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cytochrome P450 family 11 subfamily A member 1

Summary

Gene Symbol

CYP11A1

Organism

Sus scrofa (pig)

External Links

NCBI Gene: 403329
KEGG Gene ID: ssc:403329
PubChem: 403329

Annotation

Keyword

Cholesterol metabolism
Direct protein sequencing
Heme
Membrane
Mitochondrion
Mitochondrion inner membrane
Monooxygenase
Reference proteome
Steroidogenesis
Transit peptide

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P10612	CYPXIA1 Cholesterol desmolase Cytochrome P450 11A1 Cytochrome P450(scc)
F1D8K7	Cholesterol desmolase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
C21-steroid hormone biosynthetic process	IEA	30032202
glucocorticoid biosynthetic process	IEA	30032202
cholesterol metabolic process	IEA	30032202
cortisol metabolic process	IEA	30032202
cellular response to peptide hormone stimulus	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process

cellular biosynthetic process [inference]

C21-steroid hormone biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

hormone metabolic process [inference]

C21-steroid hormone metabolic process [inference]

C21-steroid hormone biosynthetic process

hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

cortisol metabolic process

cellular biosynthetic process [inference]

C21-steroid hormone biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

C21-steroid hormone metabolic process [inference]

C21-steroid hormone biosynthetic process

glucocorticoid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

cortisol metabolic process

tertiary alcohol metabolic process [inference]

cortisol metabolic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process

cellular ketone metabolic process [inference]

cortisol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

C21-steroid hormone metabolic process [inference]

C21-steroid hormone biosynthetic process

glucocorticoid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

cellular ketone metabolic process [inference]

cortisol metabolic process

olefinic compound metabolic process [inference]

cortisol metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

C21-steroid hormone metabolic process [inference]

C21-steroid hormone biosynthetic process

glucocorticoid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

cortisol metabolic process

tertiary alcohol metabolic process [inference]

cortisol metabolic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

C21-steroid hormone metabolic process [inference]

C21-steroid hormone biosynthetic process

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

cortisol metabolic process

cellular biosynthetic process [inference]

C21-steroid hormone biosynthetic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus

response to peptide hormone [inference]

cellular response to peptide hormone stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus

response to peptide hormone [inference]

cellular response to peptide hormone stimulus

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

response to peptide [inference]

response to peptide hormone [inference]

cellular response to peptide hormone stimulus

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

response to peptide [inference]

response to peptide hormone [inference]

cellular response to peptide hormone stimulus

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

cellular response to peptide hormone stimulus

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

C21-steroid hormone metabolic process [inference]

C21-steroid hormone biosynthetic process

hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
mitochondrial inner membrane	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
monooxygenase activity	IEA	22301074
iron ion binding	IEA	22301074
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA	22301074
heme binding	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cytochrome p450

Functional Category

C: Energy production and conversion
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
heme binding
iron ion binding
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity

Displaying **all 4** entries
InterPro
Cytochrome P450 superfamily
Cytochrome P450, E-class, group I
Cytochrome P450, conserved site
Cytochrome P450

KEGG BRITE Database

Orthology

K00498

Name

cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6]

References

Rhea

RHEA:35739

H⁺ + O₂ + cholesterol

H₂O + pregnenolone + 4-methylpentanal

Enzyme

1.14.15.6

PMID

Ortholog

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	1583	HUMAN24141
Mus musculus	13070	MOUSE62016
Rattus norvegicus	29680	RATNO41971
Danio rerio	80374	DANRE27258
Bos taurus	338048	BOVIN16668
Canis lupus familiaris	478365	CANLF12689
Macaca mulatta	708065	MACMU40942
Pan troglodytes	748998	PANTR10791
Monodelphis domestica	100029519	MONDO06501
Equus caballus	100034229	HORSE17259