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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
insulin receptor
Summary
- Gene Symbol
-
- INSR
- Aliases
-
- CD220
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Carbohydrate metabolism
- Cell membrane
- Cleavage on pair of basic residues
- Diabetes mellitus
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Endosome
- Glycoprotein
- Lysosome
- Phosphoprotein
- Receptor
- Reference proteome
- Repeat
- S-nitrosylation
- Signal
- Transmembrane helix
- Tyrosine-protein kinase
- Proteins
| UniProt | Protein Name |
|---|---|
| P06213 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of cell population proliferation | ||
| amyloid-beta clearance | ||
| positive regulation of protein-containing complex disassembly | ||
| positive regulation of developmental growth | ||
| positive regulation of glycolytic process |
GO Hierarchy
- positive regulation of respiratory burst
- positive regulation of respiratory burst
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of nitrogen compound metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of small molecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of nitrogen compound metabolic process [inference]
positive regulation of cellular process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
positive regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of molecular function [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| external side of plasma membrane | ||
| membrane | ||
| late endosome | ||
| receptor complex | ||
| neuronal cell body membrane |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- insulin receptor a
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050470 | Donohue syndrome | |
| DOID:0050741 | alcohol dependence | |
| DOID:0060071 | pre-malignant neoplasm | |
| DOID:0070220 | familial hyperinsulinemic hypoglycemia 5 | |
| DOID:0080208 | metabolic dysfunction-associated steatotic liver disease | |
| DOID:10605 | short bowel syndrome | |
| DOID:10652 | Alzheimer's disease | |
| DOID:11714 | gestational diabetes | |
| DOID:13413 | hepatic encephalopathy | |
| DOID:14330 | Parkinson's disease |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000006 | Autosomal dominant inheritance |
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000040 | Long penis |
| HP:0000065 | Labial hypertrophy |
| HP:0000105 | Enlarged kidney |
| HP:0000121 | Nephrocalcinosis |
| HP:0000138 | Ovarian cyst |
| HP:0000154 | Wide mouth |
| HP:0000158 | Macroglossia |
| HP:0000164 | Abnormality of the dentition |
| Disease ID | Disease Name |
|---|---|
| ORPHA:263458 |
|
| OMIM:609968 |
|
| ORPHA:508 |
|
| ORPHA:2297 |
|
| OMIM:262190 |
|
| OMIM:246200 |
|
| ORPHA:769 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 16337 | MGI:96575 | MOUSE59075 | ||
| 24954 | RGD:2917 | RATNO05588 | ||
| 42549 | FB:FBgn0283499 | |||
| 175410 | WB:WBGene00000898 | |||
| 245699 | ZFIN:ZDB-GENE-020503-3 | DANRE29770 | ||
| 245700 | ZFIN:ZDB-GENE-020503-4 | DANRE22677 | ||
| 396755 | PIGXX18653 | |||
| 398006 | Xenbase:XB-GENE-920741 | |||
| 443431 | SHEEP16313 | |||
| 455649 | 9598_0:004ba3 | PANTR16965 |
ChIP-Atlas
- Target Genes
-
Predicted target genes bound by given transcription factors. Target Genes
Potential target genes for INSR
Distance from TSS: ± 10 kb
| Gene Symbol | Description | Cellline (score) |
|---|---|---|
| dolichyl-phosphate mannosyltransferase subunit 3, regulatory |
|
|
| mutY DNA glycosylase |
|
|
| hexosaminidase subunit beta |
|
|
| ectonucleotide pyrophosphatase/phosphodiesterase 3 |
|
|
| fucosyltransferase 1 (H blood group) |
|
|
| phosphatidylinositol glycan anchor biosynthesis class G (EMM blood group) |
|
|
| phospholipase A2 group IIA |
|
|
| hyaluronidase 3 |
|
|
| beta-1,3-galactosyltransferase 4 |
|
|
| transmembrane O-mannosyltransferase targeting cadherins 3 |
|
- Colocalization
-
Predicted partner proteins colocalizing with given transcription factors. Colocalization
Colocalization analysis for INSR
| Gene Symbol | Description | Cellline (score) |
|---|---|---|
| methyl-CpG binding domain 4, DNA glycosylase |
|
|
| structural maintenance of chromosomes flexible hinge domain containing 1 |
|
|
| histone deacetylase 2 |
|
|
| decapping mRNA 1A |
|
|
| INO80 complex ATPase subunit |
|
|
| insulin receptor |
|
