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solute carrier family 37 member 4

Summary

Gene Symbol

SLC37A4

Aliases

G6PT
GSD1b
GSD1c
GSD1d
Glucose-6-phosphate exchanger SLC37A4
SPX4
glucose-6-phosphatase transporter
sugar-phosphate exchange protein 4

Organism

Homo sapiens (human)

External Links

NCBI Gene

2542

HGNC

4061

KEGG Gene ID

hsa:2542

PubChem

2542

Alliance of Genome Resources

HGNC:4061

Annotation

Keyword

Alternative splicing
Antiport
Congenital disorder of glycosylation
Disease variant
Endoplasmic reticulum
Glycogen storage disease
Reference proteome
Sugar transport
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
O43826	Glucose-5-phosphate transporter Glucose-6-phosphate translocase Solute carrier family 37 member 4 Transformation-related gene 19 protein
B4DUH2
A8K0S7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
phosphate ion transmembrane transport	IBA IDA	21949678
glucose metabolic process	NAS	9428641
glucose homeostasis
glucose-6-phosphate transport	IBA IDA IMP NAS	10026167 12560945 21949678 33964207 9428641
gluconeogenesis	TAS

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular process [inference]

transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

phosphate ion transmembrane transport

homeostatic process [inference]

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

inorganic anion transport [inference]

phosphate ion transport [inference]

phosphate ion transmembrane transport

inorganic anion transmembrane transport [inference]

phosphate ion transmembrane transport

transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

phosphate ion transmembrane transport

organic substance transport [inference]

organophosphate ester transport [inference]

hexose phosphate transport [inference]

glucose-6-phosphate transport

carbohydrate derivative transport [inference]

hexose phosphate transport [inference]

glucose-6-phosphate transport

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	NAS	212064
endoplasmic reticulum membrane	IBA IDA TAS	21949678 33964207
plasma membrane
membrane	HDA NAS	19946888 9428641

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 3** entries
GO Term	Evidence Code	PMID
glucose-6-phosphate transmembrane transporter activity	IMP	12560945
glucose 6-phosphate:inorganic phosphate antiporter activity	EXP IBA IDA TAS	18337460 21949678
protein binding	IPI	32296183

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

solute:inorganic anion antiporter activity [inference]

organophosphate:inorganic phosphate antiporter activity [inference]

hexose-phosphate:inorganic phosphate antiporter activity [inference]

glucose 6-phosphate:inorganic phosphate antiporter activity

phosphate ion transmembrane transporter activity [inference]

organophosphate:inorganic phosphate antiporter activity [inference]

hexose-phosphate:inorganic phosphate antiporter activity [inference]

glucose 6-phosphate:inorganic phosphate antiporter activity

organophosphate ester transmembrane transporter activity [inference]

hexose phosphate transmembrane transporter activity [inference]

glucose-6-phosphate transmembrane transporter activity

glucose 6-phosphate:inorganic phosphate antiporter activity

hexose-phosphate:inorganic phosphate antiporter activity [inference]

glucose 6-phosphate:inorganic phosphate antiporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity [inference]

solute:inorganic anion antiporter activity [inference]

organophosphate:inorganic phosphate antiporter activity [inference]

hexose-phosphate:inorganic phosphate antiporter activity [inference]

glucose 6-phosphate:inorganic phosphate antiporter activity

carbohydrate derivative transmembrane transporter activity [inference]

hexose phosphate transmembrane transporter activity [inference]

glucose-6-phosphate transmembrane transporter activity

glucose 6-phosphate:inorganic phosphate antiporter activity

hexose-phosphate:inorganic phosphate antiporter activity [inference]

glucose 6-phosphate:inorganic phosphate antiporter activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000137700

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K08171

Name

MFS transporter, OPA family, solute carrier family 37 (glycerol-6-phosphate transporter), member 4

References

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:12987	agranulocytosis	DisGeNET DisGeNET
DOID:1312	focal segmental glomerulosclerosis	DisGeNET
DOID:13189	gout	DisGeNET
DOID:1319	brain cancer	DisGeNET
DOID:13579	kwashiorkor	DisGeNET
DOID:1425	pyoureter	DisGeNET
DOID:14557	primary pulmonary hypertension	DisGeNET
DOID:162	cancer	DisGeNET DisGeNET DisGeNET
DOID:1837	diabetic ketoacidosis	DisGeNET DisGeNET
DOID:1920	hyperuricemia	DisGeNET

The Human Phenotype Ontology

Displaying entries **101 - 110** of **135** in total

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HPO ID	HPO Term
HP:0004387	Enterocolitis
HP:0004502	Bilateral choanal atresia
HP:0004841	Reduced factor XII activity
HP:0005576	Tubulointerstitial fibrosis
HP:0006280	Chronic pancreatitis
HP:0006568	Increased hepatic glycogen content
HP:0006579	Prolonged neonatal jaundice
HP:0008151	Prolonged prothrombin time
HP:0008169	Reduced factor VII activity
HP:0008357	Reduced factor XIII activity

Displaying **all 4** entries
Disease ID	Disease Name
OMIM:232240	glycogen storage disease Ib
OMIM:619525	congenital disorder of glycosylation, type IIw
ORPHA:79259	glycogen storage disease Ib
OMIM:232220	glycogen storage disease Ib

PubChem Disease

GHR Health Conditions

Glycogen storage disease type I

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

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Species	Gene ID	Orthologous MAtrix
Hippocampus comes	109509771	HIPCM27687
Echeneis naucrates	115053230	ECHNA06463
Salarias fasciatus	115401021	SALFA47125
Propithecus coquereli	105819236	PROCO27901
Cyprinus carpio carpio	109048434	CYPCA113707
Cyprinus carpio carpio	109103807	CYPCA93448
Nannospalax galili	103727883	NANGA06572
Corvus moneduloides	116455635	CORMO12368
Carlito syrichta	103270711	CARSF11830
Strigops habroptila	115616416	STRHB18160

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GlycoPOST

UniCarb-DR

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Other Information

Tools

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Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements