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surfactant protein C

Summary

Gene Symbol

SFTPC

Aliases

BRICD6
BRICHOS domain containing 6
PSP-C
SMDP2
SP-C

Organism

Homo sapiens (human)

External Links

NCBI Gene

6440

HGNC

10802

KEGG Gene ID

hsa:6440

PubChem

6440

Alliance of Genome Resources

HGNC:10802

Annotation

Keyword

3D-structure
Alternative splicing
Direct protein sequencing
Disease variant
Disulfide bond
Palmitate
Proteomics identification
Reference proteome
Surface film
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P11686	Pulmonary surfactant-associated protein C Pulmonary surfactant-associated proteolipid SPL(Val) SP5
A0A0S2Z4Q0	Pulmonary surfactant-associated protein C Pulmonary surfactant-associated proteolipid SPL(Val)
E5RI64	Pulmonary surfactant-associated protein C

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
respiratory gaseous exchange by respiratory system	IEA

GO Hierarchy

biological process

multicellular organismal process [inference]

respiratory gaseous exchange by respiratory system

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
alveolar lamellar body	IBA
multivesicular body lumen
lamellar body
extracellular region
endoplasmic reticulum membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endosome lumen [inference]

late endosome lumen [inference]

multivesicular body lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

secretory vesicle [inference]

secretory granule [inference]

lamellar body

alveolar lamellar body

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

secretory vesicle [inference]

secretory granule [inference]

lamellar body

alveolar lamellar body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

secretory vesicle [inference]

secretory granule [inference]

lamellar body

alveolar lamellar body

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	19815549 25416956 25910212 26871637 31515488 32296183
identical protein binding	IPI	25416956 25910212 31515488 32296183

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000168484

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K26068

Name

pulmonary surfactant-associated protein C

References

3035561

Disease

Disease Ontology

Displaying entries **21 - 30** of 93 in total

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DO ID	Disease Name	Source
DOID:10393	secondary hypertrophic osteoarthropathy	DisGeNET
DOID:10652	Alzheimer's disease	DisGeNET DisGeNET
DOID:10763	hypertension	DisGeNET
DOID:10825	essential hypertension	DisGeNET
DOID:10908	hydrocephalus	DisGeNET
DOID:11161	neonatal respiratory failure	DisGeNET
DOID:11394	adult respiratory distress syndrome	DisGeNET DisGeNET DisGeNET DisGeNET Alliance of Genome Resources
DOID:11612	polycystic ovary syndrome	DisGeNET DisGeNET
DOID:11714	gestational diabetes	DisGeNET
DOID:11870	Pick's disease	DisGeNET

The Human Phenotype Ontology

Displaying entries **21 - 30** of 42 in total

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HPO ID	HPO Term
HP:0002206	Pulmonary fibrosis
HP:0002615	Hypotension
HP:0002789	Tachypnea
HP:0002875	Exertional dyspnea
HP:0002878	Respiratory failure
HP:0003546	Exercise intolerance
HP:0005942	Desquamative interstitial pneumonitis
HP:0006515	Interstitial pneumonitis
HP:0006517	Intraalveolar phospholipid accumulation
HP:0006519	Alveolar cell carcinoma

Displaying **all 4** entries
Disease ID	Disease Name
OMIM:610913	surfactant metabolism dysfunction, pulmonary, 2
ORPHA:70587	respiratory distress syndrome in premature infants
OMIM:178500	interstitial lung disease 2
ORPHA:2032	interstitial lung disease 2

PubChem Disease

GHR Health Conditions

MedGen Diseases

OMIM Phenotypes

SURFACTANT METABOLISM DYSFUNCTION, PULMONARY, 2; SMDP2

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **51 - 53** of 53 in total

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Species	Gene ID	Orthologous MAtrix
Propithecus coquereli	105825229	PROCO10347
Carlito syrichta	103265901	CARSF00806
Strigops habroptila	115618558	STRHB19716

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements