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steroid 5 alpha-reductase 2

Summary

Gene Symbol

SRD5A2

Aliases

3-oxo-5-alpha-steroid 4-dehydrogenase 2

Organism

Homo sapiens (human)

External Links

NCBI Gene

6716

HGNC

11285

KEGG Gene ID

hsa:6716

PubChem

6716

Alliance of Genome Resources

HGNC:11285

Annotation

Keyword

3D-structure
Disease variant
Lipid metabolism
Microsome
NADP
Oxidoreductase
Pseudohermaphroditism
Reference proteome
Sexual differentiation
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P31213	5 alpha-SR2 SR type 2 Steroid 5-alpha-reductase 2 Type II 5-alpha reductase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
dibenzo-p-dioxin metabolic process	IEA
hippocampus development	IEA
response to xenobiotic stimulus	IEA
response to follicle-stimulating hormone	IEA
hypothalamus development	IEA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process

biosynthetic process [inference]

hormone biosynthetic process [inference]

androgen biosynthetic process

cellular biosynthetic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

small molecule biosynthetic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

ketone biosynthetic process [inference]

testosterone biosynthetic process

olefinic compound biosynthetic process [inference]

testosterone biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

organic hydroxy compound biosynthetic process [inference]

testosterone biosynthetic process

hormone metabolic process [inference]

androgen metabolic process

androgen biosynthetic process

hormone biosynthetic process [inference]

androgen biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

phthalate metabolic process

cellular aromatic compound metabolic process [inference]

dibenzo-p-dioxin metabolic process

benzene-containing compound metabolic process [inference]

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

cellular biosynthetic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

heterocycle metabolic process [inference]

dibenzo-p-dioxin metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

steroid catabolic process

androgen metabolic process

androgen biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

lipid catabolic process [inference]

steroid catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

phthalate metabolic process

dibenzo-p-dioxin metabolic process

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

small molecule biosynthetic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

phthalate metabolic process

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

steroid catabolic process

androgen metabolic process

androgen biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

lipid catabolic process [inference]

steroid catabolic process

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

olefinic compound metabolic process [inference]

olefinic compound biosynthetic process [inference]

testosterone biosynthetic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

steroid catabolic process

androgen metabolic process

androgen biosynthetic process

dibenzo-p-dioxin metabolic process

benzene-containing compound metabolic process [inference]

organic cyclic compound catabolic process [inference]

steroid catabolic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

ketone biosynthetic process [inference]

testosterone biosynthetic process

olefinic compound biosynthetic process [inference]

testosterone biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

organic hydroxy compound biosynthetic process [inference]

testosterone biosynthetic process

organic hydroxy compound metabolic process [inference]

organic hydroxy compound biosynthetic process [inference]

testosterone biosynthetic process

cellular process [inference]

cell communication [inference]

cell-cell signaling

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

phthalate metabolic process

cellular aromatic compound metabolic process [inference]

dibenzo-p-dioxin metabolic process

benzene-containing compound metabolic process [inference]

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

cellular biosynthetic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

heterocycle metabolic process [inference]

dibenzo-p-dioxin metabolic process

cellular developmental process [inference]

cell differentiation

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

genitalia development [inference]

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

genitalia development [inference]

anatomical structure development [inference]

animal organ development [inference]

gonad development [inference]

male gonad development

genitalia development [inference]

bone development

reproductive structure development [inference]

gonad development [inference]

male gonad development

genitalia development [inference]

system development [inference]

reproductive system development [inference]

male genitalia development

cellular developmental process [inference]

cell differentiation

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels

response to endogenous stimulus [inference]

response to hormone [inference]

response to gonadotropin [inference]

response to follicle-stimulating hormone

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to hormone [inference]

response to gonadotropin [inference]

response to follicle-stimulating hormone

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone

response to organic cyclic compound [inference]

response to lipid [inference]

response to ketone [inference]

response to testosterone

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone

response to ketone [inference]

response to testosterone

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

androgen metabolic process

androgen biosynthetic process

hormone biosynthetic process [inference]

androgen biosynthetic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane
neuronal cell body	IEA
cell body fiber	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

cell body fiber

cell body [inference]

neuronal cell body

Displaying **all 5** entries
GO Term	Evidence Code	PMID
3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)	IDA	1944596
protein binding	IPI	32296183 33961781
testosterone dehydrogenase [NAD(P)] activity	IDA	10898110
amide binding	IEA
3-oxo-5-alpha-steroid 4-dehydrogenase activity	IBA TAS

