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phospholipase C beta 3

Summary

Gene Symbol

PLCB3

Organism

Homo sapiens (human)

External Links

NCBI Gene

5331

HGNC

9056

KEGG Gene ID

hsa:5331

PubChem

5331

Alliance of Genome Resources

HGNC:9056

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Calcium
Cytoplasm
Dwarfism
Hydrolase
Lipid degradation
Membrane
Nucleus
Phosphoprotein
Reference proteome
Transducer

Proteins

Displaying 1 entry
UniProt	Protein Name
Q01970	Phosphoinositide phospholipase C-beta-3 Phospholipase C-beta-3

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
phosphatidylinositol-mediated signaling	IBA
regulation of systemic arterial blood pressure	IDA	18468998
release of sequestered calcium ion into cytosol	IBA
phospholipase C-activating serotonin receptor signaling pathway	IDA	20966218
phospholipase C-activating G protein-coupled receptor signaling pathway	IDA ISS	20966218 37991948

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

organic substance catabolic process [inference]

lipid catabolic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organic substance catabolic process [inference]

lipid catabolic process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway [inference]

phospholipase C-activating serotonin receptor signaling pathway

intracellular signal transduction [inference]

phosphatidylinositol-mediated signaling

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway [inference]

phospholipase C-activating serotonin receptor signaling pathway

intracellular signal transduction [inference]

phosphatidylinositol-mediated signaling

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of biological quality [inference]

regulation of blood pressure [inference]

regulation of systemic arterial blood pressure

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GO Term	Evidence Code	PMID
membrane	IEA
protein-containing complex	IDA	18468998
postsynaptic cytosol	IEA
nucleus	IEA
cytosol	TAS

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

cytoplasm

cytosol

cytosolic region [inference]

postsynaptic cytosol

membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

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GO Term	Evidence Code	PMID
protein binding	IPI	21822282 23377541
phospholipase C activity	TAS
calmodulin binding	IBA IDA	12821674
molecular function activator activity	EXP	23377541
phosphatidylinositol phospholipase C activity	IBA IDA	20966218 37991948 9188725

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

phospholipase C activity

phosphatidylinositol phospholipase C activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

phospholipase C activity

phosphatidylinositol phospholipase C activity

binding [inference]

protein binding

calmodulin binding

cell adhesion molecule binding [inference]

cadherin binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular adaptor activity

molecular function regulator activity [inference]

molecular function activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
hydrolase activity
lipid metabolic process
phosphatidylinositol phospholipase C activity
phosphatidylinositol-mediated signaling
release of sequestered calcium ion into cytosol

Displaying **all 7** entries
InterPro
C2 domain superfamily
C2 domain
EF-hand domain pair
PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
Phosphatidylinositol-specific phospholipase C, X domain
Phosphoinositide phospholipase C family
Phospholipase C, phosphatidylinositol-specific, Y domain

KEGG BRITE Database

Orthology

K05858

Name

phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]

References

Rhea

RHEA:33179

H₂O + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)

H⁺ + a 1,2-diacyl-sn-glycerol + 1D-myo-inositol 1,4,5-trisphosphate

Enzyme

3.1.4.11

PMID

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0112303	spondylometaphyseal dysplasia with corneal dystrophy	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **11 - 20** of 23 in total

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HPO ID	HPO Term
HP:0003016	Metaphyseal widening
HP:0003026	Short long bone
HP:0003177	Squared iliac bones
HP:0003196	Short nose
HP:0003819	Death in childhood
HP:0004568	Beaking of vertebral bodies
HP:0004592	Thoracic platyspondyly
HP:0005280	Depressed nasal bridge
HP:0005787	Lumbar platyspondyly
HP:0007957	Corneal opacity

Displaying 1 entry
Disease ID	Disease Name
OMIM:618961	spondylometaphyseal dysplasia with corneal dystrophy

PubChem Disease

MedGen Diseases

Spondylometaphyseal dysplasia with corneal dystrophy

OMIM Phenotypes

SPONDYLOMETAPHYSEAL DYSPLASIA WITH CORNEAL DYSTROPHY; SMDCD

KEGG Diseases

Spondylometaphyseal dysplasia

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002106
Gene Name: phospholipase C, beta 3 (phosphatidylinositol-specific)

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	18797		MGI:104778	MOUSE27073
Rattus norvegicus	29322		RGD:61993	RATNO20578
Drosophila melanogaster	33204		FB:FBgn0004611
Xenopus laevis	397692		Xenbase:XB-GENE-1008416
Pan troglodytes	451290	9598_0:002f73		PANTR03275
Canis lupus familiaris	476034			CANLF06104
Saccharomyces cerevisiae S288C	855860		SGD:S000006189
Danio rerio	100001532		ZFIN:ZDB-GENE-030616-594	DANRE40980
Equus caballus	100055407			HORSE05170
Ornithorhynchus anatinus	100081349			ORNAN18908

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements