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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
protein kinase AMP-activated catalytic subunit alpha 1
Summary
- Gene Symbol
-
- PRKAA1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Autophagy
- Biological rhythms
- Cholesterol biosynthesis
- Chromatin regulator
- Cytoplasm
- Fatty acid biosynthesis
- Glycoprotein
- Host-virus interaction
- Magnesium
- Metal-binding
- Nucleus
- Phosphoprotein
- Reference proteome
- Serine/threonine-protein kinase
- Transcription regulation
- Ubl conjugation
- Wnt signaling pathway
- Proteins
| UniProt | Protein Name |
|---|---|
| Q13131 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of cell population proliferation | ||
| autophagy | ||
| fatty acid biosynthetic process | ||
| cellular response to prostaglandin E stimulus | ||
| positive regulation of adipose tissue development |
GO Hierarchy
- rhythmic process
- response to activity
- regulation of circadian rhythm
- regulation of vesicle-mediated transport
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
response to chemical [inference]
cellular response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of small molecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of cellular component biogenesis [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cellular localization [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| nucleotide-activated protein kinase complex | ||
| nuclear speck | ||
| apical plasma membrane | ||
| neuronal cell body | ||
| nucleoplasm |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity | ||
| protein binding | ||
| protein serine kinase activity | ||
| histone H2BS36 kinase activity | ||
| protein-containing complex binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- kinase
- Functional Category
-
- E: Amino acid transport and metabolism
- K: Transcription
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| kinase activity |
| nucleotide binding |
| phosphorylation |
| InterPro |
|---|
| Protein kinase domain |
| Protein kinase, ATP binding site |
| Protein kinase-like domain superfamily |
| Serine/threonine-protein kinase, active site |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:12858 | Huntington's disease | |
| DOID:13580 | cholestasis | |
| DOID:14330 | Parkinson's disease | |
| DOID:1612 | breast cancer | |
| DOID:219 | colon cancer | |
| DOID:3908 | lung non-small cell carcinoma | |
| DOID:9352 | type 2 diabetes mellitus | |
| DOID:9970 | obesity |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 102349521 | LATCH02452 | |||
| 102444277 | PELSI17484 | |||
| 103022500 | ASTMX11189 | |||
| 103664677 | URSMA02533 | |||
| 103741338 | NANGA03564 | |||
| 106562970 | SALSA13405 | |||
| 106568674 | SALSA68388 | |||
| 107597029 | SINGR12014 | |||
| 108260283 | ICTPU23023 | |||
| 109061980 | CYPCA16323 |
