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specc1la sperm antigen with calponin homology and coiled-coil domains 1-like a [ Danio rerio (zebrafish) ]

Gene ID: 561775, updated on 9-Dec-2024

Summary

Official Symbol
specc1laprovided by ZNC
Official Full Name
sperm antigen with calponin homology and coiled-coil domains 1-like aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060810-139
See related
Ensembl:ENSDARG00000006719 AllianceGenome:ZFIN:ZDB-GENE-060810-139
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cytsaa; specc1l; im:7159316
Summary
Acts upstream of or within face morphogenesis. Predicted to be located in cytoplasm; gap junction; and spindle. Predicted to be part of filamentous actin. Predicted to be active in microtubule organizing center. Human ortholog(s) of this gene implicated in Teebi hypertelorism syndrome 1 and oblique facial clefting 1. Orthologous to human SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1 like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See specc1la in Genome Data Viewer
Location:
chromosome: 8
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (30600514..30662945)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (30591254..30653728)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene phosphoglucomutase 5 Neighboring gene si:dkey-91m11.5 Neighboring gene adenosine A2a receptor a Neighboring gene chromosome 8 C22orf15 homolog

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in actin cytoskeleton organization  
acts_upstream_of_or_within cell division  
involved_in cell division  
acts_upstream_of_or_within face morphogenesis PubMed 
Component Evidence Code Pubs
located_in anchoring junction  
located_in cytoplasm  
located_in cytoskeleton  
part_of filamentous actin  
located_in gap junction  
is_active_in microtubule organizing center  
located_in spindle  

General protein information

Preferred Names
cytospin-A
Names
SPECC1-like protein
cytospin A, genome duplicate a
cytospin-A-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039816.1NP_001034905.1  cytospin-A

    See identical proteins and their annotated locations for NP_001034905.1

    Status: PROVISIONAL

    Source sequence(s)
    AY884302
    UniProtKB/TrEMBL
    A0A286YBD4
    Related
    ENSDARP00000010292.6, ENSDART00000014046.8
    Conserved Domains (3) summary
    cd00014
    Location:10301130
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam14988
    Location:595791
    DUF4515; Domain of unknown function (DUF4515)
    cl02488
    Location:608793
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    30600514..30662945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167177.5XP_005167234.1  cytospin-A isoform X1

    See identical proteins and their annotated locations for XP_005167234.1

    UniProtKB/Swiss-Prot
    B0UYP9, Q2KN93
    Related
    ENSDARP00000135296.1, ENSDART00000164976.2
    Conserved Domains (3) summary
    cd00014
    Location:10301130
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam14988
    Location:595791
    DUF4515; Domain of unknown function (DUF4515)
    cl02488
    Location:608793
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  2. XM_009304055.4XP_009302330.1  cytospin-A isoform X2

    UniProtKB/TrEMBL
    A0A8M3AV87
    Conserved Domains (2) summary
    pfam14988
    Location:595791
    DUF4515; Domain of unknown function (DUF4515)
    cl02488
    Location:608793
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394731.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    227485..261608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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