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glycogen synthase 2

Summary

Gene Symbol

GYS2

Organism

Homo sapiens (human)

External Links

NCBI Gene

2998

HGNC

4707

KEGG Gene ID

hsa:2998

PubChem

2998

Alliance of Genome Resources

HGNC:4707

Annotation

Keyword

Allosteric enzyme
Disease variant
Glycogen biosynthesis
Glycogen storage disease
Glycosyltransferase
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P54840	Glycogen synthase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
glycogen biosynthetic process	IBA IDA IEA IMP ISS TAS	1731614 9691087
response to glucose	ISS

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process [inference]

glycogen biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

glucan metabolic process [inference]

glycogen metabolic process [inference]

glycogen biosynthetic process

glucan biosynthetic process [inference]

glycogen biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

glucan metabolic process [inference]

glycogen metabolic process [inference]

glycogen biosynthetic process

glucan biosynthetic process [inference]

glycogen biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

glucan metabolic process [inference]

glycogen metabolic process [inference]

glycogen biosynthetic process

glucan biosynthetic process [inference]

glycogen biosynthetic process

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process [inference]

glycogen biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cortical actin cytoskeleton	ISS
cytoskeleton	ISS
cytosol	ISS TAS
cytoplasm	IBA ISS
cell cortex	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell cortex

cytosol

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cortical cytoskeleton [inference]

cortical actin cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cortical cytoskeleton [inference]

cortical actin cytoskeleton

Displaying **all 2** entries
GO Term	Evidence Code	PMID
glycogen (starch) synthase activity	EXP IBA IDA IMP ISS	1731614 9691087
glycogen synthase activity, transferring glucose-1-phosphate	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

UDP-glucosyltransferase activity [inference]

glycogen (starch) synthase activity

hexosyltransferase activity [inference]

glucosyltransferase activity [inference]

UDP-glucosyltransferase activity [inference]

glycogen (starch) synthase activity

transferase activity, transferring phosphorus-containing groups [inference]

glycogen synthase activity, transferring glucose-1-phosphate

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000111713

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00693

Name

glycogen synthase [EC:2.4.1.11]

References

Rhea

UDP-α-D-glucose

H⁺ + UDP

Enzyme

2.4.1.11

PMID

Disease

Disease Ontology

Displaying entries **31 - 40** of 48 in total

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DO ID	Disease Name	Source
DOID:2907	Goldenhar syndrome	DisGeNET
DOID:3534	Lafora disease	Alliance of Genome Resources
DOID:3571	liver cancer	DisGeNET
DOID:3861	medullomyoblastoma	DisGeNET DisGeNET DisGeNET
DOID:3864	adult medulloblastoma	DisGeNET DisGeNET DisGeNET
DOID:3868	melanotic medulloblastoma	DisGeNET DisGeNET DisGeNET
DOID:3869	childhood medulloblastoma	DisGeNET DisGeNET DisGeNET
DOID:4195	hyperglycemia	DisGeNET DisGeNET
DOID:4249	Gerstmann-Straussler-Scheinker syndrome	DisGeNET
DOID:4258	Weissenbacher-Zweymuller syndrome	DisGeNET

The Human Phenotype Ontology

Displaying entries **11 - 18** of 18 in total

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HPO ID	HPO Term
HP:0002919	Ketonuria
HP:0003076	Glycosuria
HP:0003077	Hyperlipidemia
HP:0003162	Fasting hypoglycemia
HP:0004322	Short stature
HP:0011024	Abnormality of the gastrointestinal tract
HP:0011998	Postprandial hyperglycemia
HP:0012734	Ketotic hypoglycemia

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:2089	glycogen storage disorder due to hepatic glycogen synthase deficiency
OMIM:240600	glycogen storage disorder due to hepatic glycogen synthase deficiency

PubChem Disease

GHR Health Conditions

Glycogen storage disease type 0

MedGen Diseases

Glycogen storage disorder due to hepatic glycogen synthase deficiency

OMIM Phenotypes

GLYCOGEN STORAGE DISEASE 0, LIVER; GSD0A

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **41 - 50** of 90 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Equus caballus	100064264		HORSE35936
Sus scrofa	100157080		PIGXX26041
Bos taurus	537451		BOVIN30117
Capra hircus	102189015		CAPHI25266
Ovis aries	101118685		SHEEP14813
Oryctolagus cuniculus	100352840		RABIT12193
Cricetulus griseus	100770628		CRIGR10986
Mus musculus	232493	MGI:2385254	MOUSE47653
Rattus norvegicus	25623	RGD:2773	RATNO31170
Cavia porcellus	100720245		CAVPO13030

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024