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cytochrome P450 family 2 subfamily C member 19

Summary

Gene Symbol

CYP2C19

Aliases

CPCJ
P450IIC19

Organism

Homo sapiens (human)

External Links

NCBI Gene

1557

HGNC

2621

KEGG Gene ID

hsa:1557

PubChem

1557

Alliance of Genome Resources

HGNC:2621

Annotation

Keyword

3D-structure
Direct protein sequencing
Fatty acid metabolism
Heme
Membrane
Microsome
Monooxygenase
NADP
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P33261	(R)-limonene 6-monooxygenase (S)-limonene 6-monooxygenase (S)-limonene 7-monooxygenase CYPIIC17 CYPIIC19 Cytochrome P450-11A Cytochrome P450-254C Fenbendazole monooxygenase (4'-hydroxylating) Mephenytoin 4-hydroxylase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
monoterpenoid metabolic process	IDA	16401082
epoxygenase P450 pathway	IBA TAS
xenobiotic catabolic process	IDA	19029318
omega-hydroxylase P450 pathway
steroid metabolic process	IMP	18356043

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

xenobiotic catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

arachidonic acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

xenobiotic metabolic process

xenobiotic catabolic process

cellular catabolic process [inference]

xenobiotic catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

arachidonic acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

monoterpenoid metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

arachidonic acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

monoterpenoid metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

arachidonic acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

arachidonic acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

arachidonic acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

monoterpenoid metabolic process

olefinic compound metabolic process [inference]

arachidonic acid metabolic process [inference]

organic cyclic compound metabolic process [inference]

steroid metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

arachidonic acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

xenobiotic metabolic process

xenobiotic catabolic process

cellular catabolic process [inference]

xenobiotic catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

arachidonic acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

monoterpenoid metabolic process

Displaying **all 4** entries
GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IBA IDA
cytoplasm	IBA
endoplasmic reticulum membrane
plasma membrane	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entries **11 - 14** of 14 in total

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GO Term	Evidence Code	PMID
aromatase activity	IEA
(S)-limonene 6-monooxygenase activity	IEA
heme binding	IBA IDA	23118231
arachidonic acid epoxygenase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

monooxygenase activity

arachidonic acid monooxygenase activity [inference]

arachidonic acid epoxygenase activity

steroid hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

limonene monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

aromatase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

arachidonic acid monooxygenase activity [inference]

arachidonic acid epoxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

limonene monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

aromatase activity

long-chain fatty acid omega-1 hydroxylase activity

binding [inference]

protein binding [inference]

enzyme binding

small molecule binding [inference]

oxygen binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000165841

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K17721

Name

cytochrome P450 family 2 subfamily C19 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.75 1.14.14.-]

References

2009263

Rhea

RHEA:17945

O₂ + (4S)-limonene

H₂O + H⁺ + (1S,5R)-carveol

Enzyme

1.14.14.51

PMID

RHEA:18957

O₂ + (4R)-limonene

H₂O + H⁺ + (1R,5S)-carveol

Enzyme

1.14.14.53

PMID

9662532

RHEA:17149

an organic molecule + O₂

H₂O + H⁺ + an alcohol

Enzyme

1.14.14.1

PMID

RHEA:23432

O₂ + (4S)-limonene

(4S)-perillyl alcohol + H₂O + H⁺

Enzyme

1.14.14.52

PMID

2297225

RHEA:56292

O₂ + fenbendazole

4'-hydroxyfenbendazole + H₂O + H⁺

Enzyme

1.14.14.75

PMID

23959307

Disease

Disease Ontology

Displaying entries **161 - 170** of **213** in total

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DO ID	Disease Name	Source
DOID:4448	macular degeneration	DisGeNET
DOID:4480	achondroplasia	DisGeNET DisGeNET
DOID:4607	biliary tract cancer	DisGeNET
DOID:4661	multiple chemical sensitivity	Alliance of Genome Resources
DOID:4674	androgen insensitivity syndrome	DisGeNET
DOID:4766	embryoma	DisGeNET
DOID:4905	pancreatic carcinoma	DisGeNET
DOID:4964	neurotic disorder	DisGeNET DisGeNET DisGeNET
DOID:4990	essential tremor	DisGeNET
DOID:5162	arteriolosclerosis	DisGeNET DisGeNET