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tubulin, beta 3 class III

Summary

Gene Symbol

Tubb3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

22152

PubChem

22152

Alliance of Genome Resources

MGI:107813

Annotation

Keyword

Cell projection
Cytoskeleton
Direct protein sequencing
GTP-binding
Isopeptide bond
Magnesium
Metal-binding
Microtubule
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9ERD7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
microtubule cytoskeleton organization	IBA ISO ISS
mitotic cell cycle	IBA
neuron differentiation	ISO
dorsal root ganglion development	ISO ISS
netrin-activated signaling pathway	IMP	28483977

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization

cell cycle [inference]

mitotic cell cycle

signal transduction [inference]

cell surface receptor signaling pathway [inference]

netrin-activated signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

ganglion development [inference]

dorsal root ganglion development

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

netrin-activated signaling pathway

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GO Term	Evidence Code	PMID
microtubule	IBA IEA ISO
intracellular anatomical structure	IDA	16892058
neuronal cell body	IDA	23284756
dendrite	IDA	24464040
filopodium	IDA	28483977

GO Hierarchy

cellular component

cellular anatomical entity [inference]

site of polarized growth [inference]

growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

neuron projection [inference]

actin-based cell projection [inference]

filopodium

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

cytoskeleton [inference]

microtubule cytoskeleton

cell body [inference]

neuronal cell body

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

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GO Term	Evidence Code	PMID
protein binding	IPI	17389232 19806181 28483977
GTPase activity	IEA
netrin receptor binding	IPI ISO	28483977
metal ion binding	IEA
structural constituent of cytoskeleton	IBA ISO ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

structural molecule activity [inference]

structural constituent of cytoskeleton

binding [inference]

protein binding

signaling receptor binding [inference]

netrin receptor binding

amide binding [inference]

peptide binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tubulin

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
GTP binding
cytoskeleton organization
microtubule cytoskeleton organization
microtubule-based process
nucleotide binding
structural constituent of cytoskeleton

Displaying **all 9** entries
InterPro
Beta tubulin
Tubulin, C-terminal
Tubulin, conserved site
Tubulin/FtsZ, 2-layer sandwich domain
Tubulin/FtsZ, C-terminal
Tubulin/FtsZ, GTPase domain superfamily
Tubulin/FtsZ, GTPase domain
Tubulin/FtsZ-like, C-terminal domain
Tubulin

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0050997	cerebellar ataxia, mental retardation and dysequlibrium syndrome	Alliance of Genome Resources
DOID:0060260	ptosis	Alliance of Genome Resources
DOID:0080143	congenital fibrosis of the extraocular muscles	Alliance of Genome Resources
DOID:0081017	congenital fibrosis of the extraocular muscles 3A	Alliance of Genome Resources
DOID:0090132	complex cortical dysplasia with other brain malformations 7	Alliance of Genome Resources
DOID:0090137	complex cortical dysplasia with other brain malformations 1	Alliance of Genome Resources
DOID:0112227	tubulinopathy	Alliance of Genome Resources
DOID:13934	facial paralysis	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	10381		HGNC:20772	HUMAN30486
Caenorhabditis elegans	175519		WB:WBGene00006537
Caenorhabditis elegans	179680		WB:WBGene00006539
Rattus norvegicus	246118	10116_1:005017	RGD:628595	RATNO14484
Rattus norvegicus	307351	10116_1:004ef6
Xenopus tropicalis	395045		Xenbase:XB-GENE-5886292
Macaca mulatta	699231			MACMU27542
Bos taurus	768070			BOVIN10351
Saccharomyces cerevisiae S288C	850506		SGD:S000001857
Monodelphis domestica	100027632			MONDO03172

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements