U.S. flag

An official website of the United States government

itm2b.L integral membrane protein 2B L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 380074, updated on 9-Dec-2024

Summary

Official Symbol
itm2b.L
Official Full Name
integral membrane protein 2B L homeolog
Primary source
Xenbase:XB-GENE-986233
Locus tag
XELAEV_18013284mg
See related
EnsemblRapid:ENSXLAG00005002286 AllianceGenome:Xenbase:XB-GENE-986233
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
itm2b
Summary
Predicted to enable amyloid-beta binding activity. Predicted to act upstream of or within negative regulation of amyloid precursor protein biosynthetic process. Predicted to be located in bounding membrane of organelle; extracellular exosome; and plasma membrane. Human ortholog(s) of this gene implicated in ITM2B-related cerebral amyloid angiopathy 1 and ITM2B-related cerebral amyloid angiopathy 2. Orthologous to human ITM2B (integral membrane protein 2B). [provided by Alliance of Genome Resources, Dec 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See itm2b.L in Genome Data Viewer
Location:
chromosome: 2L
Exon count:
6
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2L NC_054373.1 (141411050..141435972)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2L NC_030726.1 (135523136..135548058)

Chromosome 2L - NC_054373.1Genomic Context describing neighboring genes Neighboring gene nudix hydrolase 15 L homeolog Neighboring gene mediator complex subunit 4 L homeolog Neighboring gene lysophosphatidic acid receptor 6 L homeolog Neighboring gene activin A receptor like type 1 L homeolog

Genomic regions, transcripts, and products

General gene information

Clone Names

  • MGC52745

Gene Ontology Provided by Xenbase

Component Evidence Code Pubs
located_in Golgi apparatus  
located_in Golgi membrane  
located_in endosome  
located_in endosome membrane  
located_in plasma membrane  

General protein information

Preferred Names
integral membrane protein 2B L homeolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086913.1NP_001080382.1  integral membrane protein 2B L homeolog

    See identical proteins and their annotated locations for NP_001080382.1

    Status: PROVISIONAL

    Source sequence(s)
    BC042345
    UniProtKB/TrEMBL
    A0A974HZH5, Q8AVF1
    Related
    ENSXLAP00005006876.1, ENSXLAT00005006985.1
    Conserved Domains (1) summary
    smart01039
    Location:127221
    BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054373.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    141411050..141435972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
External link. Please review our privacy policy.