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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
glycine decarboxylase
Summary
- Gene Symbol
-
- GLDC
- Aliases
-
- GCSP
- NKH
- glycine cleavage system protein P
- glycine dehydrogenase
- nonketotic hyperglycinemia
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Disease variant
- Mitochondrion
- Oxidoreductase
- Pyridoxal phosphate
- Reference proteome
- Transit peptide
- Proteins
| UniProt | Protein Name |
|---|---|
| P23378 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| glycine decarboxylation via glycine cleavage system | ||
| glycine catabolic process | ||
| response to methylamine | ||
| cellular response to leukemia inhibitory factor | ||
| response to lipoic acid |
GO Hierarchy
biological process
metabolic process [inference]
nitrogen compound metabolic process [inference]
catabolic process [inference]
cellular metabolic process [inference]
small molecule metabolic process [inference]
organic substance metabolic process [inference]
cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| glycine cleavage complex | ||
| plasma membrane | ||
| mitochondrial matrix |
|
|
| mitochondrion | ||
| nucleoplasm |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| electron transfer activity |
|
|
| lyase activity | ||
| protein homodimerization activity | ||
| pyridoxal phosphate binding | ||
| pyridoxal binding |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0014667 | disease of metabolism | |
| DOID:0050569 | Seckel syndrome | |
| DOID:0050841 | focal hand dystonia | |
| DOID:0060254 | Robinow syndrome | |
| DOID:0060578 | Noonan syndrome 1 | |
| DOID:0060580 | Noonan syndrome 2 | |
| DOID:0060581 | Noonan syndrome 3 | |
| DOID:0060582 | Noonan syndrome 4 | |
| DOID:0060583 | Noonan syndrome 5 | |
| DOID:0060584 | Noonan syndrome 6 |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0001274 | Agenesis of corpus callosum |
| HP:0001290 | Generalized hypotonia |
| HP:0001298 | Encephalopathy |
| HP:0001336 | Myoclonus |
| HP:0001347 | Hyperreflexia |
| HP:0001522 | Death in infancy |
| HP:0002154 | Hyperglycinemia |
| HP:0003108 | Hyperglycinuria |
| HP:0100247 | Recurrent singultus |
| HP:0100710 | Impulsivity |
| Disease ID | Disease Name |
|---|---|
| OMIM:605899 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 113490365 | ATHCN19972 | ||
| 105812850 | PROCO22320 | ||
| 855227 | SGD:S000004801 | ||
| 109062881 | CYPCA13776 | ||
| 109110447 | CYPCA17425 | ||
| 103732512 | NANGA15522 | ||
| 116438367 | CORMO28412 | ||
| 115619405 | STRHB08303 |
