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kin-21 Tyrosine-protein kinase [ Caenorhabditis elegans ]

Gene ID: 177826, updated on 9-Dec-2024

Summary

Official Symbol
kin-21
Official Full Name
Tyrosine-protein kinase
Primary source
WormBase:WBGene00002204
Locus tag
CELE_W08D2.8
See related
AllianceGenome:WB:WBGene00002204
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein tyrosine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human FER (FER tyrosine kinase) and FES (FES proto-oncogene, tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See kin-21 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (9832886..9834870)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene mRNA transport homolog 4 Neighboring gene pseudo Neighboring gene Major Sperm Protein Neighboring gene Major sperm protein 10/36/56/76

Interactions

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding  
enables non-membrane spanning protein tyrosine kinase activity  
enables non-membrane spanning protein tyrosine kinase activity  
enables protein kinase activity  
enables protein tyrosine kinase activity  
enables signaling receptor binding  
Process Evidence Code Pubs
involved_in cell differentiation  
involved_in cell surface receptor protein tyrosine kinase signaling pathway  
involved_in protein phosphorylation  
Component Evidence Code Pubs
is_active_in plasma membrane  

General protein information

Preferred Names
Tyrosine-protein kinase
NP_501758.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9832886..9834870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069357.4NP_501758.2  Tyrosine-protein kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501758.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBM6
    Conserved Domains (3) summary
    smart00219
    Location:178431
    TyrKc; Tyrosine kinase, catalytic domain
    smart00252
    Location:71146
    SH2; Src homology 2 domains
    cd00192
    Location:180432
    PTKc; Catalytic domain of Protein Tyrosine Kinases
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