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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
glutamate-cysteine ligase catalytic subunit
Summary
- Gene Symbol
-
- GCLC
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- ATP-binding
- Acetylation
- Disease variant
- Glutathione biosynthesis
- Hereditary hemolytic anemia
- Ligase
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| cellular response to fibroblast growth factor stimulus | ||
| cellular response to mechanical stimulus | ||
| response to arsenic-containing substance | ||
| negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | ||
| cell redox homeostasis |
GO Hierarchy
- response to activity
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
response to endogenous stimulus [inference]
response to chemical [inference]
cellular response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of catabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| glutamate-cysteine ligase complex | ||
| mitochondrion | ||
| cytosol |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| glutamate-cysteine ligase activity | ||
| protein-containing complex binding | ||
| glutamate binding | ||
| magnesium ion binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- glutamate cysteine ligase
- Functional Category
-
- E: Amino acid transport and metabolism
- J: Translation, ribosomal structure and biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| catalytic activity |
| glutamate-cysteine ligase activity |
| glutathione biosynthetic process |
| ligase activity |
| nucleotide binding |
| InterPro |
|---|
| Glutamate-cysteine ligase catalytic subunit |
| Glutamine synthetase/guanido kinase, catalytic domain |
Disease
- Disease Ontology
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 117017146 | RHIFE11301 | |||
| 118283257 | SCOMX08184 | |||
| 118903717 | BALMU25901 | |||
| 122220033 | PANLE15687 | |||
| 129039630 | 9600_0:001a73 |
