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coagulation factor XIII A chain

Summary

Gene Symbol

F13A1

Organism

Homo sapiens (human)

External Links

NCBI Gene

2162

PubChem

2162

Alliance of Genome Resources

HGNC:3531

Annotation

Keyword

3D-structure
Acetylation
Acyltransferase
Blood coagulation
Calcium
Cytoplasm
Direct protein sequencing
Disease variant
Glycoprotein
Metal-binding
Reference proteome
Secreted
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
P00488	Protein-glutamine gamma-glutamyltransferase A chain Transglutaminase A chain

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
blood coagulation	TAS	10801785
peptide cross-linking	IDA	27363989
blood coagulation, fibrin clot formation	IDA	27363989
blood coagulation, fibrin clot formation	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, fibrin clot formation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, fibrin clot formation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, fibrin clot formation

macromolecule modification [inference]

protein modification process [inference]

peptide cross-linking

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, fibrin clot formation

multicellular organismal process [inference]

coagulation [inference]

blood coagulation

biological regulation [inference]

regulation of biological quality [inference]

regulation of body fluid levels [inference]

hemostasis [inference]

blood coagulation

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	NAS	12524220
platelet alpha granule lumen	TAS
collagen-containing extracellular matrix	HDA	25037231 28344315 28675934
blood microparticle	HDA	22516433

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

transferase complex

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

platelet alpha granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

platelet alpha granule lumen

blood microparticle

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein-glutamine gamma-glutamyltransferase activity	IDA	27363989
protein-glutamine gamma-glutamyltransferase activity	IBA
protein binding	IPI	32814053
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

protein-glutamine gamma-glutamyltransferase activity

catalytic activity, acting on a protein [inference]

protein-glutamine gamma-glutamyltransferase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Transglutaminase

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 2** entries
Gene Ontology
metal ion binding
protein-glutamine gamma-glutamyltransferase activity

Displaying **all 9** entries
InterPro
Immunoglobulin E-set
Immunoglobulin-like fold
Papain-like cysteine peptidase superfamily
Protein-glutamine gamma-glutamyltransferase, animal
Transglutaminase, C-terminal domain superfamily
Transglutaminase, C-terminal
Transglutaminase, N-terminal
Transglutaminase-like superfamily
Transglutaminase-like

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0111907	thrombophilia due to thrombin defect	Alliance of Genome Resources
DOID:11247	disseminated intravascular coagulation	Alliance of Genome Resources
DOID:2211	factor XIII deficiency	Alliance of Genome Resources
DOID:2349	arteriosclerosis	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:9286	priapism	Alliance of Genome Resources
DOID:9477	pulmonary embolism	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 87 in total

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Species	Gene ID	Orthologous MAtrix
Takifugu rubripes	101071398	TAKRU49397
Felis catus	101080534	FELCA11271
Ovis aries	101108612	SHEEP10716
Gorilla gorilla gorilla	101144333	GORGO36818
Tursiops truncatus	101328523	TURTR09187
Octodon degus	101585939	OCTDE06371
Jaculus jaculus	101606607	JACJA17901
Mustela putorius furo	101671512	MUSPF13000
Heterocephalus glaber	101715346	HETGA04012
Anas platyrhynchos platyrhynchos	101800928	ANAPP08556

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OrthoDB (Group)

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Acknowledgements