GlyCosmos Portal

Submissions

SREBF chaperone

Summary

Gene Symbol

SCAP

Organism

Homo sapiens (human)

External Links

NCBI Gene

22937

PubChem

22937

Alliance of Genome Resources

HGNC:30634

Annotation

Keyword

3D-structure
Alternative splicing
Cholesterol metabolism
Cytoplasmic vesicle
Endoplasmic reticulum
Glycoprotein
Golgi apparatus
Isopeptide bond
Lipid-binding
Methylation
Phosphoprotein
Reference proteome
Repeat
Transmembrane helix
Ubl conjugation
WD repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B7Z6H0
Q12770

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
cholesterol metabolic process	ISS
response to vitamin B3	IEA
positive regulation of cholesterol biosynthetic process	IDA	32322062
regulation of cholesterol biosynthetic process	IBA
negative regulation of cholesterol biosynthetic process	NAS

GO Hierarchy

biological process

immune system process [inference]

immune response

metabolic process [inference]

cellular metabolic process [inference]

cellular lipid metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

cellular lipid metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

cellular lipid metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

signal transduction [inference]

ER-nucleus signaling pathway [inference]

SREBP signaling pathway

cellular metabolic process [inference]

cellular lipid metabolic process

cellular localization [inference]

intracellular transport [inference]

COPII-coated vesicle cargo loading

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to sterol depletion [inference]

SREBP signaling pathway

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to sterol depletion [inference]

cellular response to sterol depletion [inference]

SREBP signaling pathway

cellular response to stress [inference]

cellular response to sterol depletion [inference]

SREBP signaling pathway

immune response

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin B3

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin B3

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to sterol depletion [inference]

SREBP signaling pathway

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle cargo loading [inference]

COPII-coated vesicle cargo loading

intracellular transport [inference]

COPII-coated vesicle cargo loading

establishment of localization in cell [inference]

intracellular transport [inference]

COPII-coated vesicle cargo loading

cellular localization [inference]

intracellular transport [inference]

COPII-coated vesicle cargo loading

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of fatty acid biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of fatty acid biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of steroid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of small molecule metabolic process [inference]

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of fatty acid biosynthetic process

regulation of small molecule metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

negative regulation of small molecule metabolic process [inference]

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid biosynthetic process

regulation of steroid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of steroid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of fatty acid biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of steroid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of small molecule metabolic process [inference]

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of cellular process [inference]

signal transduction [inference]

ER-nucleus signaling pathway [inference]

SREBP signaling pathway

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of fatty acid biosynthetic process

Displaying entries **1 - 5** of 7 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
membrane	NAS	11726962
Golgi apparatus	NAS	11726962
endoplasmic reticulum membrane	IBA IDA	32111832
SREBP-SCAP complex	IBA
Golgi membrane	IDA TAS	32111832

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

SREBP-SCAP complex

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

ER to Golgi transport vesicle membrane

coated vesicle membrane [inference]

ER to Golgi transport vesicle membrane

bounding membrane of organelle [inference]

Golgi membrane

transport vesicle membrane [inference]

ER to Golgi transport vesicle membrane

coated vesicle membrane [inference]

ER to Golgi transport vesicle membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	17428920 19706601 32111832
protein-containing complex binding	IEA
sterol binding	ISS
unfolded protein binding	NAS	11726962

GO Hierarchy

molecular function

binding [inference]

protein binding

unfolded protein binding

lipid binding [inference]

steroid binding [inference]

sterol binding

protein-containing complex binding

organic cyclic compound binding [inference]

steroid binding [inference]

sterol binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sterol regulatory element-binding cleavage-activating

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
proteasome-mediated ubiquitin-dependent protein catabolic process
protein polyubiquitination
transcription-coupled nucleotide-excision repair

Displaying **all 5** entries
InterPro
DNA excision repair protein Rad28/ERCC8/Ckn1/ATCSA-1
WD40 repeat, conserved site
WD40 repeat
WD40-repeat-containing domain superfamily
WD40/YVTN repeat-like-containing domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:783	end stage renal disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 85 in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	35529		FB:FBgn0033052
Caenorhabditis elegans	174479		WB:WBGene00004744
Mus musculus	235623		MGI:2135958	MOUSE63393
Rattus norvegicus	301024		RGD:1309378	RATNO41585
Xenopus laevis	443598		Xenbase:XB-GENE-996524
Pan troglodytes	460334	9598_0:00117c		PANTR30999
Canis lupus familiaris	484782			CANLF07552
Bos taurus	507878			BOVIN17930
Danio rerio	558292		ZFIN:ZDB-GENE-040107-41	DANRE11188
Macaca mulatta	711528			MACMU28675

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements