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phospholipase C beta 1
Summary
- Gene Symbol
-
- PLCB1
- Aliases
-
- KIAA0581
- PLC-I
- PLC154
- phosphoinositide phospholipase C
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Alternative splicing
- Calcium
- Cytoplasm
- Epilepsy
- Hydrolase
- Lipid degradation
- Membrane
- Nucleus
- Palmitate
- Phosphoprotein
- Reference proteome
- Transducer
- Proteins
| UniProt | Protein Name |
|---|---|
| Q9NQ66 |
|
Gene Ontology (GO)
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of localization [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
signal transduction
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cell cycle [inference]
regulation of cell motility [inference]
regulation of multicellular organismal process [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| enzyme binding | ||
| phospholipase C activity |
|
|
| phosphatidylinositol-4,5-bisphosphate binding | ||
| calcium ion binding | ||
| lamin binding |
GO Hierarchy
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:657 | adenoma | |
| DOID:6726 | fibrillary astrocytoma | |
| DOID:6811 | juvenile pilocytic astrocytoma | |
| DOID:684 | hepatocellular carcinoma | |
| DOID:7005 | gemistocytic astrocytoma | |
| DOID:7007 | childhood cerebral astrocytoma | |
| DOID:7008 | protoplasmic astrocytoma | |
| DOID:769 | neuroblastoma | |
| DOID:7912 | mixed oligodendroglioma-astrocytoma | |
| DOID:9119 | acute myeloid leukemia |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0004302 | Functional motor deficit |
| HP:0006813 | Focal hemiclonic seizure |
| HP:0007334 | Bilateral tonic-clonic seizure with focal onset |
| HP:0007359 | Focal-onset seizure |
| HP:0008936 | Axial hypotonia |
| HP:0010821 | Focal emotional seizure with laughing |
| HP:0010841 | Multifocal epileptiform discharges |
| HP:0011097 | Epileptic spasm |
| HP:0011121 | Abnormal skin morphology |
| HP:0012448 | Delayed myelination |
| Disease ID | Disease Name |
|---|---|
| ORPHA:293181 |
|
| OMIM:613722 |
|
| ORPHA:3451 |
|
PubChem Disease
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP000936
- Gene Name
- phospholipase C, beta 1 (phosphoinositide-specific)
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 100481755 | AILME10778 | ||
| 101678347 | MUSPF13915 | ||
| 101092262 | FELCA06421 | ||
| 122215803 | PANLE01136 | ||
| 118881571 | BALMU20704 | ||
| 100051558 | HORSE21214 | ||
| 100152679 | PIGXX11241 | ||
| 287026 | BOVIN04202 | ||
| 102188148 | CAPHI03220 | ||
| 101103585 | SHEEP04084 |
