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ATP-binding cassette, sub-family B member 1B

Summary

Gene Symbol

Abcb1b

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

18669

PubChem

18669

Alliance of Genome Resources

MGI:97568

Annotation

Keyword

ATP-binding
Cell membrane
Cytoplasm
Glycoprotein
Lipid transport
Phosphoprotein
Reference proteome
Repeat
Translocase
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B2RUR3
P06795	ATP-binding cassette sub-family B member 1B Multidrug resistance protein 1B P-glycoprotein 1 Phospholipid transporter ABCB1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
phospholipid transport	IEA
xenobiotic transport across blood-brain barrier	ISO
establishment of endothelial blood-brain barrier	ISO
ceramide translocation	IBA ISO
regulation of response to osmotic stress	ISO

GO Hierarchy

biological process

cellular process [inference]

cell population proliferation [inference]

stem cell proliferation

cell cycle process [inference]

cell cycle phase transition [inference]

mitotic cell cycle phase transition [inference]

G2/M transition of mitotic cell cycle

cell cycle G2/M phase transition [inference]

G2/M transition of mitotic cell cycle

mitotic cell cycle process [inference]

mitotic cell cycle phase transition [inference]

G2/M transition of mitotic cell cycle

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

endothelial cell development [inference]

establishment of endothelial barrier [inference]

establishment of endothelial blood-brain barrier

establishment of blood-brain barrier [inference]

establishment of endothelial blood-brain barrier

transmembrane transport

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane

xenobiotic detoxification by transmembrane export across the plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

regulation of membrane lipid distribution [inference]

lipid translocation

phospholipid translocation

sphingolipid translocation [inference]

ceramide translocation

export from cell [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane

xenobiotic detoxification by transmembrane export across the plasma membrane

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier [inference]

xenobiotic transport across blood-brain barrier

tissue remodeling [inference]

Sertoli cell barrier remodeling

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

epithelial cell development [inference]

endothelial cell development [inference]

establishment of endothelial barrier [inference]

establishment of endothelial blood-brain barrier

establishment of blood-brain barrier [inference]

establishment of endothelial blood-brain barrier

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

endothelial cell development [inference]

establishment of endothelial barrier [inference]

establishment of endothelial blood-brain barrier

establishment of blood-brain barrier [inference]

establishment of endothelial blood-brain barrier

response to stimulus [inference]

response to chemical [inference]

response to xenobiotic stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

vascular transport [inference]

transport across blood-brain barrier [inference]

xenobiotic transport across blood-brain barrier

xenobiotic transport

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

xenobiotic transport across blood-brain barrier

transmembrane transport

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane

xenobiotic detoxification by transmembrane export across the plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport

transepithelial transport

organic substance transport [inference]

lipid transport [inference]

phospholipid transport

phospholipid translocation

lipid translocation

phospholipid translocation

sphingolipid translocation [inference]

ceramide translocation

ceramide transport [inference]

ceramide translocation

organic anion transport [inference]

carboxylic acid transport [inference]

carboxylic acid transmembrane transport

organophosphate ester transport [inference]

phospholipid transport

phospholipid translocation

organic acid transport [inference]

carboxylic acid transport [inference]

carboxylic acid transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport

nitrogen compound transport [inference]

amide transport [inference]

ceramide transport [inference]

ceramide translocation

sphingolipid translocation [inference]

ceramide translocation

export from cell [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane

xenobiotic detoxification by transmembrane export across the plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of anion channel activity [inference]

positive regulation of anion channel activity

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of monoatomic anion transmembrane transport [inference]

regulation of anion channel activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of monoatomic ion transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of monoatomic anion transmembrane transport [inference]

regulation of anion channel activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

positive regulation of monoatomic anion transport [inference]

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of monoatomic anion transport [inference]

positive regulation of monoatomic anion transport [inference]

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of monoatomic anion transmembrane transport [inference]

regulation of anion channel activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of chloride transport

positive regulation of transport [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

positive regulation of monoatomic anion transport [inference]

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

positive regulation of transport [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

positive regulation of monoatomic anion transport [inference]

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of response to stimulus [inference]

regulation of response to stress [inference]

regulation of response to osmotic stress

regulation of cellular process [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of anion channel activity [inference]

positive regulation of anion channel activity

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of monoatomic anion transmembrane transport [inference]

regulation of anion channel activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of biological quality [inference]

regulation of membrane lipid distribution [inference]

lipid translocation

phospholipid translocation

sphingolipid translocation [inference]

ceramide translocation

regulation of molecular function [inference]

regulation of transporter activity [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of anion channel activity [inference]

positive regulation of anion channel activity

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of molecular function [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
membrane	ISO
intercellular canaliculus	IDA	12068294
apical plasma membrane	IBA IEA ISO
plasma membrane	ISO
cell surface	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

plasma membrane region [inference]

apical plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

intercellular canaliculus

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

side of membrane [inference]

external side of plasma membrane [inference]

external side of apical plasma membrane

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
phosphatidylethanolamine flippase activity	ISO
phosphatidylcholine floppase activity	IBA IEA ISO
ceramide floppase activity	ISO
ATP hydrolysis activity	IEA
xenobiotic transmembrane transporter activity	IBA ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

lipid transporter activity [inference]

phospholipid transporter activity [inference]

phosphatidylcholine transporter activity [inference]

phosphatidylcholine floppase activity

glycerophospholipid flippase activity [inference]

phosphatidylethanolamine flippase activity

sphingolipid transporter activity [inference]

sphingolipid floppase activity [inference]

ceramide floppase activity

intramembrane lipid transporter activity [inference]

ATPase-coupled intramembrane lipid transporter activity [inference]

flippase activity [inference]

glycerophospholipid flippase activity [inference]

phosphatidylethanolamine flippase activity

floppase activity

sphingolipid floppase activity [inference]

ceramide floppase activity

phosphatidylcholine floppase activity

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity

efflux transmembrane transporter activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity [inference]

ABC-type xenobiotic transporter activity

xenobiotic transmembrane transporter activity

ABC-type xenobiotic transporter activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity [inference]

ABC-type xenobiotic transporter activity

ATPase-coupled intramembrane lipid transporter activity [inference]

flippase activity [inference]

glycerophospholipid flippase activity [inference]

phosphatidylethanolamine flippase activity

floppase activity

sphingolipid floppase activity [inference]

ceramide floppase activity

phosphatidylcholine floppase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ABC

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter type 1, transmembrane domain superfamily
ABC transporter type 1, transmembrane domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying entries **1 - 10** of 43 in total

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DO ID	Disease Name	Source
DOID:0050848	obstructive sleep apnea	Alliance of Genome Resources
DOID:0050861	colorectal adenocarcinoma	Alliance of Genome Resources
DOID:0060750	familial temporal lobe epilepsy 3	Alliance of Genome Resources
DOID:0080208	metabolic dysfunction-associated steatotic liver disease	Alliance of Genome Resources
DOID:0080797	nasal type extranodal NK/T-cell lymphoma	Alliance of Genome Resources
DOID:0110893	inflammatory bowel disease 13	Alliance of Genome Resources
DOID:10159	osteonecrosis	Alliance of Genome Resources
DOID:10939	antisocial personality disorder	Alliance of Genome Resources
DOID:1168	familial hyperlipidemia	Alliance of Genome Resources
DOID:12365	malaria	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **117** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	5243		HGNC:40
Rattus norvegicus	24646	10116_1:0019a1	RGD:3318	RATNO30682
Drosophila melanogaster	36428		FB:FBgn0004512
Drosophila melanogaster	36582		FB:FBgn0010241
Drosophila melanogaster	38725		FB:FBgn0035695
Drosophila melanogaster	38726		FB:FBgn0004513
Rattus norvegicus	170913	10116_1:001c63
Caenorhabditis elegans	172262		WB:WBGene00003996
Caenorhabditis elegans	178215		WB:WBGene00003995
Caenorhabditis elegans	180165		WB:WBGene00004003

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements