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TTL family tubulin polyglutamylase complex subunit L1

Summary

Gene Symbol

TTLL1

Organism

Homo sapiens (human)

External Links

NCBI Gene

25809

PubChem

25809

Alliance of Genome Resources

HGNC:1312

JoGo

TTLL1

TogoVar

TTLL1

Annotation

Keyword

ATP-binding
Alternative splicing
Cytoskeleton
Flagellum
Ligase
Magnesium
Metal-binding
Microtubule
Proteomics identification
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
O95922	Tubulin polyglutamylase TTLL1 Tubulin polyglutamylase complex subunit 3 Tubulin--tyrosine ligase-like protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
microtubule cytoskeleton organization	IDA	34782749
immune response in nasopharyngeal-associated lymphoid tissue	IEA
sperm axoneme assembly	IBA
protein polyglutamylation	TAS	15890843
cerebellar Purkinje cell differentiation	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

immune response in gut-associated lymphoid tissue [inference]

immune response in nasopharyngeal-associated lymphoid tissue

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein polyglutamylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein polyglutamylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein polyglutamylation

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein polyglutamylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein polyglutamylation

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization

microtubule bundle formation [inference]

axoneme assembly [inference]

sperm axoneme assembly

microtubule-based movement [inference]

cilium movement [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

mucociliary clearance

cellular process involved in reproduction in multicellular organism [inference]

sperm axoneme assembly

cellular developmental process [inference]

cell differentiation [inference]

cell differentiation in hindbrain [inference]

cerebellar Purkinje cell differentiation

neuron differentiation [inference]

central nervous system neuron differentiation [inference]

cerebellar Purkinje cell differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization

microtubule bundle formation [inference]

axoneme assembly [inference]

sperm axoneme assembly

cellular component assembly [inference]

axoneme assembly [inference]

sperm axoneme assembly

reproductive process [inference]

developmental process involved in reproduction [inference]

sperm axoneme assembly

cellular process involved in reproduction in multicellular organism [inference]

sperm axoneme assembly

multicellular organismal process [inference]

system process [inference]

respiratory system process [inference]

mucociliary clearance

developmental process [inference]

developmental process involved in reproduction [inference]

sperm axoneme assembly

cellular developmental process [inference]

cell differentiation [inference]

cell differentiation in hindbrain [inference]

cerebellar Purkinje cell differentiation

neuron differentiation [inference]

central nervous system neuron differentiation [inference]

cerebellar Purkinje cell differentiation

response to stimulus [inference]

immune response [inference]

immune response in gut-associated lymphoid tissue [inference]

immune response in nasopharyngeal-associated lymphoid tissue

localization [inference]

establishment of localization [inference]

transport [inference]

extracellular transport [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

mucociliary clearance

microtubule-based transport [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

mucociliary clearance

biological regulation [inference]

regulation of biological process [inference]

regulation of developmental process [inference]

regulation of blastocyst development

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular region	IEA
cytoplasm	IEA
microtubule	IDA	34782749
motile cilium	IEA
ciliary basal body	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

ciliary basal body

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

motile cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

motile cilium

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
ATP binding	IEA
tubulin binding	IBA
metal ion binding	IEA
tubulin-glutamic acid ligase activity	TAS	15890843
tubulin-glutamic acid ligase activity	IDA	34782749

GO Hierarchy

molecular function

catalytic activity [inference]

ligase activity [inference]

ligase activity, forming carbon-nitrogen bonds [inference]

acid-amino acid ligase activity [inference]

protein-glutamic acid ligase activity [inference]

catalytic activity, acting on a protein [inference]

protein-glutamic acid ligase activity [inference]

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

tubulin binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tubulin--tyrosine ligase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
microtubule cytoskeleton organization
nucleotide binding
tubulin binding
tubulin-glutamic acid ligase activity

Displaying 1 entry
InterPro
Tubulin-tyrosine ligase/Tubulin polyglutamylase

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026

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