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Ppie peptidylprolyl isomerase E [ Rattus norvegicus (Norway rat) ]

Gene ID: 298508, updated on 9-Dec-2024

Summary

Official Symbol
Ppieprovided by RGD
Official Full Name
peptidylprolyl isomerase Eprovided by RGD
Primary source
RGD:1311411
See related
EnsemblRapid:ENSRNOG00000014762 AllianceGenome:RGD:1311411
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ab1-210
Summary
Predicted to enable RNA binding activity; cyclosporin A binding activity; and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in gene expression; positive regulation of viral genome replication; and regulation of DNA-templated transcription. Predicted to be located in cytosol and nuclear speck. Predicted to be part of U2-type catalytic step 2 spliceosome. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Orthologous to human PPIE (peptidylprolyl isomerase E). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Thymus (RPKM 107.1), Spleen (RPKM 80.8) and 9 other tissues See more
Orthologs
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Genomic context

See Ppie in Genome Data Viewer
Location:
5q36
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (140691285..140704347, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (135406172..135419332, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (140822141..140835244, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene tRNA isopentenyltransferase 1 Neighboring gene bone morphogenetic protein 8b Neighboring gene 3-oxoacid CoA transferase 2B Neighboring gene uncharacterized LOC134486987 Neighboring gene uncharacterized LOC120102973 Neighboring gene hippocalcin-like 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity  
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity  
enables cyclosporin A binding  
enables mRNA binding  
enables peptidyl-prolyl cis-trans isomerase activity  
enables peptidyl-prolyl cis-trans isomerase activity  
enables poly(A) binding  
Component Evidence Code Pubs
part_of U2-type catalytic step 2 spliceosome  
part_of catalytic step 2 spliceosome  
part_of catalytic step 2 spliceosome  
is_active_in cytoplasm  
located_in cytosol  
located_in cytosol  
is_active_in intracellular membrane-bounded organelle  
located_in nuclear speck  
located_in nuclear speck  
located_in nucleus  

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase E
Names
peptidylprolyl isomerase E (cyclophilin E)
NP_001382655.1
NP_001382656.1
XP_017448769.1
XP_038965539.1
XP_038965540.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395726.1NP_001382655.1  peptidyl-prolyl cis-trans isomerase E isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I6ADY2, B0BMU0
    Related
    ENSRNOP00000091565.2, ENSRNOT00000101946.2
    Conserved Domains (2) summary
    cd01926
    Location:140298
    cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...
    cd12347
    Location:882
    RRM_PPIE; RNA recognition motif (RRM) found in cyclophilin-33 (Cyp33) and similar proteins
  2. NM_001395727.1NP_001382656.1  peptidyl-prolyl cis-trans isomerase E isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I6ADY2
    Conserved Domains (2) summary
    cd01926
    Location:74232
    cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...
    cl17169
    Location:116
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    140691285..140704347 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109612.2XP_038965540.1  peptidyl-prolyl cis-trans isomerase E isoform X2

    UniProtKB/TrEMBL
    A0A8I6ADY2
    Conserved Domains (2) summary
    cd01926
    Location:74232
    cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...
    cl17169
    Location:116
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. XM_017593280.3XP_017448769.1  peptidyl-prolyl cis-trans isomerase E isoform X3

    Conserved Domains (1) summary
    cd01926
    Location:56214
    cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...
  3. XM_039109611.2XP_038965539.1  peptidyl-prolyl cis-trans isomerase E isoform X1

    UniProtKB/TrEMBL
    A0A8I6ADY2
    Conserved Domains (2) summary
    cd01926
    Location:96254
    cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...
    cl17169
    Location:2338
    RRM_SF; RNA recognition motif (RRM) superfamily

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