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microtubule associated protein 2

Summary

Gene Symbol

MAP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

4133

PubChem

4133

Alliance of Genome Resources

HGNC:6839

Annotation

Keyword

Alternative splicing
Calmodulin-binding
Cell projection
Cytoskeleton
Microtubule
Phosphoprotein
Proteomics identification
Reference proteome
Repeat

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q6NYC5
P11137
A0A024R3Z1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
microtubule cytoskeleton organization	IBA ISS
negative regulation of axon extension	ISS
regulation of protein localization	ISS
regulation of microtubule polymerization	TAS	10640627
positive regulation of anterograde dense core granule transport	ISS

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization

cellular developmental process [inference]

cell development [inference]

neuron development [inference]

central nervous system neuron development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

plasma membrane bounded cell projection organization [inference]

neuron projection development

dendrite development

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

anatomical structure development [inference]

dendrite development

cell development [inference]

neuron development [inference]

central nervous system neuron development

cellular developmental process [inference]

cell development [inference]

neuron development [inference]

central nervous system neuron development

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of vesicle transport along microtubule [inference]

positive regulation of cytoplasmic transport [inference]

positive regulation of dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

regulation of organelle transport along microtubule

regulation of vesicle transport along microtubule [inference]

positive regulation of vesicle transport along microtubule [inference]

regulation of anterograde dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

regulation of anterograde synaptic vesicle transport [inference]

positive regulation of anterograde synaptic vesicle transport

regulation of cytoplasmic transport [inference]

positive regulation of cytoplasmic transport [inference]

positive regulation of dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

regulation of dense core granule transport [inference]

regulation of anterograde dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

positive regulation of dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of vesicle transport along microtubule [inference]

positive regulation of cytoplasmic transport [inference]

positive regulation of dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

positive regulation of synaptic vesicle transport [inference]

positive regulation of anterograde synaptic vesicle transport

regulation of synaptic vesicle transport [inference]

positive regulation of synaptic vesicle transport [inference]

positive regulation of anterograde synaptic vesicle transport

regulation of anterograde synaptic vesicle transport [inference]

positive regulation of anterograde synaptic vesicle transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of vesicle transport along microtubule [inference]

positive regulation of cytoplasmic transport [inference]

positive regulation of dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

regulation of organelle transport along microtubule

regulation of vesicle transport along microtubule [inference]

positive regulation of vesicle transport along microtubule [inference]

regulation of anterograde dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

regulation of anterograde synaptic vesicle transport [inference]

positive regulation of anterograde synaptic vesicle transport

regulation of cytoplasmic transport [inference]

positive regulation of cytoplasmic transport [inference]

positive regulation of dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

regulation of dense core granule transport [inference]

regulation of anterograde dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

positive regulation of dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

regulation of protein localization

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension

negative regulation of growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension

negative regulation of developmental growth [inference]

negative regulation of axon extension

regulation of developmental growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension

negative regulation of developmental growth [inference]

negative regulation of axon extension

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of vesicle transport along microtubule [inference]

positive regulation of cytoplasmic transport [inference]

positive regulation of dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

positive regulation of synaptic vesicle transport [inference]

positive regulation of anterograde synaptic vesicle transport

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of vesicle transport along microtubule [inference]

positive regulation of cytoplasmic transport [inference]

positive regulation of dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

positive regulation of synaptic vesicle transport [inference]

positive regulation of anterograde synaptic vesicle transport

negative regulation of biological process [inference]

negative regulation of growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension

negative regulation of developmental growth [inference]

negative regulation of axon extension

negative regulation of cellular process [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule polymerization

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of developmental growth [inference]

negative regulation of axon extension

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of axonogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of developmental growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension

negative regulation of developmental growth [inference]

negative regulation of axon extension

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of developmental growth [inference]

negative regulation of axon extension

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of cellular process [inference]

regulation of microtubule-based process [inference]

regulation of microtubule-based movement [inference]

regulation of organelle transport along microtubule

regulation of vesicle transport along microtubule [inference]

positive regulation of vesicle transport along microtubule [inference]

regulation of anterograde dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

regulation of anterograde synaptic vesicle transport [inference]

positive regulation of anterograde synaptic vesicle transport

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization

regulation of microtubule polymerization

negative regulation of microtubule polymerization

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

regulation of protein polymerization [inference]

regulation of microtubule polymerization

negative regulation of microtubule polymerization

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of vesicle transport along microtubule [inference]

positive regulation of cytoplasmic transport [inference]

positive regulation of dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

positive regulation of synaptic vesicle transport [inference]

positive regulation of anterograde synaptic vesicle transport

negative regulation of cellular process [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule polymerization

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of axonogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization

regulation of cytoskeleton organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization

regulation of microtubule polymerization

negative regulation of microtubule polymerization

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

regulation of protein polymerization [inference]

regulation of microtubule polymerization

negative regulation of microtubule polymerization

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule polymerization

regulation of supramolecular fiber organization [inference]

regulation of microtubule polymerization

negative regulation of microtubule polymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule polymerization

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of vesicle transport along microtubule [inference]

positive regulation of cytoplasmic transport [inference]

positive regulation of dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

regulation of organelle transport along microtubule

regulation of vesicle transport along microtubule [inference]

positive regulation of vesicle transport along microtubule [inference]

regulation of anterograde dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

regulation of anterograde synaptic vesicle transport [inference]

positive regulation of anterograde synaptic vesicle transport

regulation of cytoplasmic transport [inference]

positive regulation of cytoplasmic transport [inference]

positive regulation of dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

regulation of dense core granule transport [inference]

regulation of anterograde dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

positive regulation of dense core granule transport [inference]

positive regulation of anterograde dense core granule transport

regulation of protein localization

regulation of synaptic vesicle transport [inference]

positive regulation of synaptic vesicle transport [inference]

positive regulation of anterograde synaptic vesicle transport

regulation of anterograde synaptic vesicle transport [inference]

positive regulation of anterograde synaptic vesicle transport

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of binding [inference]

negative regulation of protein binding [inference]

negative regulation of microtubule binding

regulation of binding [inference]

regulation of protein binding [inference]

negative regulation of protein binding [inference]

negative regulation of microtubule binding

regulation of microtubule binding [inference]

negative regulation of microtubule binding

negative regulation of binding [inference]

negative regulation of protein binding [inference]

negative regulation of microtubule binding

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
apical distal dendrite	ISS
microtubule	IEA
axon hillock	ISS
microtubule associated complex	TAS	9588626
primary dendrite	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

microtubule associated complex

cellular anatomical entity [inference]

cytoplasm

cytoplasmic region [inference]

plasma membrane bounded cell projection cytoplasm [inference]

neuron projection cytoplasm [inference]

dendrite cytoplasm

cytosol

site of polarized growth [inference]

growth cone [inference]

dendritic growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

dendrite

dendritic branch

apical dendrite [inference]

apical distal dendrite

distal dendrite

apical distal dendrite

proximal dendrite

actin-based cell projection [inference]

filopodium [inference]

dendritic filopodium

dendrite terminus [inference]

dendritic growth cone

cell body [inference]

neuronal cell body

main axon

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	20195357 32814053
calmodulin binding	IEA
dystroglycan binding	IPI	18341635
tau protein binding	NAS	28386764
microtubule binding	IBA TAS	26609151

GO Hierarchy

molecular function

structural molecule activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding

tau protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

microtubule-associated protein

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
microtubule binding
microtubule cytoskeleton organization
neuron projection development
tubulin binding

Displaying **all 2** entries
InterPro
Microtubule associated protein MAP2/MAP4/Tau
Microtubule associated protein, tubulin-binding repeat

Disease

Disease Ontology

Displaying **all 10** entries
DO ID	Disease Name	Source
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:11088	asphyxia neonatorum	Alliance of Genome Resources
DOID:11294	arteriovenous malformation	Alliance of Genome Resources
DOID:11446	sciatic neuropathy	Alliance of Genome Resources
DOID:12217	Lewy body dementia	Alliance of Genome Resources
DOID:12858	Huntington's disease	Alliance of Genome Resources
DOID:2316	brain ischemia	Alliance of Genome Resources
DOID:3328	temporal lobe epilepsy	Alliance of Genome Resources
DOID:3526	cerebral infarction	Alliance of Genome Resources
DOID:5419	schizophrenia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 65 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	17756		MGI:97175	MOUSE29848
Rattus norvegicus	25595		RGD:3044	RATNO43669
Bos taurus	281294			BOVIN24675
Xenopus laevis	379931		Xenbase:XB-GENE-5945253
Danio rerio	450004		ZFIN:ZDB-GENE-041010-118
Pan troglodytes	459909	9598_0:000d84		PANTR29657
Canis lupus familiaris	488504			CANLF14179
Macaca mulatta	710840			MACMU06676
Xenopus tropicalis	780043		Xenbase:XB-GENE-5945202
Ornithorhynchus anatinus	100076829			ORNAN24140

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements