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Major facilitator superfamily (MFS) profile domain-containing protein;putative vesicular glutamate transporter eat-4

Summary

Gene Symbol

eat-4

Organism

Caenorhabditis elegans

External Links

NCBI Gene

176291

PubChem

176291

Alliance of Genome Resources

WB:WBGene00001135

Annotation

Keyword

Cell membrane
Glycoprotein
Neurotransmitter transport
Reference proteome
Sodium transport
Symport
Synapse
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
S6DQ91
P34644	Abnormal pharyngeal pumping eat-4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
positive regulation of male mating behavior	IMP	28065609
sodium ion transport	IEA
regulation of synapse structure or activity	IBA
L-glutamate transmembrane transport	IEA ISS	9870947
regulation of nematode pharyngeal pumping	IGI IMP	12750328

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glutamatergic

transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

multicellular organismal process [inference]

behavior [inference]

locomotory behavior [inference]

adult locomotory behavior

adult behavior [inference]

adult locomotory behavior

response to stimulus [inference]

response to stress [inference]

response to osmotic stress [inference]

hyperosmotic response

response to external stimulus [inference]

response to mechanical stimulus

response to abiotic stimulus [inference]

response to osmotic stress [inference]

hyperosmotic response

response to mechanical stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport

monoatomic anion transport

neurotransmitter transport

neurotransmitter loading into synaptic vesicle

transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

amino acid transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

amino acid transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

nitrogen compound transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

amide transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

establishment of localization in cell [inference]

neurotransmitter loading into synaptic vesicle

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glutamatergic

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of backward locomotion

regulation of backward locomotion [inference]

positive regulation of backward locomotion

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of backward locomotion

positive regulation of multicellular organismal process [inference]

positive regulation of behavior [inference]

positive regulation of male mating behavior

positive regulation of reproductive process [inference]

positive regulation of male mating behavior

negative regulation of biological process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of behavior [inference]

negative regulation of male mating behavior [inference]

negative regulation of turning behavior involved in mating

negative regulation of reproductive process [inference]

negative regulation of male mating behavior [inference]

negative regulation of turning behavior involved in mating

regulation of multicellular organismal process [inference]

regulation of behavior [inference]

positive regulation of behavior [inference]

positive regulation of male mating behavior

negative regulation of behavior [inference]

negative regulation of male mating behavior [inference]

negative regulation of turning behavior involved in mating

regulation of feeding behavior [inference]

regulation of eating behavior [inference]

regulation of nematode pharyngeal pumping

regulation of male mating behavior [inference]

regulation of turning behavior involved in mating [inference]

negative regulation of turning behavior involved in mating

negative regulation of male mating behavior [inference]

negative regulation of turning behavior involved in mating

positive regulation of male mating behavior

positive regulation of multicellular organismal process [inference]

positive regulation of behavior [inference]

positive regulation of male mating behavior

negative regulation of multicellular organismal process [inference]

negative regulation of behavior [inference]

negative regulation of male mating behavior [inference]

negative regulation of turning behavior involved in mating

regulation of reproductive process [inference]

regulation of male mating behavior [inference]

regulation of turning behavior involved in mating [inference]

negative regulation of turning behavior involved in mating

negative regulation of male mating behavior [inference]

negative regulation of turning behavior involved in mating

positive regulation of male mating behavior

negative regulation of reproductive process [inference]

negative regulation of male mating behavior [inference]

negative regulation of turning behavior involved in mating

positive regulation of reproductive process [inference]

positive regulation of male mating behavior

regulation of biological quality [inference]

regulation of synapse structure or activity

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
synaptic vesicle membrane	IBA ISS	9870947
membrane	IEA
presynapse	IEA
plasma membrane	IEA
excitatory synapse	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

cell junction [inference]

synapse

excitatory synapse

presynapse

Displaying **all 5** entries
GO Term	Evidence Code	PMID
symporter activity	IEA
glutamate:sodium symporter activity	ISS	9870947
L-glutamate transmembrane transporter activity	IBA
transmembrane transporter activity	IEA
neurotransmitter transmembrane transporter activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity

neurotransmitter transmembrane transporter activity

organic acid transmembrane transporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

acidic amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

L-amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

acidic amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

L-amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

amide transmembrane transporter activity [inference]

salt transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

transporter

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
MFS transporter superfamily
Major facilitator superfamily domain
Major facilitator superfamily

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
axon	PMID:27151641

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0080855	Parkinsonism	Alliance of Genome Resources
DOID:0110555	autosomal dominant nonsyndromic deafness 25	Alliance of Genome Resources
DOID:11446	sciatic neuropathy	Alliance of Genome Resources
DOID:1289	neurodegenerative disease	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources
DOID:224	transient cerebral ischemia	Alliance of Genome Resources
DOID:5463	cochlear disease	Alliance of Genome Resources
DOID:9784	trichinosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 26 in total

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Species	Gene ID	Alliance of Genome Resources
Drosophila melanogaster	33427	FB:FBgn0031424
Homo sapiens	57030	HGNC:16704
Homo sapiens	57084	HGNC:16703
Mus musculus	72961	MGI:1920211
Rattus norvegicus	84487	RGD:620531
Rattus norvegicus	116638	RGD:620101
Mus musculus	140919	MGI:2156052
Mus musculus	216227	MGI:3039629
Homo sapiens	246213	HGNC:20151
Rattus norvegicus	266767	RGD:628870

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements