolog Neighboring gene nescient helix-loop-helix 1 S homeolog Neighboring gene COPI coat complex subunit alpha S homeolog Neighboring gene MLLT11, transcription factor 7 cofactor S homeolog

Genomic regions, transcripts, and products

General gene information

Gene Ontology Provided by Xenbase

Component Evidence Code Pubs
located_in membrane  
located_in plasma membrane  

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    99208641..99227770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018233504.2XP_018088993.1  nicastrin isoform X2

    UniProtKB/TrEMBL
    A0A8J0TSP2
    Related
    ENSXLAP00005067717.1, ENSXLAT00005069251.1
  2. XM_018233502.2XP_018088991.1  nicastrin isoform X1

    UniProtKB/TrEMBL
    A0A1L8F4M3, A0A974C4X3
    Related
    ENSXLAP00005067586.1, ENSXLAT00005069120.1
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