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UDP glucuronosyltransferase family 1 member A7

Summary

Gene Symbol

UGT1A7

Aliases

UGT1G

Organism

Homo sapiens (human)

External Links

NCBI Gene

54577

HGNC

12539

KEGG Gene ID

hsa:54577

PubChem

54577

Alliance of Genome Resources

HGNC:12539

Annotation

Keyword

Alternative splicing
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Lipid metabolism
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9HAW7	UDP-glucuronosyltransferase 1-7 UDP-glucuronosyltransferase 1-G
Q5DSZ7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 13** of 13 in total

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GO Term	Evidence Code	PMID
xenobiotic metabolic process	IC	19996319
coumarin metabolic process	IC	19996319
estrogen metabolic process	IDA	18719240

GO Hierarchy

biological process

metabolic process [inference]

secondary metabolic process [inference]

phenylpropanoid metabolic process [inference]

coumarin metabolic process

pigment metabolic process [inference]

flavone metabolic process

hormone metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

cellular glucuronidation

cellular aromatic compound metabolic process [inference]

phenylpropanoid metabolic process [inference]

coumarin metabolic process

xenobiotic metabolic process

xenobiotic glucuronidation

cellular lipid metabolic process [inference]

fatty acid metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinoic acid metabolic process

heterocycle metabolic process [inference]

coumarin metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

estrogen metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinoic acid metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

cellular glucuronidation

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

cellular glucuronidation

lipid metabolic process [inference]

steroid metabolic process [inference]

estrogen metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinoic acid metabolic process

flavonoid metabolic process [inference]

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

estrogen metabolic process

phenylpropanoid metabolic process [inference]

coumarin metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

cellular glucuronidation

cellular aromatic compound metabolic process [inference]

phenylpropanoid metabolic process [inference]

coumarin metabolic process

xenobiotic metabolic process

xenobiotic glucuronidation

cellular lipid metabolic process [inference]

fatty acid metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinoic acid metabolic process

heterocycle metabolic process [inference]

coumarin metabolic process

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

gland development [inference]

liver development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process

negative regulation of carbohydrate metabolic process [inference]

negative regulation of cellular glucuronidation

negative regulation of small molecule metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid metabolic process

regulation of cellular glucuronidation [inference]

negative regulation of cellular glucuronidation

negative regulation of cellular metabolic process [inference]

regulation of small molecule metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid metabolic process

regulation of cellular glucuronidation [inference]

negative regulation of cellular glucuronidation

negative regulation of small molecule metabolic process [inference]

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

negative regulation of carbohydrate metabolic process [inference]

negative regulation of cellular glucuronidation

regulation of cellular glucuronidation [inference]

negative regulation of cellular glucuronidation

regulation of lipid metabolic process [inference]

regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid metabolic process

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process

negative regulation of carbohydrate metabolic process [inference]

negative regulation of cellular glucuronidation

negative regulation of small molecule metabolic process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid metabolic process

regulation of cellular glucuronidation [inference]

negative regulation of cellular glucuronidation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of transferase activity [inference]

negative regulation of glucuronosyltransferase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of transferase activity [inference]

negative regulation of glucuronosyltransferase activity

regulation of transferase activity [inference]

negative regulation of transferase activity [inference]

negative regulation of glucuronosyltransferase activity

regulation of glucuronosyltransferase activity [inference]

negative regulation of glucuronosyltransferase activity

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IBA IDA	17179145 18556656
endoplasmic reticulum membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
protein heterodimerization activity	IEA
glucuronosyltransferase activity	IDA	17179145 18052087 18719240 19996319 20056724 20308471

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

glucuronosyltransferase activity

hexosyltransferase activity [inference]

glucuronosyltransferase activity

binding [inference]

protein binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein kinase C binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

lipid binding [inference]

isoprenoid binding [inference]

retinoid binding [inference]

retinoic acid binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

retinoic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

retinoic acid binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00699

Name

glucuronosyltransferase [EC:2.4.1.17]

References

Rhea

glucuronate acceptor + UDP-α-D-glucuronate

acceptor β-D-glucuronoside + H⁺ + UDP

Enzyme

2.4.1.17

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of **101** in total

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DO ID	Disease Name	Source
DOID:10286	prostate carcinoma	DisGeNET DisGeNET
DOID:0050589	inflammatory bowel disease	DisGeNET DisGeNET
DOID:0050590	severe congenital neutropenia	DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0060192	Crohn's colitis	DisGeNET
DOID:0060262	gallbladder disease	DisGeNET
DOID:0060319	cardiac arrest	DisGeNET
DOID:0070322	childhood hepatocellular carcinoma	DisGeNET
DOID:0070328	adult hepatocellular carcinoma	DisGeNET
DOID:0080199	colorectal carcinoma	DisGeNET

Ortholog

Displaying entries **41 - 50** of 50 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Rattus norvegicus	113992		RATNO42391
Rattus norvegicus	154516	RGD:620950	RATNO42391
Rattus norvegicus	301595	RGD:708474	RATNO42391
Rattus norvegicus	396527		RATNO42391
Rattus norvegicus	396551		RATNO42391
Rattus norvegicus	574523		RATNO42391
Chinchilla lanigera	102006309		CHILA13882
Jaculus jaculus	101617823		JACJA13787
Saccharomyces cerevisiae S288C	850886	SGD:S000004179
Cyprinus carpio carpio	109096697		CYPCA51496

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Last updated: August 19, 2024