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phosphodiesterase 3A

Summary

Gene Symbol

PDE3A

Aliases

CGI-PDE
cGMP-inhibited 3',5'-cyclic phosphodiesterase A

Organism

Homo sapiens (human)

External Links

NCBI Gene

5139

HGNC

8778

PubChem

5139

Alliance of Genome Resources

HGNC:8778

Annotation

Keyword

3D-structure
Cytoplasm
Direct protein sequencing
Disease variant
Hydrolase
Isopeptide bond
Manganese
Metal-binding
Phosphoprotein
Reference proteome
Transmembrane helix
Ubl conjugation
cAMP
cGMP

Proteins

Displaying 1 entry
UniProt	Protein Name
Q14432	Cyclic GMP-inhibited phosphodiesterase A cGMP-inhibited cAMP phosphodiesterase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
oocyte maturation	IEA
lipid metabolic process	TAS	8921398
G protein-coupled receptor signaling pathway	TAS
response to xenobiotic stimulus	IEA
cAMP-mediated signaling	IBA

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process

organic substance metabolic process [inference]

lipid metabolic process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

hormone-mediated signaling pathway [inference]

steroid hormone mediated signaling pathway [inference]

intracellular steroid hormone receptor signaling pathway

intracellular receptor signaling pathway [inference]

intracellular steroid hormone receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

cyclic-nucleotide-mediated signaling [inference]

apoptotic signaling pathway

cellular process involved in reproduction in multicellular organism [inference]

oocyte maturation

cellular developmental process [inference]

cell maturation [inference]

oocyte maturation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cGMP

cellular response to organonitrogen compound [inference]

cellular response to cGMP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cGMP

cellular response to oxygen-containing compound [inference]

cellular response to cGMP

reproductive process [inference]

developmental process involved in reproduction [inference]

oocyte maturation

cellular process involved in reproduction in multicellular organism [inference]

oocyte maturation

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

regulation of vascular permeability [inference]

developmental process [inference]

developmental process involved in reproduction [inference]

oocyte maturation

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation [inference]

oocyte maturation

cellular developmental process [inference]

cell maturation [inference]

oocyte maturation

response to stimulus [inference]

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus [inference]

cellular response to transforming growth factor beta stimulus

response to transforming growth factor beta [inference]

cellular response to transforming growth factor beta stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to transforming growth factor beta stimulus

cellular response to organonitrogen compound [inference]

cellular response to cGMP

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cGMP [inference]

cellular response to cGMP

cellular response to organonitrogen compound [inference]

cellular response to cGMP

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to cGMP [inference]

cellular response to cGMP

cellular response to organic cyclic compound [inference]

cellular response to cGMP

response to organophosphorus [inference]

response to cGMP [inference]

cellular response to cGMP

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cGMP

cellular response to organonitrogen compound [inference]

cellular response to cGMP

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cGMP

cellular response to organonitrogen compound [inference]

cellular response to cGMP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cGMP

cellular response to oxygen-containing compound [inference]

cellular response to cGMP

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cGMP [inference]

cellular response to cGMP

cellular response to organonitrogen compound [inference]

cellular response to cGMP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cGMP

response to oxygen-containing compound [inference]

response to cGMP [inference]

cellular response to cGMP

cellular response to oxygen-containing compound [inference]

cellular response to cGMP

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cGMP

cellular response to organonitrogen compound [inference]

cellular response to cGMP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cGMP

cellular response to oxygen-containing compound [inference]

cellular response to cGMP

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of ribonuclease activity

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of ribonuclease activity

regulation of macromolecule metabolic process [inference]

regulation of nuclease activity [inference]

regulation of ribonuclease activity

regulation of RNA metabolic process [inference]

regulation of ribonuclease activity

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of ribonuclease activity

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of cAMP-mediated signaling [inference]

negative regulation of cAMP-mediated signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of oocyte development

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of oocyte development

positive regulation of reproductive process [inference]

positive regulation of oocyte development

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of cAMP-mediated signaling [inference]

negative regulation of cAMP-mediated signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of oocyte development

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of oocyte development

regulation of oogenesis [inference]

regulation of oocyte development [inference]

positive regulation of oocyte development

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of oocyte development

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

hormone-mediated signaling pathway [inference]

steroid hormone mediated signaling pathway [inference]

intracellular steroid hormone receptor signaling pathway

intracellular receptor signaling pathway [inference]

intracellular steroid hormone receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

cyclic-nucleotide-mediated signaling [inference]

apoptotic signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of cAMP-mediated signaling [inference]

negative regulation of cAMP-mediated signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of ribonuclease activity

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of oocyte development

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of oocyte development

regulation of oogenesis [inference]

regulation of oocyte development [inference]

positive regulation of oocyte development

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of oocyte development

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of nuclear division [inference]

regulation of meiotic nuclear division

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of meiotic nuclear division

regulation of meiotic cell cycle [inference]

regulation of meiotic nuclear division

regulation of multicellular organismal process [inference]

regulation of oogenesis [inference]

regulation of oocyte development [inference]

positive regulation of oocyte development

regulation of reproductive process [inference]

regulation of meiotic cell cycle [inference]

regulation of meiotic nuclear division

regulation of oogenesis [inference]

regulation of oocyte development [inference]

positive regulation of oocyte development

positive regulation of reproductive process [inference]

positive regulation of oocyte development

regulation of biological quality [inference]

regulation of vascular permeability [inference]

regulation of molecular function [inference]

regulation of catalytic activity [inference]

regulation of hydrolase activity [inference]

regulation of nuclease activity [inference]

regulation of ribonuclease activity

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytosol	TAS
cytosol	IDA	35104454
cytosol	IBA
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
3',5'-cyclic-nucleotide phosphodiesterase activity	IDA	27975297
3',5'-cyclic-AMP phosphodiesterase activity	TAS
3',5'-cyclic-AMP phosphodiesterase activity	IDA	8155697
3',5'-cyclic-AMP phosphodiesterase activity	IBA
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

cyclic-nucleotide phosphodiesterase activity [inference]

3',5'-cyclic-nucleotide phosphodiesterase activity

binding [inference]

protein binding

hormone binding [inference]

estrogen binding

ion binding [inference]

cation binding [inference]

metal ion binding

molecular transducer activity [inference]

signaling receptor activity [inference]

nuclear steroid receptor activity [inference]

nuclear estrogen receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Phosphodiesterase

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
3',5'-cyclic-nucleotide phosphodiesterase activity
hydrolase activity
metal ion binding

Displaying **all 4** entries
InterPro
3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
3'5'-cyclic nucleotide phosphodiesterase, conserved site
HD/PDEase domain

Human Protein Atlas

ENSG00000172572

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:14653

H₂O + a nucleoside 3',5'-cyclic phosphate

H⁺ + a nucleoside 5'-phosphate

Enzyme

3.1.4.17

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111247	hypertension and brachydactyly syndrome	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying **all 8** entries
HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000822	Hypertension
HP:0001156	Brachydactyly
HP:0004322	Short stature
HP:0005863	Type E brachydactyly
HP:0009803	Short phalanx of finger
HP:0010049	Short metacarpal
HP:0010579	Cone-shaped epiphysis

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:1276	brachydactyly-arterial hypertension syndrome
OMIM:112410	brachydactyly-arterial hypertension syndrome

PubChem Disease

MedGen Diseases

Brachydactyly-arterial hypertension syndrome

OMIM Phenotypes

HYPERTENSION AND BRACHYDACTYLY SYNDROME; HTNB

KEGG Diseases

Brachydactyly

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 63 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	5139	ZFIN:ZDB-GENE-041210-23
Caenorhabditis elegans	5140	WB:WBGene00008443
Rattus norvegicus	50678		RATNO31337
Mus musculus	54611		MOUSE50167
Pan troglodytes	465329		PANTR05328
Danio rerio	567051		DANRE34227
Macaca mulatta	704524		MACMU03271
Oryctolagus cuniculus	100009330		RABIT12202
Monodelphis domestica	100011746		MONDO33096
Equus caballus	100034086		HORSE35910

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

PubChem Disease

International Collaboration

Acknowledgements