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hbaa1 hemoglobin, alpha adult 1 [ Danio rerio (zebrafish) ]

Gene ID: 30507, updated on 9-Dec-2024

Summary

Official Symbol
hbaa1provided by ZNC
Official Full Name
hemoglobin, alpha adult 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-980526-79
See related
Ensembl:ENSDARG00000097011 AllianceGenome:ZFIN:ZDB-GENE-980526-79
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
AA1; hbaa1.1; dZ118J2.2
Summary
Predicted to enable several functions, including heme binding activity; oxygen binding activity; and oxygen carrier activity. Predicted to contribute to haptoglobin binding activity and peroxidase activity. Acts upstream of or within response to hypoxia. Predicted to be part of haptoglobin-hemoglobin complex and hemoglobin complex. Is expressed in eye; hematopoietic system; presumptive blood; and vasculature. Human ortholog(s) of this gene implicated in Heinz body anemia; alpha thalassemia; familial erythrocytosis 7; and hemoglobin H disease. Orthologous to several human genes including HBA1 (hemoglobin subunit alpha 1) and HBZ (hemoglobin subunit zeta). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See hbaa1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (55100112..55100936)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (54845510..54846331)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene hemoglobin, alpha adult 2 Neighboring gene ba1 globin, like Neighboring gene si:ch211-5k11.8 Neighboring gene hemoglobin, beta adult 1

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
contributes_to haptoglobin binding  
enables heme binding  
enables heme binding  
enables iron ion binding  
enables metal ion binding  
enables oxygen binding  
enables oxygen binding  
enables oxygen carrier activity  
enables oxygen carrier activity  
contributes_to peroxidase activity  
Component Evidence Code Pubs
part_of haptoglobin-hemoglobin complex  
part_of hemoglobin complex  
part_of hemoglobin complex  

General protein information

Preferred Names
hemoglobin subunit alpha
Names
alpha-globin aa1
hemoglobin alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131257.3NP_571332.3  hemoglobin subunit alpha

    Status: VALIDATED

    Source sequence(s)
    AL935210
    UniProtKB/Swiss-Prot
    Q90487
    UniProtKB/TrEMBL
    E7F4I1, Q1JQ69, Q803Z5
    Related
    ENSDARP00000101541.3, ENSDART00000113098.5
    Conserved Domains (1) summary
    cd08927
    Location:3143
    Hb-alpha_like; Hemoglobin alpha, zeta, mu, theta, and related Hb subunits

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    55100112..55100936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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