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

steroid dehydrogenase activity [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

testosterone dehydrogenase [NAD(P)] activity

steroid dehydrogenase activity, acting on the CH-CH group of donors [inference]

3-oxo-5-alpha-steroid 4-dehydrogenase activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

testosterone dehydrogenase [NAD(P)] activity

oxidoreductase activity, acting on the CH-CH group of donors [inference]

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [inference]

enone reductase activity [inference]

3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)

steroid dehydrogenase activity, acting on the CH-CH group of donors [inference]

3-oxo-5-alpha-steroid 4-dehydrogenase activity

binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

3-oxo-5-alpha-steroid 4-dehydrogenase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
3-oxo-5-alpha-steroid 4-dehydrogenase activity
brassinosteroid biosynthetic process
lipid metabolic process
oxidoreductase activity, acting on the CH-CH group of donors
oxidoreductase activity

Displaying **all 2** entries
InterPro
3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal
3-oxo-5-alpha-steroid 4-dehydrogenase/very-long-chain enoyl-CoA reductase

KEGG BRITE Database

Orthology

K12344

Name

3-oxo-5-alpha-steroid 4-dehydrogenase 2 [EC:1.3.1.22]

References

Rhea

RHEA:54384

a 3-oxo-5α-steroid + NADP⁺

H⁺ + a 3-oxo-Δ⁴-steroid + NADPH

Enzyme

1.3.1.22

PMID

RHEA:21952

5α-pregnane-3,20-dione + NADP⁺

H⁺ + progesterone + NADPH

Enzyme

1.3.1.22

PMID

RHEA:50820

17β-hydroxy-5α-androstan-3-one + NADP⁺

H⁺ + testosterone + NADPH

Enzyme

1.3.1.22

PMID

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:10283	prostate cancer	Alliance of Genome Resources
DOID:10892	hypospadias	Alliance of Genome Resources
DOID:12700	hyperprolactinemia	Alliance of Genome Resources
DOID:3459	breast carcinoma	Alliance of Genome Resources
DOID:9351	diabetes mellitus	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 15 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000028	Cryptorchidism
HP:0000033	Ambiguous genitalia, male
HP:0000046	Small scrotum
HP:0000048	Bifid scrotum
HP:0000051	Perineal hypospadias
HP:0000054	Micropenis
HP:0000062	Ambiguous genitalia
HP:0000144	Decreased fertility
HP:0000818	Abnormality of the endocrine system

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:264600	46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency
ORPHA:753	46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency

PubChem Disease

GHR Health Conditions

MedGen Diseases

3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency

OMIM Phenotypes

PSEUDOVAGINAL PERINEOSCROTAL HYPOSPADIAS; PPSH

KEGG Diseases

46,XY disorder of sex development due to testosterone secretion defect

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002521
Gene Name: steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)

Ortholog

Displaying entries **11 - 20** of 62 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Ornithorhynchus anatinus	100078235		ORNAN27915
Taeniopygia guttata	100225484		TAEGU21648
Oryctolagus cuniculus	100343882		RABIT08739
Pongo abelii	100454013	9601_0:000b33	PONAB23668
Ailuropoda melanoleuca	100466687		AILME04757
Nomascus leucogenys	100597634		NOMLE15760
Pan troglodytes	100614992	9598_0:000a4e	PANTR27359
Oreochromis niloticus	100694036		ORENI13183
Cavia porcellus	100731664		CAVPO09490
Ovis aries	100820756		SHEEP13958

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements