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STT3 oligosaccharyltransferase complex catalytic subunit A

Summary

Gene Symbol

STT3A

Aliases

MGC9042
STT3-A
TMC
dolichyl-diphosphooligosaccharide protein glycotransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

3703

HGNC

6172

KEGG Gene ID

hsa:3703

PubChem

3703

Alliance of Genome Resources

HGNC:6172

Annotation

Keyword

3D-structure
Alternative splicing
Congenital disorder of glycosylation
Disease variant
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Magnesium
Manganese
Metal-binding
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P46977	B5 Integral membrane protein 1 Transmembrane protein TMC

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
protein N-linked glycosylation	NAS	31831667
protein N-linked glycosylation	IMP	22467853
protein N-linked glycosylation via asparagine	ISS
protein N-linked glycosylation via asparagine	IDA	31296534 38670073
protein N-linked glycosylation via asparagine	IMP	19167329

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

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GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	NAS	31831667
endoplasmic reticulum membrane	TAS
oligosaccharyltransferase complex	ISS
oligosaccharyltransferase complex	NAS	31831667
oligosaccharyltransferase complex	TAS	19167329

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

oligosaccharyltransferase complex

oligosaccharyltransferase III complex

endoplasmic reticulum protein-containing complex [inference]

oligosaccharyltransferase complex

oligosaccharyltransferase III complex

catalytic complex [inference]

transferase complex [inference]

oligosaccharyltransferase complex

oligosaccharyltransferase III complex

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
dolichyl-diphosphooligosaccharide-protein glycotransferase activity	ISS
dolichyl-diphosphooligosaccharide-protein glycotransferase activity	IDA	31296534 38670073 39509507
dolichyl-diphosphooligosaccharide-protein glycotransferase activity	IMP	19167329 22467853
dolichyl-diphosphooligosaccharide-protein glycotransferase activity	IBA
protein binding	IPI	21903422 30021884 32707033 32814053 33845483 35271311 36217030

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

oligosaccharyl transferase activity [inference]

dolichyl-diphosphooligosaccharide-protein glycotransferase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

subunit of the

Functional Category

O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
dolichyl-diphosphooligosaccharide-protein glycotransferase activity
metal ion binding
oligosaccharyl transferase activity
post-translational protein modification
protein N-linked glycosylation via asparagine
transferase activity

Displaying **all 3** entries
InterPro
Oligosaccharyl transferase STT3, N-terminal domain
Oligosaccharyl transferase, STT3 subunit
STT3/PglB/AglB, core domain

KEGG BRITE Database

Orthology

K07151

Name

dolichyl-diphosphooligosaccharide---protein glycosyltransferase [EC:2.4.99.18]

References

12887896

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05976	2.4.99.18	G72079JG	G57930PW

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080572	congenital disorder of glycosylation Iw	Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0000028	Cryptorchidism
HP:0000046	Small scrotum
HP:0000054	Micropenis
HP:0000219	Thin upper lip vermilion
HP:0000252	Microcephaly
HP:0000256	Macrocephaly
HP:0000276	Long face
HP:0000303	Mandibular prognathia

Displaying **all 3** entries
Disease ID	Disease Name
OMIM:619714	congenital disorder of glycosylation, type Iw, autosomal dominant
OMIM:615596	STT3A-congenital disorder of glycosylation
ORPHA:370921	STT3A-congenital disorder of glycosylation

PubChem Disease

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Congenital disorders of glycosylation type I

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP003635
Gene Name: STT3A, subunit of the oligosaccharyltransferase complex (catalytic)

Ortholog

Displaying entries **31 - 40** of 91 in total

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Species	Gene ID	Orthologous MAtrix
Oreochromis niloticus	100708489	ORENI02690
Cavia porcellus	100720801	CAVPO10178
Cricetulus griseus	100751391	CRIGR21360
Otolemur garnettii	100941691	OTOGA06022
Pan paniscus	100981439	PANPA08255
Papio anubis	101016874	PAPAN04920
Saimiri boliviensis boliviensis	101043918	SAIBB06280
Felis catus	101083108	FELCA24655
Ovis aries	101110978	SHEEP10933
Gorilla gorilla gorilla	101133351	GORGO03556

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements