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interleukin 1 receptor-like 1

Summary

Gene Symbol

Il1rl1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

17082

PubChem

17082

Alliance of Genome Resources

MGI:98427

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Hydrolase
Immunoglobulin domain
Isopeptide bond
NAD
Phosphoprotein
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P14719	Interleukin-33 receptor alpha chain Lymphocyte antigen 84 Protein ST2 Protein T1
Q5D095

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
negative regulation of T-helper 1 type immune response	IGI	18268038
inflammatory response	IMP	34644537
negative regulation of cell population proliferation	ISO
response to wounding	IDA	31674275
macrophage differentiation	IMP	34644537

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

interleukin-33-mediated signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

response to wounding

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 1 type immune response

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

regulation of macrophage activation [inference]

positive regulation of macrophage activation

regulation of immune response [inference]

regulation of adaptive immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 1 type immune response

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 1 type immune response

regulation of T-helper 1 type immune response [inference]

negative regulation of T-helper 1 type immune response

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 1 type immune response

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of cytokine production [inference]

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of type II interferon production [inference]

negative regulation of type II interferon production

regulation of interleukin-5 production [inference]

positive regulation of interleukin-5 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of cytokine production [inference]

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of type II interferon production [inference]

negative regulation of type II interferon production

regulation of interleukin-5 production [inference]

positive regulation of interleukin-5 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of cytokine production [inference]

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of type II interferon production [inference]

negative regulation of type II interferon production

regulation of interleukin-5 production [inference]

positive regulation of interleukin-5 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 1 type immune response

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 1 type immune response

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

regulation of inflammatory response [inference]

positive regulation of inflammatory response

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 1 type immune response

regulation of immune response [inference]

regulation of adaptive immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 1 type immune response

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 1 type immune response

regulation of T-helper 1 type immune response [inference]

negative regulation of T-helper 1 type immune response

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 1 type immune response

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

regulation of inflammatory response [inference]

positive regulation of inflammatory response

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

interleukin-33-mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of cytokine production [inference]

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of type II interferon production [inference]

negative regulation of type II interferon production

regulation of interleukin-5 production [inference]

positive regulation of interleukin-5 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

regulation of macrophage activation [inference]

positive regulation of macrophage activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of cytokine production [inference]

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of type II interferon production [inference]

negative regulation of type II interferon production

regulation of interleukin-5 production [inference]

positive regulation of interleukin-5 production

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

regulation of macrophage activation [inference]

positive regulation of macrophage activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

Displaying entries **6 - 10** of 14 in total

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GO Term	Evidence Code	PMID
plasma membrane	IBA
focal adhesion	ISO
focal adhesion	IEA
external side of plasma membrane	ISO
external side of plasma membrane	IDA	12714518 19666510

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

external encapsulating structure [inference]

extracellular matrix

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
interleukin-33 binding	IBA
interleukin-33 binding	IPI	29045903
interleukin-33 receptor activity	ISO
interleukin-33 receptor activity	IEA
NAD+ nucleosidase activity

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

NAD+ nucleosidase activity

NAD+ nucleotidase, cyclic ADP-ribose generating

binding [inference]

protein binding

cytokine binding [inference]

interleukin-33 binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

immune receptor activity [inference]

cytokine receptor activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

Rhea

RHEA:16301

H₂O + NAD⁺

H⁺ + nicotinamide + ADP-D-ribose

Enzyme

PMID

Ortholog

Displaying entries **1 - 10** of 50 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	9173	ZFIN:ZDB-GENE-060621-4	HUMAN64129
Danio rerio	17082	ZFIN:ZDB-GENE-060621-4
Rattus norvegicus	25556	ZFIN:ZDB-GENE-060621-4	RATNO44059
Bos taurus	520709		BOVIN02055
Canis lupus familiaris	611442		CANLF01742
Macaca mulatta	711893		MACMU08675
Monodelphis domestica	100017856		MONDO31426
Equus caballus	100058357		HORSE10427
Pongo abelii	100189670		PONAB22990
Taeniopygia guttata	100232380		TAEGU10395

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements