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cadherin EGF LAG seven-pass G-type receptor 3

Summary

Gene Symbol

CELSR3

Organism

Homo sapiens (human)

External Links

NCBI Gene

1951

PubChem

1951

Alliance of Genome Resources

HGNC:3230

Annotation

Keyword

Alternative splicing
Calcium
Cell membrane
Developmental protein
Disulfide bond
EGF-like domain
G-protein coupled receptor
Glycoprotein
Hydroxylation
Laminin EGF-like domain
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NYQ7	Cadherin family member 11 Epidermal growth factor-like protein 1 Flamingo homolog 1 Multiple epidermal growth factor-like domains protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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2

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GO Term	Evidence Code	PMID
cell-cell adhesion	IBA
serotonergic neuron axon guidance	ISS
dopaminergic neuron axon guidance	ISS
homophilic cell adhesion via plasma membrane adhesion molecules	IEA
Wnt signaling pathway, planar cell polarity pathway	NAS	24431302

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

homophilic cell adhesion via plasma membrane adhesion molecules

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

non-canonical Wnt signaling pathway [inference]

Wnt signaling pathway, planar cell polarity pathway

G protein-coupled receptor signaling pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

non-canonical Wnt signaling pathway [inference]

Wnt signaling pathway, planar cell polarity pathway

G protein-coupled receptor signaling pathway

Displaying **all 2** entries
GO Term	Evidence Code	PMID
membrane	TAS	15203201
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	17474147
calcium ion binding	IEA
G protein-coupled receptor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cadherin EGF LAG seven-pass G-type receptor 3

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 2** entries
Gene Ontology
calcium ion binding
cell surface receptor signaling pathway

Displaying 1 entry
InterPro
GPCR, family 2-like, 7TM

Ortholog

Displaying entries **11 - 20** of 66 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Equus caballus	100063620			HORSE12149
Oryctolagus cuniculus	100349079			RABIT12807
Xenopus tropicalis	100489102		Xenbase:XB-GENE-852799
Sus scrofa	100622195			PIGXX04032
Loxodonta africana	100674516			LOXAF14774
Cavia porcellus	100727255			CAVPO04766
Cricetulus griseus	100766515			CRIGR12471
Otolemur garnettii	100944039			OTOGA02908
Pan paniscus	100974783	9597_0:00117e		PANPA27800
Papio anubis	101015651			PAPAN24975