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prss12 serine protease 12 [ Danio rerio (zebrafish) ]

Gene ID: 566809, updated on 4-Jan-2025

Summary

Official Symbol
prss12provided by ZNC
Official Full Name
serine protease 12provided by ZNC
Primary source
ZFIN:ZDB-GENE-090313-45
See related
Ensembl:ENSDARG00000061830 AllianceGenome:ZFIN:ZDB-GENE-090313-45
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-152j23.2
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Is expressed in hypural. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 1 and intellectual disability. Orthologous to human PRSS12 (serine protease 12). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See prss12 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (20069065..20142317)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (19375927..19446084)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene putative methyltransferase NSUN7 Neighboring gene uncharacterized LOC137495487 Neighboring gene methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit Neighboring gene N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 Neighboring gene UDP glycosyltransferase 8

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity  
enables peptidase activity  
enables serine-type endopeptidase activity  
enables serine-type peptidase activity  
Component Evidence Code Pubs
located_in membrane  

General protein information

Preferred Names
neurotrypsin
Names
protease, serine, 12 (neurotrypsin, motopsin)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    20069065..20142317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001920264.6XP_001920299.3  neurotrypsin isoform X1

    UniProtKB/TrEMBL
    A0A8M1QHD3
    Related
    ENSDARP00000083086.4, ENSDART00000088653.4
    Conserved Domains (5) summary
    smart00020
    Location:567812
    Tryp_SPc; Trypsin-like serine protease
    smart00202
    Location:218317
    SR; Scavenger receptor Cys-rich
    cd00190
    Location:568815
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00530
    Location:223317
    SRCR; Scavenger receptor cysteine-rich domain
    cl00100
    Location:28105
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394475.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    252102..325543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021471174.2XP_021326849.1  neurotrypsin isoform X1

    UniProtKB/TrEMBL
    A0A8M9PPR7
    Conserved Domains (4) summary
    smart00202
    Location:218317
    SR; Scavenger receptor Cys-rich
    cd00190
    Location:568815
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00530
    Location:113207
    SRCR; Scavenger receptor cysteine-rich domain
    cl00100
    Location:28105
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395210.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    9775..67697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021473890.2XP_021329565.1  neurotrypsin isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q8F7
    Conserved Domains (3) summary
    smart00202
    Location:60159
    SR; Scavenger receptor Cys-rich
    cd00190
    Location:410657
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00530
    Location:1249
    SRCR; Scavenger receptor cysteine-rich domain
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