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Guidelines

MIRAGE

CF transmembrane conductance regulator

Summary

Gene Symbol

cftr

Organism

Danio rerio (zebrafish)

External Links

NCBI Gene

559080

PubChem

559080

Alliance of Genome Resources

ZFIN:ZDB-GENE-050517-20

Annotation

Keyword

3D-structure
ATP-binding
Cell membrane
Chloride channel
Endoplasmic reticulum
Endosome
Glycoprotein
Isomerase
Phosphoprotein
Reference proteome
Repeat
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q1LX78	ATP-binding cassette sub-family C member 7 Channel conductance-controlling ATPase cAMP-dependent chloride channel

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
respiratory burst involved in defense response	IMP	20732993
ion transport	IEA
monoatomic ion transport	IEA
chloride transport	IEA
heart development	IMP	32574800

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

respiratory burst involved in defense response

immune response [inference]

innate immune response

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation

T cell activation [inference]

T cell differentiation

metabolic process [inference]

respiratory burst [inference]

respiratory burst involved in defense response

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation

T cell activation [inference]

T cell differentiation

cellular process involved in reproduction in multicellular organism [inference]

germ cell migration

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation

cell development [inference]

hemopoiesis [inference]

embryonic hemopoiesis

cell motility [inference]

cell migration [inference]

germ cell migration

lymphoid lineage cell migration [inference]

lymphoid lineage cell migration into thymus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to forskolin

cellular response to organic cyclic compound [inference]

cellular response to forskolin

cellular response to alcohol [inference]

cellular response to forskolin

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to forskolin

cellular response to ketone [inference]

cellular response to forskolin

transmembrane transport

monoatomic ion transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

reproductive process [inference]

cellular process involved in reproduction in multicellular organism [inference]

germ cell migration

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation

T cell activation [inference]

T cell differentiation

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

Spemann organizer formation [inference]

Spemann organizer formation at the embryonic shield

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

embryonic hemopoiesis

animal organ development [inference]

embryonic organ development [inference]

embryonic hemopoiesis

Kupffer's vesicle development

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation

cell development [inference]

hemopoiesis [inference]

embryonic hemopoiesis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

chemical homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

response to chemical [inference]

response to organic substance [inference]

response to organic cyclic compound [inference]

cellular response to organic cyclic compound [inference]

cellular response to forskolin

response to forskolin [inference]

cellular response to forskolin

response to lipid [inference]

cellular response to lipid [inference]

cellular response to forskolin

response to forskolin [inference]

cellular response to forskolin

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to forskolin

cellular response to organic cyclic compound [inference]

cellular response to forskolin

cellular response to alcohol [inference]

cellular response to forskolin

response to alcohol [inference]

cellular response to alcohol [inference]

cellular response to forskolin

response to forskolin [inference]

cellular response to forskolin

response to ketone [inference]

cellular response to ketone [inference]

cellular response to forskolin

response to forskolin [inference]

cellular response to forskolin

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to forskolin

cellular response to organic cyclic compound [inference]

cellular response to forskolin

cellular response to alcohol [inference]

cellular response to forskolin

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to forskolin

cellular response to ketone [inference]

cellular response to forskolin

response to oxygen-containing compound [inference]

response to alcohol [inference]

cellular response to alcohol [inference]

cellular response to forskolin

response to forskolin [inference]

cellular response to forskolin

response to ketone [inference]

cellular response to ketone [inference]

cellular response to forskolin

response to forskolin [inference]

cellular response to forskolin

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to forskolin

cellular response to ketone [inference]

cellular response to forskolin

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to forskolin

cellular response to organic cyclic compound [inference]

cellular response to forskolin

cellular response to alcohol [inference]

cellular response to forskolin

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to forskolin

cellular response to ketone [inference]

cellular response to forskolin

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic anion transport [inference]

chloride transport

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

fluid transport [inference]

water transport [inference]

transepithelial water transport

epithelial fluid transport [inference]

transepithelial water transport

transmembrane transport

monoatomic ion transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transepithelial transport [inference]

epithelial fluid transport [inference]

transepithelial water transport

organic substance transport [inference]

water transport [inference]

transepithelial water transport

organic anion transport [inference]

bicarbonate transport

one-carbon compound transport [inference]

bicarbonate transport

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of leukocyte migration [inference]

regulation of leukocyte chemotaxis [inference]

regulation of granulocyte chemotaxis [inference]

regulation of neutrophil chemotaxis

regulation of neutrophil migration [inference]

regulation of neutrophil chemotaxis

regulation of locomotion [inference]

