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Serpin 28Dc

Summary

Gene Symbol

Spn28Dc

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

34091

PubChem

34091

Alliance of Genome Resources

FB:FBgn0031973

Annotation

Keyword

Developmental protein
Glycoprotein
Immunity
Melanin biosynthesis
Reference proteome
Secreted
Serine protease inhibitor
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9VLU4	Serpin-28D

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
response to wounding	IMP	18801354
melanin biosynthetic process
negative regulation of proteolysis	IMP ISM	18801354 19849829
negative regulation of melanization defense response	IMP	18801354
immune system process

GO Hierarchy

biological process

immune system process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

secondary metabolite biosynthetic process [inference]

melanin biosynthetic process

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

organic hydroxy compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

secondary metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process

secondary metabolite biosynthetic process [inference]

melanin biosynthetic process

pigment metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process

pigment biosynthetic process [inference]

melanin biosynthetic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

cellular biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

organic substance metabolic process [inference]

organic cyclic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

organic cyclic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

organic hydroxy compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

organic hydroxy compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

cellular biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

response to stimulus [inference]

response to stress [inference]

response to wounding

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of melanization defense response

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of melanization defense response [inference]

negative regulation of melanization defense response

negative regulation of innate immune response [inference]

negative regulation of melanization defense response

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of melanization defense response

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of cellular metabolic process [inference]

negative regulation of melanization defense response

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of melanization defense response

regulation of melanization defense response [inference]

negative regulation of melanization defense response

regulation of secondary metabolic process [inference]

regulation of melanization defense response [inference]

negative regulation of melanization defense response

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of melanization defense response

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of cellular metabolic process [inference]

negative regulation of melanization defense response

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of melanization defense response

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of melanization defense response

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of melanization defense response

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of melanization defense response

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of melanization defense response

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of melanization defense response

regulation of innate immune response [inference]

regulation of melanization defense response [inference]

negative regulation of melanization defense response

negative regulation of innate immune response [inference]

negative regulation of melanization defense response

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of melanization defense response

regulation of innate immune response [inference]

regulation of melanization defense response [inference]

negative regulation of melanization defense response

negative regulation of innate immune response [inference]

negative regulation of melanization defense response

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of melanization defense response

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of melanization defense response

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of melanization defense response

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of melanization defense response

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of melanization defense response [inference]

negative regulation of melanization defense response

negative regulation of innate immune response [inference]

negative regulation of melanization defense response

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of melanization defense response

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of melanization defense response

regulation of innate immune response [inference]

regulation of melanization defense response [inference]

negative regulation of melanization defense response

negative regulation of innate immune response [inference]

negative regulation of melanization defense response

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of melanization defense response

regulation of melanization defense response [inference]

negative regulation of melanization defense response

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of melanization defense response

Displaying 1 entry
GO Term	Evidence Code	PMID
extracellular space	IBA IEA IMP ISM	18801354 19849829

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

Displaying 1 entry
GO Term	Evidence Code	PMID
serine-type endopeptidase inhibitor activity	IEA

GO Hierarchy

molecular function

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Serpin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
serine-type endopeptidase inhibitor activity

Displaying **all 5** entries
InterPro
Serpin domain
Serpin family
Serpin superfamily, domain 1
Serpin superfamily, domain 2
Serpin superfamily

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
membrane	FB:FBrf0231198

Disease

Disease Ontology

Displaying entries **1 - 10** of 52 in total

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DO ID	Disease Name	Source
DOID:0060186	chemical colitis	Alliance of Genome Resources
DOID:0060189	ileitis	Alliance of Genome Resources
DOID:0060601	alpha-2-plasmin inhibitor deficiency	Alliance of Genome Resources
DOID:0080600	COVID-19	Alliance of Genome Resources
DOID:0080939	hereditary angioedema type I	Alliance of Genome Resources
DOID:0080998	acute necrotizing pancreatitis	Alliance of Genome Resources
DOID:0090030	corticosteroid-binding globulin deficiency	Alliance of Genome Resources
DOID:10591	pre-eclampsia	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:11394	adult respiratory distress syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **103** in total

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Species	Gene ID	Alliance of Genome Resources
Homo sapiens	12	HGNC:16
Homo sapiens	710	HGNC:1228
Homo sapiens	866	HGNC:1540
Homo sapiens	5104	HGNC:8723
Homo sapiens	5265	HGNC:8941
Homo sapiens	5267	HGNC:8948
Homo sapiens	5345	HGNC:9075
Homo sapiens	6906	HGNC:11583
Mus musculus	12258	MGI:894696
Mus musculus	12401	MGI:88278

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements