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grhpra glyoxylate reductase/hydroxypyruvate reductase a [ Danio rerio (zebrafish) ]

Gene ID: 497183, updated on 4-Jan-2025

Summary

Official Symbol
grhpraprovided by ZNC
Official Full Name
glyoxylate reductase/hydroxypyruvate reductase aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040724-230
See related
Ensembl:ENSDARG00000068264 AllianceGenome:ZFIN:ZDB-GENE-040724-230
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
grhpr; zgc:109900; si:ch211-240l14.3
Summary
Predicted to enable glyoxylate reductase (NADPH) activity and hydroxypyruvate reductase (NADH) activity. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in primary hyperoxaluria and primary hyperoxaluria type 2. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See grhpra in Genome Data Viewer
Location:
chromosome: 14
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (44777491..44790780, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (44316179..44329468, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene si:ch211-170a17.1 Neighboring gene si:dkey-109l4.3 Neighboring gene translocase of outer mitochondrial membrane 5 homolog (yeast) Neighboring gene zgc:195212 Neighboring gene solute carrier family 30 member 9

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Clone Names

  • MGC109900

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables NAD binding  
enables glyoxylate reductase (NADPH) activity  
enables glyoxylate reductase (NADPH) activity  
enables hydroxypyruvate reductase (NADH) activity  
enables oxidoreductase activity  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor  
Component Evidence Code Pubs
is_active_in cytosol  

General protein information

Preferred Names
glyoxylate reductase/hydroxypyruvate reductase
NP_001018361.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001020525.1NP_001018361.1  glyoxylate reductase/hydroxypyruvate reductase

    See identical proteins and their annotated locations for NP_001018361.1

    Status: PROVISIONAL

    Source sequence(s)
    BC095040
    UniProtKB/TrEMBL
    Q504F9
    Related
    ENSDARP00000089411.4, ENSDART00000098640.6
    Conserved Domains (2) summary
    COG1052
    Location:8326
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05301
    Location:8318
    GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    44777491..44790780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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