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MYC proto-oncogene, bHLH transcription factor a

Summary

Gene Symbol

myca

Organism

Danio rerio (zebrafish)

External Links

NCBI Gene

30686

PubChem

30686

Alliance of Genome Resources

ZFIN:ZDB-GENE-990415-162

Annotation

Keyword

Activator
Alternative initiation
DNA-binding
Glycoprotein
Nucleus
Proto-oncogene
Reference proteome
Transcription regulation

Proteins

Displaying 1 entry
UniProt	Protein Name
P52160

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
positive regulation of cell population proliferation	IBA
regulation of vasculature development	IGI	24940000
regulation of transcription by RNA polymerase II	IBA
regulation of DNA-templated transcription	IEA
regulation of transcription, DNA-templated	IEA

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation [inference]

hematopoietic stem cell differentiation

stem cell differentiation [inference]

hematopoietic stem cell differentiation

developmental process [inference]

anatomical structure development [inference]

system development [inference]

vasculature development

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation [inference]

hematopoietic stem cell differentiation

stem cell differentiation [inference]

hematopoietic stem cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of developmental process [inference]

regulation of multicellular organismal development [inference]

regulation of vasculature development

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of vasculature development

Displaying 1 entry
GO Term	Evidence Code	PMID
nucleus	IEA ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
DNA binding	IEA ISS
protein dimerization activity	IEA
DNA-binding transcription factor activity, RNA polymerase II-specific	IBA ISS
DNA-binding transcription factor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

protein dimerization activity

organic cyclic compound binding [inference]

nucleic acid binding [inference]

transcription regulatory region nucleic acid binding [inference]

transcription cis-regulatory region binding [inference]

RNA polymerase II transcription regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

cis-regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA binding

double-stranded DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

transcription cis-regulatory region binding [inference]

RNA polymerase II transcription regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

cis-regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

transcription cis-regulatory region binding [inference]

RNA polymerase II transcription regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

cis-regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

transcription regulator activity [inference]

DNA-binding transcription factor activity

DNA-binding transcription factor activity, RNA polymerase II-specific

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Myc

Functional Category

I: Lipid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
protein dimerization activity

Displaying **all 4** entries
InterPro
Helix-loop-helix DNA-binding domain superfamily
Myc-type, basic helix-loop-helix (bHLH) domain
Transcription regulator Myc, N-terminal
Transcription regulator Myc

Disease

Disease Ontology

Displaying entries **1 - 10** of 34 in total

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DO ID	Disease Name	Source
DOID:0001816	angiosarcoma	Alliance of Genome Resources
DOID:0060318	acute promyelocytic leukemia	Alliance of Genome Resources
DOID:0080322	polycystic kidney disease	Alliance of Genome Resources
DOID:0110858	polycystic kidney disease 1	Alliance of Genome Resources
DOID:10283	prostate cancer	Alliance of Genome Resources
DOID:1040	chronic lymphocytic leukemia	Alliance of Genome Resources
DOID:11054	urinary bladder cancer	Alliance of Genome Resources
DOID:11132	prostatic hypertrophy	Alliance of Genome Resources
DOID:11476	osteoporosis	Alliance of Genome Resources
DOID:127	leiomyoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **305** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	4609	HGNC:7553	HUMAN95470
Mus musculus	17869	MGI:97250	MOUSE15232
Rattus norvegicus	24577	RGD:3130	RATNO39369
Drosophila melanogaster	31310	FB:FBgn0262656
Mus musculus	107771	MGI:88184
Rattus norvegicus	311807	RGD:1584970
Xenopus tropicalis	395024	Xenbase:XB-GENE-6052814
Canis lupus familiaris	403924		CANLF03214
Sus scrofa	448810		PIGXX22869
Pan troglodytes	464393		PANTR43255