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fn1b fibronectin 1b [ Danio rerio (zebrafish) ]

Gene ID: 334613, updated on 9-Dec-2024

Summary

Official Symbol
fn1bprovided by ZNC
Official Full Name
fibronectin 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6545
See related
Ensembl:ENSDARG00000006526 AllianceGenome:ZFIN:ZDB-GENE-030131-6545
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fn3; fn1l; cb1057; wu:fa14f11; wu:fb03c02
Summary
Predicted to enable integrin binding activity and proteoglycan binding activity. Acts upstream of or within atrioventricular valve morphogenesis; heart field specification; and somitogenesis. Predicted to be located in extracellular space. Is expressed in several structures, including fin; heart; integument; mesoderm; and musculature system. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis; membranoproliferative glomerulonephritis; and spondylometaphyseal dysplasia corner fracture type. Orthologous to human FN1 (fibronectin 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See fn1b in Genome Data Viewer
Location:
chromosome: 1
Exon count:
46
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (5504128..5543079, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (4806328..4845286, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene motor neuron and pancreas homeobox 2b Neighboring gene 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Neighboring gene carboxypeptidase O Neighboring gene neuropilin 2a

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Pathways from PubChem

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables heparin binding  
enables integrin binding  
enables proteoglycan binding  
Process Evidence Code Pubs
acts_upstream_of_or_within acute-phase response  
acts_upstream_of_or_within atrioventricular valve morphogenesis PubMed 
acts_upstream_of_or_within cell adhesion  
involved_in cell-matrix adhesion  
involved_in cell-substrate junction assembly  
involved_in heart development  
acts_upstream_of_or_within heart field specification PubMed 
involved_in nervous system development  
acts_upstream_of_or_within regulation of cell shape  
acts_upstream_of_or_within somitogenesis PubMed 
acts_upstream_of_or_within somitogenesis PubMed 
Component Evidence Code Pubs
located_in extracellular region  
located_in extracellular space  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013261.1NP_001013279.1  fibronectin 1b precursor

    See identical proteins and their annotated locations for NP_001013279.1

    Status: PROVISIONAL

    Source sequence(s)
    AY538257
    UniProtKB/TrEMBL
    Q6JAN2
    Conserved Domains (6) summary
    smart00059
    Location:421469
    FN2; Fibronectin type 2 domain
    smart00058
    Location:22782320
    FN1; Fibronectin type 1 domain
    cd00061
    Location:23232360
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:12701358
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:235274
    fn1; Fibronectin type I domain
    pfam00041
    Location:14521533
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    5504128..5543079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005160284.4XP_005160341.1  fibronectin 1b isoform X1

    UniProtKB/TrEMBL
    A0A8M2B744
    Conserved Domains (6) summary
    smart00059
    Location:421469
    FN2; Fibronectin type 2 domain
    smart00058
    Location:22772319
    FN1; Fibronectin type 1 domain
    cd00061
    Location:23202359
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:12691357
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:235274
    fn1; Fibronectin type I domain
    pfam00041
    Location:14511532
    fn3; Fibronectin type III domain
  2. XM_009305554.4XP_009303829.1  fibronectin 1b isoform X2

    UniProtKB/TrEMBL
    A0A8M3BD92, A2CEW3
    Related
    ENSDARP00000094530.2, ENSDART00000103755.4
    Conserved Domains (6) summary
    smart00059
    Location:421469
    FN2; Fibronectin type 2 domain
    smart00058
    Location:23702412
    FN1; Fibronectin type 1 domain
    cd00061
    Location:24132452
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:13621450
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:235274
    fn1; Fibronectin type I domain
    pfam00041
    Location:15441625
    fn3; Fibronectin type III domain
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