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epoxide hydrolase 1, microsomal

Summary

Gene Symbol

Ephx1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

13849

PubChem

13849

Alliance of Genome Resources

MGI:95405

Annotation

Keyword

Acetylation
Aromatic hydrocarbons catabolism
Detoxification
Direct protein sequencing
Endoplasmic reticulum
Hydrolase
Lipid metabolism
Methylation
Microsome
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9D379	Epoxide hydratase Microsomal epoxide hydrolase
E9PWK1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
response to toxic substance	IEA
arachidonic acid metabolic process	ISS
arachidonic acid metabolic process	ISO
arachidonic acid metabolic process	IBA
diol biosynthetic process	ISO

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

organic substance catabolic process [inference]

hydrocarbon catabolic process

biosynthetic process [inference]

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process

organic substance biosynthetic process [inference]

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

heterocycle metabolic process [inference]

epoxide metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

diol biosynthetic process

polyol biosynthetic process [inference]

diol biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

ether metabolic process [inference]

epoxide metabolic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

ether metabolic process [inference]

epoxide metabolic process

hydrocarbon metabolic process [inference]

hydrocarbon catabolic process

olefinic compound metabolic process [inference]

arachidonic acid metabolic process

organic cyclic compound metabolic process [inference]

epoxide metabolic process

organic substance catabolic process [inference]

hydrocarbon catabolic process

organic substance biosynthetic process [inference]

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

diol biosynthetic process

polyol biosynthetic process [inference]

diol biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

heterocycle metabolic process [inference]

epoxide metabolic process

response to stimulus [inference]

response to chemical [inference]

response to toxic substance

response to organic substance [inference]

response to organic cyclic compound [inference]

response to polycyclic arene

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IEA
membrane	ISO
intracellular membrane-bounded organelle	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
epoxide hydrolase activity	ISS
epoxide hydrolase activity	ISO
epoxide hydrolase activity	IBA
oxysterol binding	IMP	34799735
enzyme binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ether bonds [inference]

ether hydrolase activity [inference]

binding [inference]

protein binding [inference]

enzyme binding

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

oxysterol binding

organic cyclic compound binding [inference]

steroid binding [inference]

sterol binding [inference]

oxysterol binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Hydrolase

Functional Category

H: Coenzyme transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
catalytic activity
epoxide hydrolase activity
epoxide metabolic process
ether hydrolase activity
hydrolase activity

Displaying **all 4** entries
InterPro
Alpha/Beta hydrolase fold
Epoxide hydrolase, N-terminal
Epoxide hydrolase-like
Epoxide hydrolase

Rhea

RHEA:55764

1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H₂O

2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol

Enzyme

3.3.2.9

PMID

RHEA:23900

H₂O + cis-stilbene oxide

(1R,2R)-hydrobenzoin

Enzyme

3.3.2.9

PMID

RHEA:15825

AZD1979 + H₂O

AZD1979 oxetane hydrolysis product + H⁺

Enzyme

3.3.2.9

PMID

28600384

Ortholog

Displaying entries **1 - 10** of 50 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	2052		HUMAN54931
Xenopus tropicalis	13849	Xenbase:XB-GENE-995306
Rattus norvegicus	25315		RATNO06237
Sus scrofa	397639		PIGXX00121
Pan troglodytes	457777		PANTR23802
Canis lupus familiaris	480113		CANLF17346
Bos taurus	535293		BOVIN08086
Macaca mulatta	700180		MACMU24741
Oryctolagus cuniculus	100009104		RABIT05693
Monodelphis domestica	100025778		MONDO11151