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

regulation of granulocyte chemotaxis [inference]

regulation of neutrophil chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

regulation of leukocyte chemotaxis [inference]

regulation of granulocyte chemotaxis [inference]

regulation of neutrophil chemotaxis

regulation of neutrophil migration [inference]

regulation of neutrophil chemotaxis

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

regulation of granulocyte chemotaxis [inference]

regulation of neutrophil chemotaxis

regulation of cellular process [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

regulation of leukocyte chemotaxis [inference]

regulation of granulocyte chemotaxis [inference]

regulation of neutrophil chemotaxis

regulation of neutrophil migration [inference]

regulation of neutrophil chemotaxis

regulation of biological quality [inference]

regulation of body fluid levels [inference]

multicellular organismal-level water homeostasis

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
endosome	IEA
endoplasmic reticulum	IEA
endoplasmic reticulum membrane	ISS
cytosol	IBA
plasma membrane	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

chloride channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

chloride channel complex

cellular anatomical entity [inference]

cytosol

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

bounding membrane of organelle [inference]

endosome membrane [inference]

plasma membrane region [inference]

apical plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
nucleotide binding	IEA
DNA clamp loader activity	IEA
chloride channel activity	ISS
chloride channel activity	IDA	32123813
chloride channel activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

isomerase activity

catalytic activity, acting on a protein [inference]

ATP-dependent histone chaperone activity [inference]

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA [inference]

DNA clamp loader activity

DNA translocase activity [inference]

chromatin extrusion motor activity

ATP-dependent chromatin remodeler activity [inference]

ATP-dependent histone chaperone activity [inference]

cohesin loader activity

transporter activity [inference]

transmembrane transporter activity [inference]

organic anion transmembrane transporter activity [inference]

bicarbonate transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

intracellularly ATP-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

intracellularly ATP-gated chloride channel activity

ligand-gated monoatomic ion channel activity [inference]

intracellular ligand-gated monoatomic ion channel activity [inference]

intracellularly ATP-gated ion channel activity [inference]

intracellularly ATP-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

intracellularly ATP-gated chloride channel activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

intracellularly ATP-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

intracellularly ATP-gated chloride channel activity

chloride transmembrane transporter activity [inference]

chloride channel activity

intracellularly ATP-gated chloride channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

intracellularly ATP-gated chloride channel activity

bicarbonate transmembrane transporter activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

intracellularly ATP-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

intracellularly ATP-gated chloride channel activity

ligand-gated monoatomic ion channel activity [inference]

intracellular ligand-gated monoatomic ion channel activity [inference]

intracellularly ATP-gated ion channel activity [inference]

intracellularly ATP-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

intracellularly ATP-gated chloride channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

intracellular ligand-gated monoatomic ion channel activity [inference]

intracellularly ATP-gated ion channel activity [inference]

intracellularly ATP-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

intracellularly ATP-gated chloride channel activity

ATP-gated ion channel activity [inference]

intracellularly ATP-gated ion channel activity [inference]

intracellularly ATP-gated chloride channel activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

salt transmembrane transporter activity [inference]

bicarbonate transmembrane transporter activity

chloride transmembrane transporter activity [inference]

chloride channel activity

intracellularly ATP-gated chloride channel activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular carrier activity [inference]

protein carrier chaperone [inference]

histone chaperone activity [inference]

H3-H4 histone complex chaperone activity [inference]

ATP-dependent H3-H4 histone complex chaperone activity

ATP-dependent histone chaperone activity [inference]

ATP-dependent activity [inference]

ATP-dependent activity, acting on DNA [inference]

DNA clamp loader activity

DNA translocase activity [inference]

chromatin extrusion motor activity

ATP-dependent chromatin remodeler activity [inference]

ATP-dependent histone chaperone activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ABC

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter type 1, transmembrane domain superfamily
ABC transporter type 1, transmembrane domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
P-loop containing nucleoside triphosphate hydrolase

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
apical plasma membrane	PMID:20933420
microvillus	PMID:20933420

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:1485	cystic fibrosis	Alliance of Genome Resources
DOID:9351	diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **81 - 88** of 88 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Strigops habroptila	115604828		STRHB21656
Corvus moneduloides	116443361		CORMO20241
Chelonoidis abingdonii	116838613		CHEAB18936
Rhinolophus ferrumequinum	117018340		RHIFE12116
Scophthalmus maximus	118314811		SCOMX00016
Balaenoptera musculus	118901296		BALMU12161
Panthera leo	122210280		PANLE21954
Ursus americanus	123789030		URSAM00018

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Last updated: April 7, 2025