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tyrosyl-tRNA synthetase 1

Summary

Gene Symbol

YARS1

Organism

Homo sapiens (human)

External Links

NCBI Gene

8565

PubChem

8565

Alliance of Genome Resources

HGNC:12840

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Aminoacyl-tRNA synthetase
Charcot-Marie-Tooth disease
Cytoplasm
Direct protein sequencing
Disease variant
Neurodegeneration
Nucleus
Phosphoprotein
Protein biosynthesis
Reference proteome
tRNA-binding

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0S2Z4R1	Tyrosyl-tRNA synthetase
P54577	Tyrosyl-tRNA synthetase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
tyrosyl-tRNA aminoacylation	IDA	25533949
response to starvation	IDA	25533949
apoptotic process	TAS	10102815

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

tyrosyl-tRNA aminoacylation

response to stimulus [inference]

response to stress [inference]

response to starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to starvation

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nuclear body	IDA
extracellular space	TAS	10102815
nucleus	IDA	22291016 25533949
cytosol	IDA TAS	22291016
cytoplasm	IDA	25533949

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	24965446 25533949 32814053
interleukin-8 receptor binding	TAS	10102815
tRNA binding	IEA
small molecule binding	IDA	25533949
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

ligase activity [inference]

ligase activity, forming carbon-oxygen bonds [inference]

aminoacyl-tRNA ligase activity [inference]

tyrosine-tRNA ligase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

catalytic activity, acting on a tRNA [inference]

aminoacyl-tRNA ligase activity [inference]

tyrosine-tRNA ligase activity

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

chemokine receptor binding [inference]

CXCR chemokine receptor binding [inference]

interleukin-8 receptor binding

cytokine receptor binding [inference]

chemokine receptor binding [inference]

CXCR chemokine receptor binding [inference]

interleukin-8 receptor binding

small molecule binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

tRNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Tyrosine tRNA ligase

Functional Category

J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
ATP binding
ligase activity
nucleotide binding
tRNA aminoacylation for protein translation
tyrosine-tRNA ligase activity
tyrosyl-tRNA aminoacylation

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0110199	Charcot-Marie-Tooth disease dominant intermediate C	Alliance of Genome Resources
DOID:070355	multisystem proteinopathy	Alliance of Genome Resources
DOID:10595	Charcot-Marie-Tooth disease	Alliance of Genome Resources
DOID:162	cancer	Alliance of Genome Resources
DOID:870	neuropathy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 87 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	39829		FB:FBgn0027080
Mus musculus	107271		MGI:2147627	MOUSE39531
Caenorhabditis elegans	173311		WB:WBGene00013677
Bos taurus	281581			BOVIN24947
Rattus norvegicus	313047		RGD:1307616	RATNO34539
Danio rerio	368235		ZFIN:ZDB-GENE-030425-2	DANRE15774
Xenopus laevis	380438		Xenbase:XB-GENE-491612
Xenopus tropicalis	448444		Xenbase:XB-GENE-491608
Pan troglodytes	469266	9598_0:00074b		PANTR20554
Canis lupus familiaris	478148			CANLF06889

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Last updated: December 9, 2024