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aagr-3 Glucosidase II subunit alpha [ Caenorhabditis elegans ]

Gene ID: 179364, updated on 4-Jan-2025

Summary

Official Symbol
aagr-3
Official Full Name
Glucosidase II subunit alpha
Primary source
WormBase:WBGene00009583
Locus tag
CELE_F40F9.6
See related
AllianceGenome:WB:WBGene00009583
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables alpha-1,4-glucosidase activity. Involved in glycogen catabolic process. Predicted to be located in lysosome. Is expressed in anal depressor muscle; intestine; nervous system; pharynx; and rectal epithelium. Human ortholog(s) of this gene implicated in polycystic kidney disease; polycystic kidney disease 3; and polycystic liver disease. Orthologous to human GANAB (glucosidase II alpha subunit). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See aagr-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (9725984..9729512, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Proton-coupled folate transporter Neighboring gene Transcription factor CBF/NF-Y/archaeal histone domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene EF-hand domain-containing protein

Genomic regions, transcripts, and products

Genomic Sequence:
NC_003283.11

Interactions

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables alpha-1,4-glucosidase activity PubMed 
enables alpha-glucosidase activity  
enables alpha-glucosidase activity  
enables carbohydrate binding  
enables catalytic activity  
enables hydrolase activity, acting on glycosyl bonds  
enables hydrolase activity, hydrolyzing O-glycosyl compounds  
Process Evidence Code Pubs
involved_in N-glycan processing  
involved_in carbohydrate metabolic process  
involved_in glycogen catabolic process PubMed 
Component Evidence Code Pubs
located_in lysosome PubMed 

General protein information

Preferred Names
Glucosidase II subunit alpha
NP_001263844.1
  • Confirmed by transcript evidence
NP_505507.1
  • Confirmed by transcript evidence
NP_505508.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    9725984..9729512 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073106.2NP_505507.1  Glucosidase II subunit alpha [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505507.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20239
    Conserved Domains (3) summary
    cd06603
    Location:358827
    GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
    cd14752
    Location:229358
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    pfam17137
    Location:803875
    DUF5110; Domain of unknown function (DUF5110)
  2. NM_073107.8NP_505508.1  Glucosidase II subunit alpha [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505508.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U3F8
    Conserved Domains (3) summary
    cd06603
    Location:344813
    GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
    cd14752
    Location:215344
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    pfam17137
    Location:789861
    DUF5110; Domain of unknown function (DUF5110)
  3. NM_001276915.3NP_001263844.1  Glucosidase II subunit alpha [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263844.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    J7SA48
    Conserved Domains (2) summary
    cd06603
    Location:93562
    GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
    cd14752
    Location:193
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
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