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arylsulfatase G

Summary

Gene Symbol

ARSG

Aliases

KIAA1001

Organism

Homo sapiens (human)

External Links

NCBI Gene

22901

HGNC

24102

KEGG Gene ID

hsa:22901

PubChem

22901

Alliance of Genome Resources

HGNC:24102

Annotation

Keyword

Calcium
Disease variant
Disulfide bond
Glycoprotein
Hydrolase
Lysosome
Metal-binding
Reference proteome
Retinitis pigmentosa
Signal
Usher syndrome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96EG1	N-sulfoglucosamine-3-sulfatase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
retina development in camera-type eye	IEA
lysosome organization	IEA
sulfur compound metabolic process	IDA	18283100
homeostasis of number of cells	IEA
gene expression	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

sulfur compound metabolic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process

cellular metabolic process [inference]

sulfur compound metabolic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells

developmental process [inference]

anatomical structure development [inference]

retina development in camera-type eye

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum lumen	TAS
lysosome	IDA	18283100
endoplasmic reticulum	IDA	12461688
extracellular space	IDA	18283100

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

Displaying **all 3** entries
GO Term	Evidence Code	PMID
arylsulfatase activity	IBA IDA IMP TAS	12461688 16174644 18283100 29300381
metal ion binding	IEA
N-sulfoglucosamine-3-sulfatase activity	IDA	22689975

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

sulfuric ester hydrolase activity [inference]

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

arylsulfatase

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
hydrolase activity
sulfuric ester hydrolase activity

Displaying **all 3** entries
InterPro
Alkaline-phosphatase-like, core domain superfamily
Sulfatase, N-terminal
Sulfatase, conserved site

KEGG BRITE Database

Orthology

K12381

Name

arylsulfatase G [EC:3.1.6.-]

References

18283100

Rhea

RHEA:17261

an aryl sulfate + H₂O

H⁺ + sulfate + a phenol

Enzyme

3.1.6.1

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050439	Usher syndrome	Alliance of Genome Resources
DOID:12798	mucopolysaccharidosis	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 24 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000375	Abnormal cochlea morphology
HP:0000407	Sensorineural hearing impairment
HP:0000408	Progressive sensorineural hearing impairment
HP:0000483	Astigmatism
HP:0000512	Abnormal electroretinogram
HP:0000518	Cataract
HP:0000546	Retinal degeneration
HP:0000572	Visual loss
HP:0000575	Scotoma

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:618144	Usher syndrome, type 4
ORPHA:231183	Usher syndrome type 3 retinitis pigmentosa-deafness syndrome

PubChem Disease

MedGen Diseases

Usher syndrome, type 4

OMIM Phenotypes

USHER SYNDROME, TYPE IV; USH4

KEGG Diseases

Usher syndrome

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP005434
Gene Name: arylsulfatase G

Ortholog

Displaying entries **11 - 20** of 81 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Oryctolagus cuniculus	100340274		RABIT07905
Callithrix jacchus	100400154		CALJA35313
Pongo abelii	100447099	9601_0:0044f1	PONAB11917
Ailuropoda melanoleuca	100475746		AILME06185
Meleagris gallopavo	100546213		MELGA06723
Anolis carolinensis	100555681		ANOCA16215
Nomascus leucogenys	100596795		NOMLE08157
Loxodonta africana	100663356		LOXAF07292
Oreochromis niloticus	100711085		ORENI73012
Cavia porcellus	100716143		CAVPO19580

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements