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Fibroblast growth factor receptor 1
Summary
- Gene Symbol
-
- Fgfr1
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- ATP-binding
- Cell membrane
- Cytoplasm
- Cytoplasmic vesicle
- Disulfide bond
- Glycoprotein
- Heparin-binding
- Immunoglobulin domain
- Nucleus
- Phosphoprotein
- Receptor
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Tyrosine-protein kinase
- Ubl conjugation
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of stem cell proliferation | ||
| positive regulation of parathyroid hormone secretion | ||
| positive regulation of endothelial cell chemotaxis | ||
| regulation of extrinsic apoptotic signaling pathway in absence of ligand |
GO Hierarchy
- insulin receptor signaling pathway
- brain-derived neurotrophic factor receptor signaling pathway
- collagen-activated tyrosine kinase receptor signaling pathway
- vascular endothelial growth factor signaling pathway
- Kit signaling pathway
- insulin-like growth factor receptor signaling pathway
- hepatocyte growth factor receptor signaling pathway
- ephrin receptor signaling pathway
- insulin receptor signaling pathway
- brain-derived neurotrophic factor receptor signaling pathway
- collagen-activated tyrosine kinase receptor signaling pathway
- vascular endothelial growth factor signaling pathway
- Kit signaling pathway
- insulin-like growth factor receptor signaling pathway
- hepatocyte growth factor receptor signaling pathway
- ephrin receptor signaling pathway
biological process
metabolic process [inference]
cellular process [inference]
signal transduction [inference]
cell surface receptor signaling pathway [inference]
enzyme-linked receptor protein signaling pathway [inference]
transmembrane receptor protein tyrosine kinase signaling pathway [inference]
developmental process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process
regulation of signaling [inference]
regulation of localization [inference]
regulation of growth [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of signaling [inference]
positive regulation of cellular process [inference]
positive regulation of response to stimulus [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
signal transduction [inference]
cell surface receptor signaling pathway [inference]
enzyme-linked receptor protein signaling pathway [inference]
transmembrane receptor protein tyrosine kinase signaling pathway [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process
regulation of cell population proliferation
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of cell cycle [inference]
regulation of cell motility [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| nucleus | ||
| cytosol | ||
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein tyrosine kinase activity | ||
| GPI-linked ephrin receptor activity | ||
| transmembrane-ephrin receptor activity | ||
| epidermal growth factor receptor activity | ||
| fibroblast growth factor receptor activity |
GO Hierarchy
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
molecular function
catalytic activity [inference]
transferase activity [inference]
transferase activity, transferring phosphorus-containing groups [inference]
kinase activity [inference]
protein kinase activity [inference]
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity [inference]
transmembrane receptor protein kinase activity [inference]
transmembrane receptor protein tyrosine kinase activity [inference]
phosphotransferase activity, alcohol group as acceptor [inference]
protein kinase activity [inference]
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity [inference]
transmembrane receptor protein kinase activity [inference]
transmembrane receptor protein tyrosine kinase activity [inference]
catalytic activity, acting on a protein [inference]
protein kinase activity [inference]
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity [inference]
transmembrane receptor protein kinase activity [inference]
transmembrane receptor protein tyrosine kinase activity [inference]
binding [inference]
molecular transducer activity [inference]
signaling receptor activity [inference]
transmembrane signaling receptor activity [inference]
transmembrane receptor protein kinase activity [inference]
transmembrane receptor protein tyrosine kinase activity [inference]
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- fibroblast growth factor receptor A
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| fibroblast growth factor receptor activity |
| nucleotide binding |
| transmembrane receptor protein tyrosine kinase activity |
Alliance of Genome Resources
- Expression
| Location | References |
|---|---|
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:6432 | pulmonary hypertension |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 116435512 | CORMO12932 | ||
| 116821412 | CHEAB08451 | ||
| 117021283 | RHIFE03936 | ||
| 118313772 | SCOMX32312 | ||
| 118887767 | BALMU31288 | ||
| 122217613 | PANLE26957 | ||
| 123780346 | URSAM23882 |
