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MIRAGE

SH3 domain containing kinase binding protein 1

Summary

Gene Symbol

SH3KBP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

30011

PubChem

30011

Alliance of Genome Resources

HGNC:13867

JoGo

SH3KBP1

TogoVar

SH3KBP1

Annotation

Keyword

3D-structure
Alternative splicing
Apoptosis
Cell junction
Coiled coil
Cytoplasmic vesicle
Cytoskeleton
Endocytosis
Host-virus interaction
Kinase
Membrane
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
SH3 domain
SH3-binding
Synaptosome
Ubl conjugation

Proteins

Displaying entries **1 - 10** of 15 in total

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UniProt	Protein Name
A0A8V8TNW8
A0A8V8TP33
A0A8V8TP40
A0A8V8TNT5
A0A8V8TP27
A0A8V8TQF6
Q5JPT2
B7Z6E8
A0A8V8TP63
A0A8V8TP69

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
endocytosis	IEA
apoptotic process	IEA
cytoskeleton organization	IMP	21834987
actin filament organization	IBA
cell-cell signaling	NAS	10679202

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling

cell death [inference]

programmed cell death [inference]

apoptotic process

vesicle-mediated transport [inference]

endocytosis

cell motility [inference]

cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

supramolecular fiber organization [inference]

actin filament organization

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

import into cell [inference]

endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

regulation of lymphocyte activation [inference]

regulation of B cell activation [inference]

positive regulation of B cell activation

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

signaling [inference]

cell-cell signaling

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

positive regulation of cellular process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of cell shape

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

regulation of lymphocyte activation [inference]

regulation of B cell activation [inference]

positive regulation of B cell activation

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

regulation of lymphocyte activation [inference]

regulation of B cell activation [inference]

positive regulation of B cell activation

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of B cell activation

regulation of biological quality [inference]

regulation of cell shape

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
cytoplasm	IDA	20221403 25468996
cytosol	TAS
cytoskeleton	IEA
plasma membrane	TAS
cell-cell junction	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane

cell junction [inference]

synapse [inference]

anchoring junction [inference]

cell-cell junction

cell-substrate junction [inference]

focal adhesion

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

postsynaptic specialization [inference]

postsynaptic density

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	10679202 12177062 14596919 15090612 15962011 16164598 16228008 16256071 16751601 17255943 17306257 18641129 18680311 19111555 19268472 20221403 20551902 20711168 21516116 21900206 23178720 23663663 25036637 28514442 31413325 31980649 32296183 32814053 33961781
SH3 domain binding	IEA
ubiquitin protein ligase binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

protein domain specific binding [inference]

SH3 domain binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

SH3 domain-containing kinase-binding protein 1

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
actin filament organization
cell migration

Displaying **all 4** entries
InterPro
SH3 domain-containing kinase-binding protein 1, second SH3 domain
SH3 domain-containing kinase-binding protein 1, third SH3 domain
SH3 domain
SH3-like domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111999	immunodeficiency 61	Alliance of Genome Resources

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026