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MIRAGE
TNF alpha induced protein 3
Summary
- Gene Symbol
-
- TNFAIP3
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Apoptosis
- Cytoplasm
- DNA-binding
- Disease variant
- Inflammatory response
- Lysosome
- Multifunctional enzyme
- Nucleus
- Phosphoprotein
- Reference proteome
- Repeat
- Thiol protease
- Transferase
- Ubl conjugation pathway
- Zinc-finger
- Proteins
| UniProt | Protein Name |
|---|---|
| P21580 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| B-1 B cell homeostasis | ||
| response to molecule of bacterial origin | ||
| regulation of germinal center formation | ||
| negative regulation of chronic inflammatory response | ||
| apoptotic process |
GO Hierarchy
- negative regulation of innate immune response
- negative regulation of innate immune response
- negative regulation of innate immune response
- negative regulation of innate immune response
- negative regulation of innate immune response
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
negative regulation of immune system process [inference]
regulation of immune response [inference]
regulation of innate immune response [inference]
regulation of pattern recognition receptor signaling pathway [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of biosynthetic process [inference]
regulation of cellular biosynthetic process [inference]
negative regulation of metabolic process [inference]
negative regulation of biosynthetic process [inference]
negative regulation of macromolecule metabolic process [inference]
negative regulation of cellular metabolic process [inference]
regulation of cellular metabolic process [inference]
negative regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
negative regulation of phosphorus metabolic process [inference]
regulation of phosphate metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
negative regulation of macromolecule metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of signal transduction [inference]
negative regulation of signal transduction [inference]
regulation of pattern recognition receptor signaling pathway [inference]
negative regulation of signaling [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
negative regulation of immune system process [inference]
negative regulation of metabolic process [inference]
negative regulation of biosynthetic process [inference]
negative regulation of macromolecule metabolic process [inference]
negative regulation of cellular metabolic process [inference]
negative regulation of signaling [inference]
negative regulation of cellular process [inference]
negative regulation of cell communication [inference]
negative regulation of cellular metabolic process [inference]
negative regulation of response to stimulus [inference]
regulation of response to stimulus [inference]
regulation of response to biotic stimulus [inference]
regulation of innate immune response [inference]
regulation of pattern recognition receptor signaling pathway [inference]
regulation of signal transduction [inference]
negative regulation of signal transduction [inference]
regulation of pattern recognition receptor signaling pathway [inference]
regulation of response to external stimulus [inference]
regulation of innate immune response [inference]
regulation of pattern recognition receptor signaling pathway [inference]
negative regulation of response to stimulus [inference]
regulation of immune response [inference]
regulation of innate immune response [inference]
regulation of pattern recognition receptor signaling pathway [inference]
regulation of response to stress [inference]
regulation of defense response [inference]
regulation of innate immune response [inference]
regulation of pattern recognition receptor signaling pathway [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of signal transduction [inference]
negative regulation of signal transduction [inference]
regulation of pattern recognition receptor signaling pathway [inference]
negative regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
negative regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
negative regulation of phosphorus metabolic process [inference]
regulation of phosphate metabolic process [inference]
regulation of cell population proliferation [inference]
regulation of programmed cell death [inference]
negative regulation of cellular process [inference]
negative regulation of cell communication [inference]
negative regulation of cellular metabolic process [inference]
regulation of multicellular organismal process [inference]
regulation of molecular function [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protease binding | ||
| DNA binding | ||
| ubiquitin-protein transferase activity | ||
| cysteine-type deubiquitinase activity | ||
| cysteine-type deubiquitinase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- OTU domain-containing protein
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| K63-linked polyubiquitin modification-dependent protein binding |
| hydrolase activity |
| metal ion binding |
| zinc ion binding |
| InterPro |
|---|
| OTU domain |
| Zinc finger, A20-type |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080944 | familial Behcet-like autoinflammatory syndrome | |
| DOID:1612 | breast cancer | |
| DOID:5041 | esophageal cancer | |
| DOID:9256 | colorectal cancer |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 7128 | ZFIN:ZDB-GENE-100212-2 | ||
| 21929 | ZFIN:ZDB-GENE-100212-2 | MOUSE02056 | |
| 472136 | PANTR39176 | ||
| 484006 | CANLF00149 | ||
| 508105 | BOVIN35873 | ||
| 683206 | RATNO17769 | ||
| 704130 | MACMU33985 | ||
| 100025842 | MONDO14297 | ||
| 100073197 | HORSE02814 | ||
| 100075332 | ORNAN16380 |
