U.S. flag

An official website of the United States government

Kcnb1 potassium voltage-gated channel subfamily B member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25736, updated on 9-Dec-2024

Summary

Official Symbol
Kcnb1provided by RGD
Official Full Name
potassium voltage-gated channel subfamily B member 1provided by RGD
Primary source
RGD:2954
See related
EnsemblRapid:ENSRNOG00000046949 AllianceGenome:RGD:2954
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Shab; Kv2.1; DRK1PC; Kcr1-1
Summary
Enables several functions, including protein heterodimerization activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Involved in several processes, including clustering of voltage-gated potassium channels; positive regulation of secretion by cell; and potassium ion export across plasma membrane. Acts upstream of or within potassium ion transport. Located in several cellular components, including dendrite; lateral plasma membrane; and neuronal cell body membrane. Part of voltage-gated potassium channel complex. Is active in cholinergic synapse and postsynaptic specialization membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 26 and epilepsy. Orthologous to human KCNB1 (potassium voltage-gated channel subfamily B member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Brain (RPKM 97.7), Heart (RPKM 71.3) and 6 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Kcnb1 in Genome Data Viewer
Location:
3q42
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (176239285..176332408, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (155820255..155913383, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (163850785..163935610, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100911177 Neighboring gene small nucleolar SNORD12/SNORD106 Neighboring gene small nucleolar RNA, C/D box 12 Neighboring gene prostaglandin I2 synthase Neighboring gene ribosomal protein L38, pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Items 1 - 25 of 44
Process Evidence Code Pubs
involved_in action potential  
involved_in action potential PubMed 
involved_in action potential  
involved_in action potential  
involved_in action potential  
involved_in cellular response to calcium ion PubMed 
involved_in cellular response to glucose stimulus  
involved_in cellular response to glucose stimulus  
involved_in cellular response to glucose stimulus  
involved_in cellular response to nutrient levels PubMed 
involved_in clustering of voltage-gated potassium channels PubMed 
involved_in exocytosis  
involved_in glucose homeostasis  
involved_in glucose homeostasis  
involved_in glutamate receptor signaling pathway PubMed 
involved_in negative regulation of insulin secretion  
involved_in negative regulation of insulin secretion  
involved_in negative regulation of insulin secretion  
involved_in positive regulation of calcium ion-dependent exocytosis PubMed 
involved_in positive regulation of catecholamine secretion PubMed 
involved_in positive regulation of long-term synaptic depression  
involved_in positive regulation of long-term synaptic depression  
involved_in positive regulation of long-term synaptic depression  
involved_in positive regulation of norepinephrine secretion PubMed 
involved_in positive regulation of protein targeting to membrane PubMed 
involved_in positive regulation of protein targeting to membrane  
involved_in positive regulation of protein targeting to membrane  
involved_in potassium ion export across plasma membrane PubMed 
involved_in potassium ion transmembrane transport  
involved_in potassium ion transmembrane transport PubMed 
involved_in potassium ion transmembrane transport  
involved_in potassium ion transmembrane transport  
acts_upstream_of_or_within potassium ion transport PubMed 
involved_in potassium ion transport PubMed 
involved_in potassium ion transport PubMed 
involved_in protein homooligomerization  
involved_in protein localization to plasma membrane PubMed 
involved_in regulation of action potential  
involved_in regulation of action potential  
involved_in regulation of action potential  
involved_in regulation of motor neuron apoptotic process PubMed 
involved_in response to L-glutamate PubMed 
involved_in response to axon injury PubMed 
involved_in vesicle docking involved in exocytosis PubMed 
Items 1 - 25 of 44
Items 1 - 20 of 33
Component Evidence Code Pubs
located_in apical plasma membrane PubMed 
is_active_in axon  
located_in axon PubMed 
located_in axon  
located_in cell surface PubMed 
is_active_in cholinergic synapse PubMed 
located_in dendrite PubMed 
located_in dendrite  
located_in dendrite  
is_active_in dendrite membrane  
located_in dendrite membrane PubMed 
located_in lateral plasma membrane PubMed 
located_in lateral plasma membrane  
located_in neuronal cell body PubMed 
is_active_in neuronal cell body membrane  
located_in neuronal cell body membrane PubMed 
located_in neuronal cell body membrane  
located_in neuronal cell body membrane  
located_in perikaryon PubMed 
located_in perikaryon  
located_in perinuclear region of cytoplasm PubMed 
located_in plasma membrane PubMed 
located_in plasma membrane  
is_active_in postsynaptic membrane  
located_in postsynaptic membrane PubMed 
located_in postsynaptic membrane  
is_active_in postsynaptic specialization membrane PubMed 
located_in proximal dendrite PubMed 
located_in sarcolemma  
part_of voltage-gated potassium channel complex  
part_of voltage-gated potassium channel complex PubMed 
part_of voltage-gated potassium channel complex  
part_of voltage-gated potassium channel complex  
Items 1 - 20 of 33

General protein information

Preferred Names
potassium voltage-gated channel subfamily B member 1
Names
DRK1
delayed rectifier potassium channel 1
potassium channel Kv2.1
potassium channel, voltage gated Shab-related subfamily B, member 1
potassium voltage gated channel, Shab-related subfamily, member 1
voltage-gated potassium channel subunit Kv2.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013186.3NP_037318.2  potassium voltage-gated channel subfamily B member 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    P15387
    UniProtKB/TrEMBL
    A0A0H2UI34, A6JXI9
    Related
    ENSRNOP00000065961.3, ENSRNOT00000074023.4
    Conserved Domains (3) summary
    cd18412
    Location:15141
    BTB_POZ_KCNB2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 2 (KCNB2)
    pfam00520
    Location:188424
    Ion_trans; Ion transport protein
    pfam03521
    Location:467678
    Kv2channel; Kv2 voltage-gated K+ channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    176239285..176332408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_010064569.1 RNA Sequence

External link. Please review our privacy policy.