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mono-ADP ribosylhydrolase 1

Summary

Gene Symbol

MACROD1

Aliases

LRP16

Organism

Homo sapiens (human)

External Links

NCBI Gene

28992

HGNC

29598

PubChem

28992

Alliance of Genome Resources

HGNC:29598

Annotation

Keyword

3D-structure
Acetylation
Chromosomal rearrangement
DNA damage
Hydrolase
Isopeptide bond
Nucleus
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9BQ69	MACRO domain-containing protein 1 O-acetyl-ADP-ribose deacetylase MACROD1 Protein LRP16 [Protein ADP-ribosylaspartate] hydrolase MACROD1 [Protein ADP-ribosylglutamate] hydrolase MACROD1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
purine nucleoside metabolic process	IBA IDA	21257746
peptidyl-glutamate ADP-deribosylation	IBA IDA	23474714
cellular response to DNA damage stimulus	IBA IMP	23474712
protein de-ADP-ribosylation	IDA	23474712
DNA damage response	IBA IMP	23474712

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

organonitrogen compound metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

macromolecule modification [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

carbohydrate derivative metabolic process [inference]

glycosyl compound metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

organonitrogen compound metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response

Displaying **all 2** entries
GO Term	Evidence Code	PMID
nucleus	IDA	23474712
nucleoplasm	IBA IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
hydrolase activity, acting on glycosyl bonds	IDA	23474712
ADP-ribosylglutamate hydrolase activity	IBA IDA	23474714
protein binding	IPI	17914104 20035625 21483817 32296183
deacetylase activity	IDA	21257746

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

ADP-ribosylglutamate hydrolase activity

deacetylase activity

catalytic activity, acting on a protein [inference]

ADP-ribosylglutamate hydrolase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Rhea

RHEA:59244

3''-O-acetyl-ADP-D-ribose + H₂O

H⁺ + acetate + ADP-D-ribose

Enzyme

3.1.1.106

PMID

RHEA:57060

H₂O + 2''-O-acetyl-ADP-D-ribose

H⁺ + acetate + ADP-D-ribose

Enzyme

3.1.1.106

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 29 in total

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DO ID	Disease Name	Source
DOID:0014667	disease of metabolism	DisGeNET
DOID:0050742	nicotine dependence	DisGeNET
DOID:0060597	atypical chronic myeloid leukemia, BCR-ABL1 negative	DisGeNET
DOID:0080199	colorectal carcinoma	DisGeNET
DOID:1037	lymphoid leukemia	DisGeNET
DOID:114	heart disease	DisGeNET
DOID:1240	leukemia	DisGeNET
DOID:1287	cardiovascular system disease	DisGeNET
DOID:13189	gout	DisGeNET DisGeNET
DOID:1380	endometrial cancer	DisGeNET DisGeNET

Ortholog

Displaying entries **21 - 30** of 44 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Balaenoptera musculus	118899171		BALMU09479
Equus caballus	102149144		HORSE05152
Sus scrofa	100522538		PIGXX16905
Bos taurus	613568		BOVIN23363
Capra hircus	100861314		CAPHI19427
Dipodomys ordii	105989116		DIPOR16844
Mus musculus	107227	MGI:2147583	MOUSE25620
Rattus norvegicus	246233	RGD:628701	RATNO19359
Cavia porcellus	100732197		CAVPO15704
Octodon degus	101564929		OCTDE22326

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